Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5PDRB)

Drug Name
Amikacin Drug Info
Synonyms
Amicacin; Amikacina; Amikacine; Amikacinum; Amikavet; Amikin; Arikace; Briclin; Kaminax; Lukadin; Mikavir; AMIKACIN SULFATE; Amikacin Base; Amikacin Dihydrate; ANTIBIOTIC BB-K8; Amiglyde-V; Amikacin & Tumor Necrosis Factor; Amikacin (USP); Amikacina [INN-Spanish]; Amikacine [INN-French]; Amikacinum [INN-Latin]; Amikin(Disulfate); Antibiotic BB-K 8; BB-K 8; BB-K8; Amiglyde-V (TN); Amikacin (USP/INN); Amikacin [USAN:BAN:INN]; O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-6))-N(sup 3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine; O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->6))-N(3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine; O-3-Amino-3-deoxy-.alpha.-D-glucopyranosyl-(1->6)-O-[6-amino-6-deoxy-.alpha.-D-glucopyranosyl-(1->4)]-1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine; (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide; (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide; (2S)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide; 1-N-(L(-)-gamma-Amino-alpha-hydroxybutyryl)kanamycin A
Indication
Disease Entry ICD 11 Status REF
Bacteremia 1A73 Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Cholangitis Approved [1]
Cystic fibrosis CA25 Approved [1]
Escherichia coli meningitis Approved [1]
Neonatal sepsis Approved [1]
Osteomyelitis Approved [1]
Pneumonia caused by gram negative bacteria Approved [1]
Pseudomonas aeruginosa infectious disease Approved [1]
Staphylococcal pneumonia Approved [1]
Tuberculosis 1B10-1B1Z Investigative [3]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
37768
ChEBI ID
CHEBI:2637
CAS Number
CAS 37517-28-5
TTD Drug ID
DM5PDRB
INTEDE Drug ID
DR2167
ACDINA Drug ID
D00832

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tetracycline DMZA017 Acne vulgaris ED80 Approved [11]
Framycetin DMF8DNE Acute liver failure DB91 Approved [12]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [13]
Clomocycline DM0ZRMQ Bacterial infection 1A00-1C4Z Approved [14]
Spectinomycin DM0MQ35 Acute gonococcal cervicitis Approved [15]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [16]
Lymecycline DMOMLHJ Bacterial infection 1A00-1C4Z Approved [17]
Rolitetracycline DMBR5Q7 Acne vulgaris ED80 Approved [18]
Meclocycline DMSFQ8I Bacterial infection 1A00-1C4Z Approved [19]
Minocycline DMVN5OH Acne vulgaris ED80 Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Aminoglycoside O-phosphotransferase (aphA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gentamicin DMKINJO Bacteremia 1A73 Approved [5]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [5]
Framycetin DMF8DNE Acute liver failure DB91 Approved [5]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [5]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [5]
Streptomycin DME1LQN Bacterial infection 1A00-1C4Z Approved [5]
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Drug(s) Metabolized By Endoglucanase Y (EGY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gentamicin DMKINJO Bacteremia 1A73 Approved [6]
Colistin DMMD9QE Pseudomonas infection 1B92 Approved [6]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [6]
Streptomycin DME1LQN Bacterial infection 1A00-1C4Z Approved [6]
Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Haloperidol DM96SE0 Delirium Approved [7]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Selenium DM25CGV N. A. N. A. Approved [24]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [25]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [8]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [8]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Gefitinib DM15F0X Colon adenocarcinoma Approved [37]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [8]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [38]
Selenium DM25CGV N. A. N. A. Approved [39]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [40]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [41]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [8]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [8]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [8]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [8]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [8]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [8]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [43]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [46]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [47]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [48]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [8]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [49]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [50]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [53]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [54]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
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Drug(s) Affected By Extracellular calcium-sensing receptor (CASR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [59]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [60]
Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [8]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [8]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [8]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [8]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [63]
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Drug(s) Affected By Survival motor neuron protein (SMN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [64]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [65]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [66]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [67]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [68]
Arsenic DMTL2Y1 N. A. N. A. Approved [69]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [64]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [70]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [71]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [72]
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Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [8]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [8]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [8]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [8]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [8]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [8]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [8]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [8]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [73]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [8]
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Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [8]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Fluoxetine DM3PD2C Bipolar depression Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [8]
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Drug(s) Affected By Phospholipase A2 (PLA2G1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [80]
Gentamicin DMKINJO Bacteremia 1A73 Approved [7]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [7]
Dibekacin DMTX0PZ N. A. N. A. Phase 4 [7]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [81]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [82]
Rutin DMEHRAJ Discovery agent N.A. Investigative [83]
EGTA DMW9MRO Discovery agent N.A. Investigative [84]
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Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [59]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [87]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [88]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [67]
Methamphetamine DMPM4SK Anxiety Approved [89]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [90]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [91]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) TTQ8KVI F4NA87_STAAU Binder [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Aminoglycoside O-phosphotransferase (aphA6) DEWPAJD KKA6_ACIBA Substrate [5]
Endoglucanase A (EGA) DE1C8Q4 A0A660DUI5_9LACO Substrate [6]
Endoglucanase Y (EGY) DE2AZTG A0A256VAC0_LACRE Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) OT9HYT7A PLCB1_HUMAN Drug Response [7]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [8]
Catalase (CAT) OTHEBX9R CATA_HUMAN Gene/Protein Processing [9]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Gene/Protein Processing [8]
Extracellular calcium-sensing receptor (CASR) OT2PEJDO CASR_HUMAN Gene/Protein Processing [10]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Gene/Protein Processing [8]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [8]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Gene/Protein Processing [8]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [8]
Phospholipase A2 (PLA2G1B) OT1GG9FK PA21B_HUMAN Drug Response [7]

References

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