Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5PDRB)

• Drug Name: Amikacin Drug Info
• Synonyms: Amicacin; Amikacina; Amikacine; Amikacinum; Amikavet; Amikin; Arikace; Briclin; Kaminax; Lukadin; Mikavir; AMIKACIN SULFATE; Amikacin Base; Amikacin Dihydrate; ANTIBIOTIC BB-K8; Amiglyde-V; Amikacin & Tumor Necrosis Factor; Amikacin (USP); Amikacina [INN-Spanish]; Amikacine [INN-French]; Amikacinum [INN-Latin]; Amikin(Disulfate); Antibiotic BB-K 8; BB-K 8; BB-K8; Amiglyde-V (TN); Amikacin (USP/INN); Amikacin [USAN:BAN:INN]; O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-6))-N(sup 3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine; O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->6))-N(3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine; O-3-Amino-3-deoxy-.alpha.-D-glucopyranosyl-(1->6)-O-[6-amino-6-deoxy-.alpha.-D-glucopyranosyl-(1->4)]-1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine; (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide; (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide; (2S)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide; 1-N-(L(-)-gamma-Amino-alpha-hydroxybutyryl)kanamycin A

Indication

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Cholangitis		Approved	[1]
Cystic fibrosis	CA25	Approved	[1]
Escherichia coli meningitis		Approved	[1]
Neonatal sepsis		Approved	[1]
Osteomyelitis		Approved	[1]
Pneumonia caused by gram negative bacteria		Approved	[1]
Pseudomonas aeruginosa infectious disease		Approved	[1]
Staphylococcal pneumonia		Approved	[1]
Tuberculosis	1B10-1B1Z	Investigative	[3]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 37768
  ChEBI ID: CHEMBL177
  CAS Number: CAS 37517-28-5
  TTD Drug ID: DM5PDRB
  INTEDE Drug ID: DR2167
  ACDINA Drug ID: D00832

Molecule-Related Drug Atlas

Drug(s) Targeting Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[10]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[11]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[12]
Clomocycline	DM0ZRMQ	Bacterial infection	1A00-1C4Z	Approved	[13]
Spectinomycin	DM0MQ35	Acute gonococcal cervicitis		Approved	[14]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[15]
Lymecycline	DMOMLHJ	Bacterial infection	1A00-1C4Z	Approved	[16]
Rolitetracycline	DMBR5Q7	Acne vulgaris	ED80	Approved	[17]
Meclocycline	DMSFQ8I	Bacterial infection	1A00-1C4Z	Approved	[18]
Minocycline	DMVN5OH	Acne vulgaris	ED80	Approved	[19]

Drug(s) Metabolized By Aminoglycoside O-phosphotransferase (aphA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[5]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[5]
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[5]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[5]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[5]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[5]

Drug(s) Metabolized By Endoglucanase Y (EGY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[6]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[6]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[6]
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[6]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[8]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[8]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[8]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[8]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[22]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[25]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[26]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[27]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]

Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[8]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[8]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[8]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[8]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[8]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[8]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[35]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Methamphetamine	DMPM4SK	Anxiety		Approved	[38]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[39]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[40]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)	TTQ8KVI	F4NA87_STAAU	Binder	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Aminoglycoside O-phosphotransferase (aphA6)	DEWPAJD	KKA6_ACIBA	Substrate	[5]
Endoglucanase A (EGA)	DE1C8Q4	A0A660DUI5_9LACO	Substrate	[6]
Endoglucanase Y (EGY)	DE2AZTG	A0A256VAC0_LACRE	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Drug Response	[7]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[8]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[8]
PTB-containing, cubilin and LRP1-interacting protein (PID1)	OT5YJ7FI	PCLI1_HUMAN	Gene/Protein Processing	[8]
Tyrosinase	OTX54MAA	TYRO_HUMAN	Gene/Protein Processing	[9]

References

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