Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5PU6O)

Drug Name
Oxcarbazepine Drug Info
Synonyms
Epilexter; Epliga; Oxacarbazepine; Oxcarbamazepine; Oxcarbazepime; Oxcarbazepina; Oxcarbazepinum; Timox; Trileptal; Desitin brand of oxcarbazepine; Novartis brand of oxcarbazepine; Oxcarbazepine [INN]; GP 47680; O0363; GP-47680; KIN-493; Oxaleptal (TN); Oxcarbazepina [INN-Spanish]; Oxcarbazepinum [INN-Latin]; SPN-804; Trileptal (TN); Oxcarbazepine (USAN/INN); 10,11-Dihydro-10-oxo-5H-debenz(b,f)azepine-5-carboxamide; 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide; 10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide; 10,11-Dihydro-10-oxo-5H-dibenzo[b,f]azepine-5-carboxamide; 10,11-Dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide; 10-Oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide; 5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide
Indication
Disease Entry ICD 11 Status REF
Epilepsy 8A60-8A68 Approved [1]
Focal epilepsy Approved [2]
Therapeutic Class
Anticonvulsants
Cross-matching ID
PubChem CID
34312
ChEBI ID
CHEBI:7824
CAS Number
CAS 28721-07-5
TTD Drug ID
DM5PU6O
VARIDT Drug ID
DR00453
INTEDE Drug ID
DR1744
ACDINA Drug ID
D00500

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.9 (SCN11A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [10]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [11]
Lacosamide DMVM6QR Convulsion 8A68.Z Approved [12]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [13]
Tolperisone DMA2GHJ Muscle spasm MB47.3 Approved [14]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [15]
Eslicarbazepine DMZREFQ Seizure disorder 8A6Z Approved [12]
HP-184 DMNOMV2 Multiple sclerosis 8A40 Phase 2 [16]
QX-314 DMAV2FM Pain MG30-MG3Z Terminated [17]
PD-32577 DMBA15J Discovery agent N.A. Investigative [18]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
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Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [29]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [31]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Fluoxetine DM3PD2C Bipolar depression Approved [28]
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Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Fructose DM43AN2 Vomiting MD90 Approved [36]
Estrone DM5T6US Acne vulgaris ED80 Approved [37]
Testosterone DM7HUNW Hot flushes GA30 Approved [38]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [39]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [37]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [37]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [37]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [37]
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Drug(s) Affected By Carbonyl reductase 3 (CBR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [44]
Bortezomib DMNO38U Leukemia Approved [45]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Acetohexamide DMR6N7H Diabetic complication 5A2Y Approved [48]
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Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [49]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [8]
Allopurinol DMLPAOB Gout FA25 Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [53]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [54]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [55]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [56]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [57]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [58]
Diazepam DM08E9O Alcohol withdrawal Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [61]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [58]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [63]
Testosterone DM7HUNW Hot flushes GA30 Approved [64]
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Drug(s) Affected By Carbonyl reductase 1 (CBR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Testosterone enanthate DMB6871 N. A. N. A. Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [44]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [67]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [68]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [69]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [70]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [68]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [71]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [58]
Diazepam DM08E9O Alcohol withdrawal Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [73]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [74]
Ethacrynic acid DM60QMR Edema MG29 Approved [72]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [58]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [75]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [58]
Diazepam DM08E9O Alcohol withdrawal Approved [59]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [76]
Desogestrel DM27U4Y Contraception QA21 Approved [76]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
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Drug(s) Affected By Dehydrogenase/reductase SDR family member 7 (DHRS7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [44]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [81]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [82]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [83]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [75]
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Drug(s) Affected By Aldo-keto reductase family 1 member C4 (AKR1C4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [84]
Diazepam DM08E9O Alcohol withdrawal Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Benzbromarone DMC3YUA Gout FA25 Approved [85]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [59]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [59]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [86]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [87]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.9 (SCN11A) TTN9VTF SCNBA_HUMAN Blocker [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Biotransformations [5]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Biotransformations [5]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Biotransformations [5]
Aldo-keto reductase family 1 member C4 (AKR1C4) OTW2MMOF AK1C4_HUMAN Biotransformations [5]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [6]
Carbonyl reductase 1 (CBR1) OTQ3A541 CBR1_HUMAN Biotransformations [5]
Carbonyl reductase 3 (CBR3) OT9G6SF0 CBR3_HUMAN Biotransformations [5]
Dehydrogenase/reductase SDR family member 7 (DHRS7) OTV729DT DHRS7_HUMAN Biotransformations [7]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Drug Response [8]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Gene/Protein Processing [9]

References

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2 Oxcarbazepine FDA Label
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44 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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54 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
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64 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
65 Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15;72(16):4214-24.
66 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
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68 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
69 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
70 Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
71 Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
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