Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM458UM)

Drug Name
Captopril Drug Info
Synonyms
Acediur; Aceplus; Acepress; Acepril; Alopresin; Apopril; Asisten; Capoten; Captolane; Captoprilum; Captopryl; Captoril; Captril; Cesplon; Dilabar; Garranil; Hipertil; Hypertil; Isopresol; Lopirin; Lopril; MCO; Tenosbon; Tensiomin; Tensobon; Tensoprel; Lopirin [Switzerland]; C 4042; SA 333; SQ 14225; X8Z; Apopril (TN); Capoten (TN); Captoprilum [INN-Latin]; Garranil (discontinued); L-Captopril; SQ 14,225; SQ-14225; SQ-14534; SQ-14,225; SQ-14,534; Captopril (JP15/USP/INN); Captopril [USAN:INN:BAN:JAN]; D-3-Mercapto-2-methylpropionylproline; D-2-Methyl-3-mercaptopropanoyl-L-proline; D-3-Mercapto-2-methylpropanoyl-L-proline; [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline; N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline;(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline; (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid; (S)-1-(3-Mercapto-2-methyl-1-oxo-propyl)-L-proline; (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline; 1-((2S)-3-Mercapto-2-methylpropionyl)-L-proline; 1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline; 1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S,S); 1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline; 3-Mercapto-2-methylpropionyl-proline
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Diabetic kidney disease GB61.Z Approved [1]
Hypertension BA00-BA04 Approved [2]
Malignant essential hypertension BA00 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
44093
ChEBI ID
CHEMBL1560
CAS Number
CAS 62571-86-2
TTD Drug ID
DM458UM
VARIDT Drug ID
DR00628
INTEDE Drug ID
DR0269
ACDINA Drug ID
D00096

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Angiotensin-converting enzyme (ACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [10]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [11]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [12]
Moexipril DM26E4B Hypertension BA00-BA04 Approved [13]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [14]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [15]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [16]
Fosinopril DM9NJ52 Chronic heart failure BD1Z Approved [17]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [18]
Enalaprilat DMFYAM1 Congestive heart failure BD10 Approved [19]
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Drug(s) Targeting HUMAN angiotensin-converting enzyme (ACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [5]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [20]
Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [21]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [22]
Ampicillin DMHWE7P Acute epiglottitis Approved [23]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [24]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [25]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [26]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [27]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [22]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [24]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [24]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [28]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [33]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [34]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [35]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [36]
Propranolol DM79NTF Angina pectoris BA40 Approved [37]
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Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [41]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [42]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [43]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [44]
Epinephrine DM3KJBC Acute asthma CA23 Approved [45]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [46]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [47]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [48]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [49]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
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Drug(s) Affected By Kallikrein-10 (KLK10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [69]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [70]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [71]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [73]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [75]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Inhibitor [4]
HUMAN angiotensin-converting enzyme (ACE) TTGFNPD ACE_HUMAN Inhibitor [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [7]
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Kallikrein-10 (KLK10) OTD573EL KLK10_HUMAN Drug Response [9]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Drug Response [9]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Drug Response [9]

References

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