Details of the Drug Combinations

General Information of This Drug (ID: DMSIVND)

Drug Name
Hydroxychloroquine   DMSIVND
Synonyms
Hidroxicloroquina; Hidroxicloroquina [INN-Spanish]; Hydroxychlorochin; Gen-Hydroxychloroquine 200mg Tablets; HCQ; Hydroxychloroguine; Hydroxychloroquine (INN);Hydroxychloroquine [INN:BAN]; Hydroxychloroquine Sulfate (1:1) Salt; Hydroxychloroquinum; Hydroxychloroquinum [INN-Latin]; Idrossiclorochina; Idrossiclorochina [DCIT]; Oxichlorochinum; Oxichloroquine; Oxychlorochin; Oxychloroquine; Plaquenil (TN); Polirreumin; Polirreumin (TN); Quensyl; WIN 1258
Indication
Disease Entry ICD 11 Status REF
Chronic renal failure GB61.Z Approved [1]
Malaria 1F40-1F45 Approved [2]
Plasmodium falciparum malaria 1F40 Approved [1]
Plasmodium malariae malaria N.A. Approved [1]
Plasmodium ovale malaria N.A. Approved [1]
Systemic lupus erythematosus 4A40.0 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Colon cancer 2B90.Z Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antimalarials
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

51 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Anamorelin + Hydroxychloroquine DC47ZO6 Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Arfolitixorin + Hydroxychloroquine DCACQOC Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Brincidofovir + Hydroxychloroquine DCG7E9X Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cerivastatin + Hydroxychloroquine DC3JPNJ Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Chlorzoxazone + Hydroxychloroquine DCBYB45 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Citalopram + Hydroxychloroquine DCP9CR6 Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cytarabine + Hydroxychloroquine DCR07DB Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Diethylcarbamazine + Hydroxychloroquine DC67JV0 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Docetaxel + Hydroxychloroquine DCKJSSN Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Doxorubicin + Hydroxychloroquine DC9SFS4 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Epinephrine + Hydroxychloroquine DC5EO1O Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Fomepizole + Hydroxychloroquine DCD2XUN Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Fosfomycin + Hydroxychloroquine DCLDLW2 Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Aprepitant DCJ81NL Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Dantrolene DC1IQIG Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Vinblastine DCMQYQH Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Tolazoline DCGTMG9 Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + BIO-300 DC6AJ5M BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Tiagabine DCXTEHU Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Diazoxide DCDWWXX Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Allopurinol DC8B542 Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Imatinib DCCTFOL Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Bortezomib DCYMPC7 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Artemisinin DC41WKW Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Trimethobenzamide DCMHNH0 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Maprotiline DCIH97K Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Acetohexamide DCF44GH Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Hyodeoxycholic acid DCWABGP Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Hydroxychloroquine + Cilostazol DCSTI1U Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Ibutilide + Hydroxychloroquine DCKWPW8 Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
IT-141 + Hydroxychloroquine DCFBY63 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Kanamycin + Hydroxychloroquine DCABGRP Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Levamisole + Hydroxychloroquine DCS6DUO Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Metformin + Hydroxychloroquine DCX7199 Metformin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Methotrexate + Hydroxychloroquine DCLQ05L Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Methylene blue + Hydroxychloroquine DCXRDE4 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Metyrosine + Hydroxychloroquine DCFIP0S Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Mycophenolic acid + Hydroxychloroquine DCDLVQY Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pinacidil + Hydroxychloroquine DCFI6AQ Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pramipexole + Hydroxychloroquine DCY7IDG Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Pyrazinamide + Hydroxychloroquine DCNCLE9 Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Repaglinide + Hydroxychloroquine DCYFGRK Repaglinide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Terameprocol + Hydroxychloroquine