Details of the Drug Combinations

General Information of This Drug (ID: DM51FY6)

Drug Name
Tacrine   DM51FY6
Synonyms
Cognex; Romotal; Tacrina; Tacrinal; Tacrinum; Tenakrin; Tetrahydroaminacrine; Tetrahydroaminoacridine; Tetrahydroaminocrin; Tetrahydroaminocrine; Tha; Tacrine hydrochloride; BBL001044; CS 12602; Cognex (TN); Tacrina [INN-Spanish]; Tacrinal (TN); Tacrine (INN); Tacrine [INN:BAN]; Tacrinum [INN-Latin]; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8); 1,2,3,4-Tetrahydro-9-acridineamine; 1,2,3,4-Tetrahydro-acridin-9-ylamine; 1,2,3,4-Tetrahydroaminoacridine; 1,2,3,4-tetrahydroacridin-9-amine; 5-Amino-6,7,8,9-tetrahydroacridine (European); 9-AMINOTETRAHYDROACRIDINE; 9-Acridinamine, 1,2,3,4-tetrahydro-(9CI); 9-Amino-1,2,3,4-Tetrahydroacridine Hydrate Hydrochloride Hydrate; 9-amino-1,2,3,4-tetrahydroacridine
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Approved [1]
Therapeutic Class
Parasympathomimetics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

54 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Tacrine DCM3LUU Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aciclovir + Tacrine DCJ7VQD Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Tacrine DC2WA76 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Tacrine DCLSSXO Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Tacrine DCO3O5D Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Tacrine DCW8W14 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Tacrine DCWQNBI Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + Tacrine DC5IYHA Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dantrolene + Tacrine DCWF005 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Docetaxel + Tacrine DCAZNFN Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Enoxacin + Tacrine DCV73W3 Enoxacin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + Tacrine DC447TZ Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fosfomycin + Tacrine DC08NRC Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Tacrine DC0B1RF Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Tacrine DC82WT6 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Tacrine DC20WTU JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + Tacrine DCRF4CA Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mebutamate + Tacrine DCEZPCN Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mesalazine + Tacrine DC0RJ52 Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methoxsalen + Tacrine DCC9Y18 Methoxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + Tacrine DCE3A1F Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylergonovine + Tacrine DC55ZGR Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Tacrine DCBB548 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Naltrexone + Tacrine DCDI1WX Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Niclosamide + Tacrine DCP7I98 Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Tacrine DCGXLFS Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sertraline + Tacrine DCK4LB9 Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Aprepitant DCJF0RF Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Gefitinib DCZWSB9 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Diethylcarbamazine DC2HC8Q Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Kanamycin DCWQU6X Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Furazolidone DCI0UAM Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Methotrexate DCJ97BC Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Vinblastine DCD1R7P Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Triapine DCB3B30 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Acitretin DCEGV2B Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Everolimus DCPD7PO Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Itraconazole DCWD30E Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Emetine DCJMC4P Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Nizatidine DC10V1C Nizatidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Clopidogrel DCBV4FS Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Diazoxide DCB1EJX Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Idarubicin DCMUMWF Idarubicin Glioblastoma? (Cell Line: T98G) [2]
Tacrine + Trimethobenzamide DC70J62 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Leflunomide DCNARUQ Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Hyodeoxycholic acid DCRGW5Q Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Mycophenolic acid DCNAY0L Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Mefloquine DC7CKJI Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Pizotyline DCL3RIL Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Vorinostat DCSO9S4 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + Tacrine DC23Y8A Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + Tacrine DCZNEK3 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolazoline + Tacrine DC5V6HJ Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tropisetron + Tacrine DCKZRDS Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 54 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6687).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.