Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1CG0J)

• Drug Name: GGTI-298 Drug Info
• Synonyms: GGTI298; GGTI-298; Ggti 298; 180977-44-0; CHEMBL282748; N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA; (S)-methyl 2-(4-((R)-2-amino-3-mercaptopropylamino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate; SCHEMBL4283635; CHEBI:124997; EX-A2390; ZINC1488051; BCP24854; BDBM50076138; AKOS032945065; CS-6098; NCGC00165800-01; HY-100876; BRD-K19669037-019-01-3; 2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acid (S)-methyl ester
• Cross-matching ID:
  PubChem CID: 9811606
  ChEBI ID: CHEMBL282748
  CAS Number: CAS 180977-44-0
  TTD Drug ID: DM1CG0J

Molecule-Related Drug Atlas

Drug(s) Targeting Geranylgeranyl transferase I (GGTase-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-778123	DMWSC5L	Lymphoma	2A80-2A86	Phase 1	[4]
L-745631	DM4UP7R	Solid tumour/cancer	2A00-2F9Z	Terminated	[5]
PD-83176	DMSIMKZ	Discovery agent	N.A.	Investigative	[6]
A-313326	DML4P6O	Discovery agent	N.A.	Investigative	[7]
J-109,390	DM9SFGB	Discovery agent	N.A.	Investigative	[8]
L-269,289	DMV6018	Discovery agent	N.A.	Investigative	[8]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[9]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[10]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[11]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[12]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[13]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[14]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[16]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]

Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[16]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[31]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[34]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranylgeranyl transferase I (GGTase-I)	TTX20QP	PGTB1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[2]
Krueppel-like factor 2 (KLF2)	OTIP1UFX	KLF2_HUMAN	Gene/Protein Processing	[2]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Gene/Protein Processing	[3]

References

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