DCCPHGL Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Terazosin + Hydroxychloroquine DCEQSV0 Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Teriflunomide + Hydroxychloroquine DCONJH0 Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Tindamax + Hydroxychloroquine DCW1FW9 Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triapine + Hydroxychloroquine DC5292I Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Trihexyphenidyl + Hydroxychloroquine DCBCPTA Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trimethobenzamide + Hydroxychloroquine DCNXDR6 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Vorinostat + Hydroxychloroquine DC0EVEW Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Zaleplon + Hydroxychloroquine DCSEZ6C Zaleplon Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
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⏷ Show the Full List of 51 DrugCom(s)
46 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Arry-162 + Hydroxychloroquine DCZ4PQJ Arry-162 Metastatic Pancreatic Adenocarcinoma [6]
Bortezomib + Hydroxychloroquine DC41Z69 Bortezomib Multiple Myeloma and Plasma Cell Neoplasm [7]
Bromhexine + Hydroxychloroquine DCCDYTY Bromhexine Hydroxychloroquine [8]
BVD-523 + Hydroxychloroquine DCSQZU4 BVD-523 Gastrointestinal Neoplasms [9]
Capecitabine + Hydroxychloroquine DC7K2S6 Capecitabine Pancreatic Cancer [10]
Docetaxel + Hydroxychloroquine DCPKO3J Docetaxel Prostate Cancer [11]
Erlotinib + Hydroxychloroquine DC8E5ST Erlotinib Non-small Cell Lung Cancer [12]
Everolimus + Hydroxychloroquine DC8H66W Everolimus Metastatic Clear Cell Renal Cell Carcinoma [13]
Favipiravir + Hydroxychloroquine DC96P2Z Favipiravir COVID-19 [14]
Gemcitabine + Hydroxychloroquine DCPQ42P Gemcitabine Pancreatic Cancer [15]
Itraconazole + Hydroxychloroquine DC273GQ Itraconazole Platinum-resistant Epithelial Ovarian Cancer [16]
Ixabepilone + Hydroxychloroquine DCZWQCY Ixabepilone Breast Cancer [17]
LY2835219 + Hydroxychloroquine DC2D0P2 LY2835219 Solid Tumor [18]
Mesalazine + Hydroxychloroquine DCYG0ZM Mesalazine Ulcerative Colitis (Disorder) [19]
Montelukast + Hydroxychloroquine DCTRRRI Montelukast Covid19 [20]
PF-05212384 + Hydroxychloroquine DCNISK7 PF-05212384 Breast Cancer [21]
Prednisolone + Hydroxychloroquine DC2LI4D Prednisolone Lupus Nephritis [22]
Prednisolone + Hydroxychloroquine DCEGATO Prednisolone Lupus Nephritis [22]
Temozolomide + Hydroxychloroquine DCU4302 Temozolomide Brain and Central Nervous System Tumors [23]
Trametinib + Hydroxychloroquine DCYLUD6 Trametinib Metastatic Pancreatic Carcinoma [24]
Vorinostat + Hydroxychloroquine DCS2EYR Vorinostat Malignant Solid Tumour [25]
Azithromycin + Hydroxychloroquine DC6CLQX Azithromycin Virus Diseases [26]
Baricitinib + Hydroxychloroquine DCNWGOT Baricitinib Symptomatic COVID-19 Infection Laboratory-Confirmed [27]
Benazepril + Hydroxychloroquine DCFPEZJ Benazepril Alport Syndrome, X-Linked [28]
BVD-523 + Hydroxychloroquine DCW0FZX BVD-523 Tumor, Solid [29]
Everolimus + Hydroxychloroquine DC22PNW Everolimus Breast Cancer Stage IIB [30]
Ivermectin + Hydroxychloroquine DC4A3GX Ivermectin Covid19 [31]
LY2835219 + Hydroxychloroquine DC7L5M5 LY2835219 Breast Cancer [32]
Nitazoxanide + Hydroxychloroquine DC2KPX7 Nitazoxanide Coronavirus Disease 2019 (COVID-19) [33]
Prednisolone + Hydroxychloroquine DCP777J Prednisolone Inflammatory Cardiomyopathy [34]
Remdesivir + Hydroxychloroquine DC0FMOW Remdesivir SARS-CoV Infection [35]
Tofacitinib + Hydroxychloroquine DC8XX7S Tofacitinib Pneumonitis, Interstitial [36]
Azithromycin + Hydroxychloroquine DC8Y9J6 Azithromycin COVID19 [37]
Azithromycin + Hydroxychloroquine DC5HNLI Azithromycin Coronavirus Disease 2019 (COVID-19) [38]
Azithromycin + Hydroxychloroquine DCHHDRF Azithromycin Coronavirus Disease 2019 (COVID-19) [39]
Bromhexine + Hydroxychloroquine DCWHDEZ Bromhexine Coronavirus Disease 2019 (COVID-19) [40]
Camostat mesylate + Hydroxychloroquine DCINTA5 Camostat mesylate Coronavirus Disease 2019 (COVID-19) [41]
Chloroquine + Hydroxychloroquine DC5QFXT Chloroquine COVID [42]
Ivermectin + Hydroxychloroquine DC37HGN Ivermectin Coronavirus Disease 2019 (COVID-19) [43]
Methylprednisolone + Hydroxychloroquine DC3P733 Methylprednisolone Thrombocytopenia [44]
Oseltamivir + Hydroxychloroquine DC4NSH5 Oseltamivir COVID 19 [45]
Oseltamivir + Hydroxychloroquine DCFWJ0U Oseltamivir Coronavirus Disease 2019 (COVID-19) [46]
Camostat + Hydroxychloroquine DC7J8ME Camostat COVID [47]
Favipiravir + Hydroxychloroquine DCOG67U Favipiravir COVID-19 [48]
Nitazoxanide + Hydroxychloroquine DCESWDP Nitazoxanide Coronavirus Infection [49]
Valsartan + Hydroxychloroquine DC5NZ4M Valsartan Primary IgA Nephropathy [50]
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⏷ Show the Full List of 46 DrugCom(s)

References

