Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3L52Q)

Drug Name
Chlorcyclizine Drug Info
Synonyms
1-(4-Chlorobenzhydryl)-4-methylpiperazine; Alergicide; Chlorcycline; Chlorcyclizine [INN:BAN]; Chlorcyclizinum; Chlorcyclizinum [INN-Latin]; Chlorocycline; Chlorocyclizine; Clorciclizina; Clorciclizina [DCIT]; Clorciclizinio [INN-Spanish]; Compound 47-282; Di-Paralene; Di-paralen; Diparalene; HSDB 3217; Histachlorazene; Histantin; Histantine; N-Methyl-N'-(4-chlorobenzhydryl)piperazine; NSC 25246; Perazyl; Piparalene; Trihistan; chlorcyclizine
Indication
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Approved [1]
Common cold CA00 Approved [2]
Cough MD12 Approved [3]
Seasonal allergic rhinitis CA08.01 Approved [2]
Vasomotor/allergic rhinitis CA08 Approved [4]
Therapeutic Class
Antihistamines
Cross-matching ID
PubChem CID
2710
ChEBI ID
CHEMBL22150
CAS Number
CAS 82-93-9
TTD Drug ID
DM3L52Q
VARIDT Drug ID
DR01215

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [8]
Folic Acid DMEMBJC Colorectal carcinoma Approved [9]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [10]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [11]
Verapamil DMA7PEW Angina pectoris BA40 Approved [12]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [13]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [14]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [15]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [16]
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Drug(s) Affected By Nuclear protein 1 (NUPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [6]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [18]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [19]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [18]
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Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [19]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [6]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [23]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [24]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [6]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [25]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [6]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [19]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [28]
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Drug(s) Affected By Inhibin beta E chain (INHBE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [6]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [19]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [18]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [6]
Panobinostat DM58WKG Chronic graft versus host disease Approved [30]
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Drug(s) Affected By Acid ceramidase (ASAH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [6]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [31]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [18]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [18]
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Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [34]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [6]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [37]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [18]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
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Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [6]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [19]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [18]
Fluoxetine DM3PD2C Bipolar depression Approved [18]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [6]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [39]
Testosterone DM7HUNW Hot flushes GA30 Approved [40]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [40]
Haloperidol DM96SE0 Delirium Approved [18]
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Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [6]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [18]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [6]
Haloperidol DM96SE0 Delirium Approved [18]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Clozapine DMFC71L Schizophrenia 6A20 Approved [6]
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Drug(s) Affected By Protein DEPP1 (DEPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [6]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [18]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [43]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [18]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [18]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Gene/Protein Processing [6]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Gene/Protein Processing [6]
Fibronectin type III domain-containing protein 4 (FNDC4) OTOQK0WK FNDC4_HUMAN Gene/Protein Processing [6]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Gene/Protein Processing [6]
Lysophospholipase D GDPD3 (GDPD3) OTOHM9QM GDPD3_HUMAN Gene/Protein Processing [6]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Gene/Protein Processing [6]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Gene/Protein Processing [6]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Gene/Protein Processing [6]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Gene/Protein Processing [6]
WD repeat domain phosphoinositide-interacting protein 1 OTV2NPHG WIPI1_HUMAN Gene/Protein Processing [6]

References

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4 Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1. Cell Chem Biol. 2020 Jul 16;27(7):780-792.e5.
5 Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. J Pharm Sci. 2005 Mar;94(3):613-24.
6 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
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11 Multidrug resistance-associated protein-1 functional activity in Calu-3 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1199-205.
12 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
13 ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8.
14 Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug Metab Dispos. 2008 Dec;36(12):2571-81.
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16 Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83.
17 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
18 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
19 In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
20 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
21 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
22 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
23 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
24 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
25 Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors. Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):701-6. doi: 10.1042/bj2900701.
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27 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
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31 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
32 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
33 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
34 Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
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37 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
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41 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
42 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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44 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.