Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM602WT)

Drug Name
Idelalisib Drug Info
Synonyms
Idelalisib; 870281-82-6; CAL-101; Zydelig; GS-1101; CAL101; CAL 101; (S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one; UNII-YG57I8T5M0; CAL-101 (Idelalisib, GS-1101); YG57I8T5M0; CHEMBL2216870; CHEBI:82701; 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one; AK145603; Idelalisib; CAL-101; (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one; 1146702-54-6; 5-FLUORO-3-PHENYL-2-[(1S)-1-(9H-PURIN-6-YLAMINO)PROPYL]-4(3H)-QUINAZOLINONE
Indication
Disease Entry ICD 11 Status REF
Chronic lymphocytic leukaemia 2A82.0 Approved [1]
Small lymphocytic lymphoma 2A82.0 Approved [2]
Follicular lymphoma 2A80 Investigative [2]
Cross-matching ID
PubChem CID
11625818
ChEBI ID
CHEBI:82701
CAS Number
CAS 870281-82-6
TTD Drug ID
DM602WT
VARIDT Drug ID
DR00219
INTEDE Drug ID
DR0854
ACDINA Drug ID
D00322

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting PI3-kinase delta (PIK3CD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAY 80-6946 DMLOS5R Follicular lymphoma 2A80 Approved [10]
Umbralisib DMYRBO1 Follicular lymphoma 2A80 Approved [11]
IPI-145 DMWA24P Follicular lymphoma 2A80 Approved [12]
Leniolisib DMWAD93 Stomach cancer 2B72 Approved [13]
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [14]
INCB50465 DMZJP2T Diffuse large B-cell lymphoma 2A81 Phase 2 [15]
ME-401 DMK0UOY Follicular lymphoma 2A80 Phase 2 [15]
RP6530 DMYILGK Chronic lymphocytic leukaemia 2A82.0 Phase 2 [15]
Parsaclisib DMYBIFS Follicular lymphoma 2A80 Phase 2 [16]
AZD8154 DMK13L1 Asthma CA23 Phase 2 [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
Folic Acid DMEMBJC Colorectal carcinoma Approved [20]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [26]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [28]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [36]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [37]
Fructose DM43AN2 Vomiting MD90 Approved [38]
Ketoprofen DMRKXPT Bursitis Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [40]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [41]
Gefitinib DM15F0X Colon adenocarcinoma Approved [42]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Gefitinib DM15F0X Colon adenocarcinoma Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [47]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [48]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Epinephrine DM3KJBC Acute asthma CA23 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Fructose DM43AN2 Vomiting MD90 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [61]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [62]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [69]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [70]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [71]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Prednisone DM2HG4X Acute asthma CA23 Approved [74]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [74]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [75]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [76]
Epinephrine DM3KJBC Acute asthma CA23 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Fluoxetine DM3PD2C Bipolar depression Approved [78]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [79]
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Drug(s) Affected By Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [81]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [82]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [83]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [81]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [87]
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Drug(s) Affected By RNA cytidine acetyltransferase (NAT10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [90]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [91]
Benzatropine DMF7EXL Parkinsonian disorder Approved [92]
Clozapine DMFC71L Schizophrenia 6A20 Approved [92]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [93]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [8]
Arsenic DMTL2Y1 N. A. N. A. Approved [94]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [95]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase delta (PIK3CD) TTGBPJE PK3CD_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Gene/Protein Processing [6]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Gene/Protein Processing [6]
Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1) OTWE5G4T P3IP1_HUMAN Gene/Protein Processing [7]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [7]
RNA cytidine acetyltransferase (NAT10) OT6JQO26 NAT10_HUMAN Gene/Protein Processing [8]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Protein Interaction/Cellular Processes [9]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Protein Interaction/Cellular Processes [9]

References

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2 Idelalisib FDA Label
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72 Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
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75 NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. Int J Cancer. 2009 Jan 1;124(1):223-32. doi: 10.1002/ijc.23934.
76 Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. J Cardiovasc Pharmacol. 2008 Mar;51(3):267-73. doi: 10.1097/FJC.0b013e3181624b44.
77 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
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80 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
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