1 Hydroxychloroquine FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7198).
3 ClinicalTrials.gov (NCT04341727) Hydroxychloroquine,Hydroxychloroquine,Azithromycin in the Treatment of SARS CoV-2 Infection (WU352). U.S. National Institutes of Health.
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
6 ClinicalTrials.gov (NCT04132505) Binimetinib and Hydroxychloroquine in Treating Patients With KRAS Mutant Metastatic Pancreatic Cancer
7 ClinicalTrials.gov (NCT00568880) Hydroxychloroquine and Bortezomib in Treating Patients With Relapsed or Refractory Multiple Myeloma
8 ClinicalTrials.gov (NCT04340349) Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals
9 ClinicalTrials.gov (NCT04145297) Ulixertinib (BVD-523) and Hydroxychloroquine in Patients w Advanced MAPK-Mutated Gastrointestinal Adenocarcinomas
10 ClinicalTrials.gov (NCT01494155) Short Course Radiation Therapy With Proton or Photon Beam Capecitabine and Hydroxychloroquine for Resectable Pancreatic Cancer
11 ClinicalTrials.gov (NCT00786682) Docetaxel and Hydroxychloroquine in Treating Patients With Metastatic Prostate Cancer
12 ClinicalTrials.gov (NCT00977470) Erlotinib With or Without Hydroxychloroquine in Chemo-Naive Advanced NSCLC and (EGFR) Mutations
13 ClinicalTrials.gov (NCT01510119) Autophagy Inhibition to Augment Mammilian Target of Rapamycin (mTOR) Inhibition: A Phase I/II Trial of RAD001 and Hydroxychloroquine (HCQ) in Patients With Previously Treated Renal Cell Carcinoma
14 ClinicalTrials.gov (NCT04376814) Favipiravir Plus Hydroxychloroquine and Lopinavir/Ritonavir Plus Hydroxychloroquine in COVID-19
15 ClinicalTrials.gov (NCT01128296) Study of Pre-surgery Gemcitabine + Hydroxychloroquine (GcHc) in Stage IIb or III Adenocarcinoma of the Pancreas
16 ClinicalTrials.gov (NCT03081702) A Study of the Safety, Tolerability and Effectiveness of Hydroxychloroquine and Itraconazole in Platinum-resistant Epithelial Ovarian Cancer
17 ClinicalTrials.gov (NCT00765765) Ixabepilone and Hydroxychloroquine in Treating Patients With Metastatic Breast Cancer
18 ClinicalTrials.gov (NCT04316169) Hydroxychloroquine, Abemaciclib and Endocrine Therapy in Hormone Receptor Positive (HR+)/Her 2 Negative Breast Cancer
19 ClinicalTrials.gov (NCT05119140) Administration of Hydroxychloroquine (Plaquenil) to African Americans and Hispanics for the Treatment of Mild to Severe Ulcerative Colitis
20 ClinicalTrials.gov (NCT04714515) Montelukast - a Treatment Choice for COVID-19
21 ClinicalTrials.gov (NCT03400254) Gedatolisib, Hydroxychloroquine or the Combination for Prevention of Recurrent Breast Cancer ("GLACIER")
22 ClinicalTrials.gov (NCT03791827) Multicenter Registry of Pediatric Lupus Nephritis in China
23 ClinicalTrials.gov (NCT00486603) Hydroxychloroquine, Radiation, and Temozolomide Treating Patients With Newly Diagnosed Glioblastoma Multiforme
24 ClinicalTrials.gov (NCT03825289) Trametinib and Hydroxychloroquine in Treating Patients With Pancreatic Cancer
25 ClinicalTrials.gov (NCT01023737) Hydroxychloroquine + Vorinostat in Advanced Solid Tumors
26 ClinicalTrials.gov (NCT04322396) Proactive Protection With Azithromycin and hydroxyChloroquine in Hospitalized Patients With COVID-19
