Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM31ZQM)

Drug Name
Tegafur Drug Info
Synonyms Tegafur (Fluoropyrimidine)
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Approved [1]
Cross-matching ID
PubChem CID
5386
ChEBI ID
CHEBI:32188
CAS Number
CAS 17902-23-7
TTD Drug ID
DM31ZQM
INTEDE Drug ID
DR1539

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [2]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [9]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [10]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [11]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [12]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [13]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [14]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [15]
Verapamil DMA7PEW Angina pectoris BA40 Approved [16]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [2]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [4]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Metronidazole DMTIVEN Abscess Approved [21]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [22]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Methoxsalen DME8FZ9 Cutaneous T-cell lymphoma 2B01 Approved [45]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [52]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [53]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [54]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [28]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [33]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [15]
Verapamil DMA7PEW Angina pectoris BA40 Approved [4]
Estrone DM5T6US Acne vulgaris ED80 Approved [37]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [38]
Ethanol DMDRQZU Chronic pain MG30 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [2]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [40]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [4]
Verapamil DMA7PEW Angina pectoris BA40 Approved [41]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [42]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [43]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [40]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [44]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dihydropyrimidine dehydrogenase (DPYD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [55]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [56]
Flucytosine DM13VTW Cryptococcal meningitis Approved [57]
Selenium DM25CGV N. A. N. A. Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytidine deaminase (CDA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [65]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [78]
Paclitaxel DMLB81S Breast carcinoma Approved [79]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [80]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [83]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [2]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [3]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [4]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [2]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Drug Response [5]
Cytidine deaminase (CDA) OT3HXP6N CDD_HUMAN Drug Response [6]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Drug Response [7]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Drug Response [6]
Thymidylate synthase OTXTG0C7 TYSY_HUMAN Drug Response [8]

References

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