Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3JDRP)

• Drug Name: Cladribine Drug Info
• Synonyms: Chlorodeoxyadenosine; Cladarabine; Cladaribine; Cladribina; Cladribinum; CldAdo; Leustat; Leustatin; Litak; Movectro;Mylinax; CL9; RWJ 26251; Leustatin (TN); RWJ-26251; Cladribine [USAN:INN:BAN]; RWJ-26251-000; Cladribine (JAN/USAN/INN); Leustatin, 2-chlorodeoxyadenosine, Cladribine; Adenosine, 2-chloro-2'-deoxy; (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol; 2 Chlorodeoxyadenosine; 2'-Deoxy-2-chloroadenosine; 2-CdA; 2-Chloro-2'-deoxy-beta-adenosine; 2-Chloro-2'-deoxyadenosine; 2-Chloro-6-amino-9-(2-deoxy-beta-D-erythropentofuranosyl)purine; 2-Chlorodeoxyadenosine; 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine; 2-chloro-deoxyadenosine

Indication

Disease Entry	ICD 11	Status	REF
Hairy cell leukaemia	2A82.2	Approved	[1]
Multiple sclerosis	8A40	Phase 3	[2]
Relapsing-remitting multiple sclerosis	8A40.0	Phase 3	[3]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 20279
  ChEBI ID: CHEMBL1619
  CAS Number: CAS 4291-63-8
  TTD Drug ID: DM3JDRP
  VARIDT Drug ID: DR00087
  INTEDE Drug ID: DR1918
  ACDINA Drug ID: D00951

Molecule-Related Drug Atlas

Drug(s) Targeting Adenosine deaminase (ADA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Elapegademase	DMS7OU8	Adenosine deaminase defciency	4A01.1	Approved	[13]
Fludarabine	DMVRLT7	Acute myelogenous leukaemia	2A41	Approved	[14]
Pentostatin	DM0HXDS	Acute graft versus host disease	4B24.0	Approved	[14]
GSK2696273	DMP5O1U	Chronic pain	MG30	Preregistration	[15]
OTL-101	DMLMS6J	Severe combined immunodeficiency	4A01.10	Phase 3	[16]
Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy	DMIREUZ	Immunodeficiency	4A00-4A85	Phase 1/2	[15]
EHNA	DM014WS	Discovery agent	N.A.	Investigative	[17]
3-(6-Amino-purin-9-yl)-6-phenyl-hexan-2-ol	DMZT8QX	Discovery agent	N.A.	Investigative	[18]
3-(6-Amino-purin-9-yl)-8-phenyl-octan-2-ol	DMAIS1D	Discovery agent	N.A.	Investigative	[18]
1-Deaza-Adenosine	DMG0VN6	Discovery agent	N.A.	Investigative	[19]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[22]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[25]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[32]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[6]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[33]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[34]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[35]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[36]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[37]

Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[39]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[40]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[6]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[42]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[43]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[45]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[6]

Drug(s) Transported By Equilibrative nucleoside transporter 3 (SLC29A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
tubercidin	DMHICK8	Discovery agent	N.A.	Investigative	[5]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[5]

Drug(s) Metabolized By Deoxycytidine kinase (DCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[46]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[50]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[51]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[52]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[51]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[56]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[59]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[60]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[61]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[64]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[62]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[72]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[73]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[74]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[77]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[80]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[81]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[52]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[82]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[72]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[97]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[98]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[100]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[101]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine deaminase (ADA)	TTLP57V	ADA_HUMAN	Inhibitor	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Equilibrative nucleoside transporter 3 (SLC29A3)	DTZAWTH	S29A3_HUMAN	Substrate	[5]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[6]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[6]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[7]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Deoxycytidine kinase (DCK) Main DME	DE9FGNK	DCK_HUMAN	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[9]
Histone-lysine N-methyltransferase 2A (KMT2A)	OT9GLJI6	KMT2A_HUMAN	Drug Response	[10]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[11]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Protein Interaction/Cellular Processes	[12]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Gene/Protein Processing	[9]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[12]

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