Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6034S)

Drug Name
Selegiline Drug Info
Synonyms
selegiline; L-Deprenalin; Emsam; (-)-selegiline; Selegilinum; Selegilina; Carbex; 14611-51-9; Selegilinum [INN-Latin]; Selegilina [INN-Spanish]; UNII-2K1V7GP655; l-E 250; CHEMBL972; CHEBI:9086; N-methyl-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-amine; 2K1V7GP655; (R)-(-)-N,alpha-Dimethyl-N-2-propinylphenethylamine; Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, (R)-; selgene; (R)-(-)-N-Methyl-N-(1-phenyl-2-propyl)-2-propinylamin; Selegyline; Zalapar; Selegiline (transdermal, Parkinson's/depression); Zunrisa/Rezonic
Indication
Disease Entry ICD 11 Status REF
Major depressive disorder 6A70.3 Approved [1]
Skin imperfections EK71 Patented [2]
Chemotherapy-induced nausea MD90 Discontinued in Phase 3 [3]
Cross-matching ID
PubChem CID
26757
ChEBI ID
CHEBI:9086
CAS Number
CAS 14611-51-9
TTD Drug ID
DM6034S
ACDINA Drug ID
D00618

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Substance-P receptor (TACR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aprepitant DM053KT Depression 6A70-6A7Z Approved [11]
Rolapitant DM8XP26 Chemotherapy-induced nausea MD90 Approved [12]
Netupitant DMEKAYI Chemotherapy-induced nausea MD90 Phase 3 [12]
Serlopitant DM5VH6U Prurigo nodularis EC91.0 Phase 3 [13]
LY-686017 DM7WORZ Atopic dermatitis EA80 Phase 3 [14]
Elinzanetant DMC6EFI Hot flushes GA30 Phase 3 [15]
CP-122721 DMSWLM5 Major depressive disorder 6A70.3 Phase 2 [16]
FR139317 DMEL5SV Hypertension BA00-BA04 Phase 2 [5]
VOFOPITANT HYDROCHLORIDE DMQMYP5 Vomiting MD90 Phase 2 [17]
LY-2590443 DM81UJW Migraine 8A80 Phase 2 [18]
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Drug(s) Targeting Monoamine oxidase (MAO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Moclobemide DMNZWL7 Depression 6A70-6A7Z Approved [2]
Phenelzine DMHIDUE Depression 6A70-6A7Z Approved [2]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [2]
Methylene blue DMJAPE7 Acquired methemoglobinemia 3A93 Approved [19]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [2]
Pargyline DMM0HR1 Hypertension BA00-BA04 Approved [2]
Ergoloid mesylate DMORPBA Alzheimer disease 8A20 Approved [20]
Cyclopropylamine derivative 11 DMMJ0YN N. A. N. A. Patented [21]
PMID27019002-Compound-20a DMRX748 N. A. N. A. Patented [21]
Cyclopropylamine derivative 9 DMX7YAL N. A. N. A. Patented [21]
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Drug(s) Targeting Monoamine oxidase type B (MAO-B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selegiline Hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [22]
Phenelzine DMHIDUE Depression 6A70-6A7Z Approved [23]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [24]
Safinamide mesylate DM0J2ZT Parkinson disease 8A00.0 Approved [25]
Rasagiline DM3WKQ4 Parkinson disease 8A00.0 Approved [26]
Sulphadoxine DMZI2UF Malaria 1F40-1F45 Approved [27]
Pargyline DMM0HR1 Hypertension BA00-BA04 Approved [28]
Indeloxazine DMWO3N6 Dementia 6D80-6D86 Approved [29]
Budipine DMODHQI Migraine 8A80 Approved [30]
Safinamide DM0YWJC Parkinson disease 8A00.0 Approved [31]
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Drug(s) Affected By Amine oxidase B (MAOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
BENZYL BENZOATE DMDPYI5 Infestations of lice and scabies 1G00.Z Approved [39]
Linezolid DMGFPU2 Bacteremia 1A73 Approved [40]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [35]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [41]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [42]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [43]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [44]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [45]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [46]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [47]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [48]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [49]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [50]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [53]
Gefitinib DM15F0X Colon adenocarcinoma Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [56]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [57]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [61]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [62]
Fructose DM43AN2 Vomiting MD90 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [65]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
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Drug(s) Affected By Amine oxidase A (MAOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
BENZYL BENZOATE DMDPYI5 Infestations of lice and scabies 1G00.Z Approved [39]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [77]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [84]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [75]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [85]
Paclitaxel DMLB81S Breast carcinoma Approved [86]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [87]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [77]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [78]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [89]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [89]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [89]
Capsaicin DMGMF6V Back pain ME84.Z Approved [90]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [91]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [92]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [93]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [94]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [95]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [63]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Monoamine oxidase (MAO) TT32XQJ NOUNIPROTAC Inhibitor [2]
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [4]
Substance-P receptor (TACR1) TTZPO1L NK1R_HUMAN Antagonist [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Gene/Protein Processing [6]
Amine oxidase B (MAOB) OTTDFM1O AOFB_HUMAN Gene/Protein Processing [7]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Regulation of Drug Effects [8]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Gene/Protein Processing [9]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [10]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [10]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Post-Translational Modifications [10]
Thioredoxin OT6XU6VW THIO_HUMAN Gene/Protein Processing [10]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Gene/Protein Processing [10]

References

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