Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1S4AG)

Drug Name
Lumiracoxib Drug Info
Synonyms
Joicela; Prexige; Novartis brand of lumiracoxib; COX 189; COX189; COX-189; Lumiracoxib [USAN:INN]; Prexige (Novartis); Prexige (TN); Lumiracoxib (USAN/INN); 2-((2-Chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid; 2-((2-Chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid; 2-(2-((2-chloro-6-fluoro-phenyl)amino)-5-methyl-phenyl)acetic acid; 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid
Indication
Disease Entry ICD 11 Status REF
Chronic renal failure GB61.Z Approved [1]
Knee osteoarthritis FA01 Approved [2]
Osteoarthritis FA00-FA05 Approved [3]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
151166
ChEBI ID
CHEBI:73044
CAS Number
CAS 220991-20-8
TTD Drug ID
DM1S4AG
VARIDT Drug ID
DR01172
INTEDE Drug ID
DR0993

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [9]
Naproxen DMZ5RGV Bursitis Approved [10]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [11]
Indomethacin DMSC4A7 Bursitis Approved [12]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [13]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [14]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [15]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [16]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [17]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [12]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [19]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [20]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [21]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [22]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [24]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [26]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [27]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [33]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [34]
Estrone DM5T6US Acne vulgaris ED80 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [37]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [38]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [39]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [40]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [42]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [43]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [45]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [6]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [47]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [6]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [6]
Haloperidol DM96SE0 Delirium Approved [6]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [49]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [50]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [53]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [7]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [7]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [66]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [69]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [70]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [71]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [72]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [7]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [7]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [7]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [7]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [7]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [7]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [74]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [75]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [7]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [76]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [7]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [78]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [81]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [83]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [84]
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Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [7]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [7]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [7]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [7]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [86]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [7]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
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Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [7]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [7]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [7]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [91]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [7]
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Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Fluoxetine DM3PD2C Bipolar depression Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
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Drug(s) Affected By HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [8]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [97]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [98]
Testosterone enanthate DMB6871 N. A. N. A. Approved [99]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [100]
Arsenic DMTL2Y1 N. A. N. A. Approved [101]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [102]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [103]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [104]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [104]
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Drug(s) Affected By HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [105]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [105]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [107]
Cefepime DMHVWIK Bacterial infection 1A00-1C4Z Approved [105]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [108]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [109]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [110]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [111]
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Drug(s) Affected By HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [112]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [108]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [109]
Arsenic DMTL2Y1 N. A. N. A. Approved [101]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [113]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [114]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [115]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [116]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [117]
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Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [105]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [105]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [103]
Allopurinol DMLPAOB Gout FA25 Approved [119]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [120]
Selenium DM25CGV N. A. N. A. Approved [121]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [123]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [5]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [5]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [5]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [7]
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Gene/Protein Processing [7]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Gene/Protein Processing [7]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [7]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) OTC6GISG DQA1_HUMAN Drug Response [8]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Drug Response [8]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5) OTUX5TWM DRB5_HUMAN Drug Response [8]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Drug Response [8]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [7]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Gene/Protein Processing [7]

References

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