27 ClinicalTrials.gov (NCT04373044) Baricitinib, Placebo and Antiviral Therapy for the Treatment of Patients With Moderate and Severe COVID-19
28 ClinicalTrials.gov (NCT04937907) Study of Hydroxychloroquine in Patients With X-linked Alport Syndrome in China (CHXLAS)
29 ClinicalTrials.gov (NCT05221320) Trial of Ulixertinib in Combination With Hydroxychloroquine in Patients With Advanced Gastrointestinal (GI) Malignancies
30 ClinicalTrials.gov (NCT03032406) CLEVER Pilot Trial: A Phase II Pilot Trial of HydroxyChLoroquine, EVErolimus or the Combination for Prevention of Recurrent Breast Cancer
31 ClinicalTrials.gov (NCT04712279) The (HD)IVACOV Trial (The High-Dose IVermectin Against COVID-19 Trial)
32 ClinicalTrials.gov (NCT04523857) ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer
33 ClinicalTrials.gov (NCT04361318) Hydroxychloroquine and Nitazoxanide Combination Therapy for COVID-19. U.S. National Institutes of Health.
34 ClinicalTrials.gov (NCT05961202) The Effects of Hydroxychloroquine in Patients With Inflammatory Cardiomyopathy
35 ClinicalTrials.gov (NCT04321616) The Efficacy of Different Anti-viral Drugs in COVID 19 Infected Patients
36 ClinicalTrials.gov (NCT04390061) TOFAcitinib Plus Hydroxycloroquine vs Hydroxycloroquine in Patients With COVID-19 Interstitial Pneumonia
37 ClinicalTrials.gov (NCT04328272) Effectiveness of Hydroxychloroquine in Covid-19 Patients
38 ClinicalTrials.gov (NCT04321278) Safety and Efficacy of Hydroxychloroquine Associated With Azithromycin in SARS-CoV2 Virus (Coalition Covid-19 Brasil II). U.S. National Institutes of Health.
39 ClinicalTrials.gov (NCT04371406) Efficacy of Azithromycin-associated Hydroxychloroquine Therapy Given in General Practice in Early-stage Disease in COVID-19 Patients. U.S. National Institutes of Health.
40 Use of Bromhexine and Hydroxychloroquine for Treatment of COVID-19 Pneumonia
41 ClinicalTrials.gov (NCT04355052) Open Label Study to Compare Efficacy, Safety and Tolerability of Hydroxychloroquine Combined With Azithromycin Compared to Hydroxychloroquine Combined With Camostat Mesylate and to "no Treatment" in SARS CoV 2 Virus. U.S. National Institutes of Health.
42 ClinicalTrials.gov (NCT04420247) Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19
43 ClinicalTrials.gov (NCT04374019) Novel Agents for Treatment of High-risk COVID-19 Positive Patients. U.S. National Institutes of Health.
44 ClinicalTrials.gov (NCT02444728) Cyclophosphamide and Hydroxychloroquine for Thrombocytopenia in SLE
45 ClinicalTrials.gov (NCT04338698) Hydroxychloroquine, Oseltamivir and Azithromycin for the Treatment of COVID-19 Infection: An RCT
46 ClinicalTrials.gov (NCT04303299) Various Combination of Protease Inhibitors, Oseltamivir, Favipiravir, and Hydroxychloroquine for Treatment of COVID-19 : A Randomized Control Trial
47 ClinicalTrials.gov (NCT04338906) Combination Therapy With Camostat Mesilate + Hydroxychloroquine for COVID-19
48 ClinicalTrials.gov (NCT04359615) Favipiravir in Hospitalized COVID-19 Patients
49 ClinicalTrials.gov (NCT04341493) Hydroxychloroquine vs Nitazoxanide in Patients With COVID-19
50 ClinicalTrials.gov (NCT02765594) Hydroxychloroquine Sulfate Alleviates Persistent Proteinuria in IgA Nephropathy