Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM50PMY)

• Drug Name: Minodronate Drug Info
• Synonyms: Minodronic acid; 180064-38-4; (1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid; Recalbon; Bonoteo; BPH 261; ONO 5920; YH 529; Phosphonic acid, (1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-; UNII-40SGR63TGL; YM 529; 40SGR63TGL; Ono-5920; NSC725590; YH-529; 127657-42-5; NCGC00183829-01; AK119862; Phosphonic acid, (1-hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bis-; (1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosphonoethyl)phosphonic acid; minodronic acid

Indication

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Approved	[1]

• Cross-matching ID:
  PubChem CID: 130956
  ChEBI ID: CHEMBL319144
  CAS Number: CAS 180064-38-4
  TTD Drug ID: DM50PMY

Molecule-Related Drug Atlas

Drug(s) Targeting Geranyltranstransferase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[4]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[4]
Alendronate	DMY2KX9	Bone Paget disease		Approved	[4]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[5]
Incadronate	DM3DSVJ	Hypercalcaemia	5B91.0	Approved	[6]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[7]
NERIDRONIC ACID	DMMPG5V	Bone disease	FC0Z	Approved	[8]
Zarnestra	DMF30HL	Acute myeloid leukaemia	2A60	Phase 3	[9]
GERANYLGERANYL DIPHOSPHATE	DMJZ0AM	Discovery agent	N.A.	Investigative	[10]
ISOPENTENYL PYROPHOSPHATE	DMTU05Y	Discovery agent	N.A.	Investigative	[10]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[12]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[14]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[15]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[16]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[17]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[18]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[21]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[12]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[22]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[23]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[14]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[15]

Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[27]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[28]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[31]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[32]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[3]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[3]
Ras-related protein Rap-1A (RAP1A)	OT5RH6TI	RAP1A_HUMAN	Post-Translational Modifications	[3]

References

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