Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6DEK9)

Drug Name
Stavudine Drug Info
Synonyms
DdeThd; DdeTyd; Dideoxydidehydrothymidine; Estavudina; STV; Sanilvudine; Stavudinum; Zent; Zerit; Zerit Xr; Zerut XR; BMY 27857; BMY27857; D 1413; D 4T; BMY-27857; Bristol-Myers Brand of Stavudine; Bristol-Myers Squibb Brand of Stavudine; D 4T (nucleoside); Estavudina [INN-Spanish]; Sanilvudine (JAN); Stavudine, Monosodium Salt; Stavudinum [INN-Latin]; Zerit (TN); Zerit(TM); D4T & GM-CSF; D4TMBY-27857-3; Stavudine (USAN/INN); Stavudine [USAN:BAN:INN]; Stavudine [USAN:INN:BAN]; Thymine, 1-(2,3-dideoxy-beta-D-glycero-pent-2-enofuranosyl)-(7CI,8CI); 1-(2,3-Dideoxy-beta-D-glycero-2-pentenofuranosyl)thymine; 1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine; 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione; 1-[5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione & Colony-stimulating factor 2; 2',3' Didehydro 3' deoxythymidine; 2',3'-Anhydrothymidine; 2',3'-DIDEHYDRO-3'-DEOXYTHYMIDINE (DDI); 2',3'-Didehydro-2',3'-dideoxythmidine; 2',3'-Didehydro-3'-deoxythimidine; 2',3'-Didehydro-3'-deoxythymidine; 3'-Azido-3'-deoxythymidine & Granulocyte-macrophage colony-stimulating factor; 3'-Deoxy-2',3'-didehydrothymidine; 3'-Deoxy-2'-thymidinene; D4T
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [1]
Therapeutic Class
Anti-HIV Agents
Cross-matching ID
PubChem CID
18283
ChEBI ID
CHEBI:63581
CAS Number
CAS 3056-17-5
TTD Drug ID
DM6DEK9
ACDINA Drug ID
D00639

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [10]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [11]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [12]
Tenofovir DM1IS6U Chronic hepatitis B virus infection Approved [10]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [13]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [14]
Delavirdine DM3NF5G Human immunodeficiency virus infection 1C62 Approved [13]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [13]
Rilpivirine DMJ0QOW Human immunodeficiency virus infection 1C62 Approved [15]
Etravirine DMGV8QU Human immunodeficiency virus-1 infection 1C62 Approved [16]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [17]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [18]
Fructose DM43AN2 Vomiting MD90 Approved [19]
Ketoprofen DMRKXPT Bursitis Approved [19]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [21]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [22]
Gefitinib DM15F0X Colon adenocarcinoma Approved [23]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Gefitinib DM15F0X Colon adenocarcinoma Approved [28]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [29]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [29]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [31]
Selenium DM25CGV N. A. N. A. Approved [32]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [33]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [34]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [35]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [19]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [36]
Diazepam DM08E9O Alcohol withdrawal Approved [37]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [38]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [39]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [40]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [44]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [45]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [47]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [4]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [31]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [49]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [51]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [52]
Cepharanthine DM9Y5JB N. A. N. A. Approved [53]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [54]
Clozapine DMFC71L Schizophrenia 6A20 Approved [55]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [56]
Trifluoperazine DMKBYWI Anxiety Approved [57]
Olanzapine DMPFN6Y Bipolar depression Approved [55]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [58]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [61]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [19]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Verapamil DMA7PEW Angina pectoris BA40 Approved [62]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [63]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [21]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [64]
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Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Etretinate DM2CZFA Keratosis ED56 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [3]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [71]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [4]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Gefitinib DM15F0X Colon adenocarcinoma Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [76]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [77]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [78]
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
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Drug(s) Affected By Lon protease homolog, mitochondrial (LONP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [3]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [87]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [88]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [89]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [93]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [96]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [99]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [100]
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Drug(s) Affected By Leptin (LEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [103]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [4]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [100]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [104]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [105]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [100]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [106]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Gefitinib DM15F0X Colon adenocarcinoma Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [3]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [111]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [109]
Ethacrynic acid DM60QMR Edema MG29 Approved [112]
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Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [4]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [4]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [113]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [114]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [4]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [100]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [117]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
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Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [3]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [121]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [122]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [120]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [123]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [125]
Urethane DM7NSI0 N. A. N. A. Phase 4 [126]
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Drug(s) Affected By Equilibrative nucleoside transporter 3 (SLC29A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [129]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [121]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [123]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [88]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [130]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [9]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human immunodeficiency virus Reverse transcriptase (HIV RT) TT84ETX POL_HV1B1 Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Gene/Protein Processing [3]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Gene/Protein Processing [4]
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [5]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [6]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [7]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [4]
Dicarboxylate carrier SLC25A8 OTA556MK UCP2_HUMAN Gene/Protein Processing [8]
Equilibrative nucleoside transporter 3 (SLC29A3) OTGLX8XU S29A3_HUMAN Regulation of Drug Effects [9]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [4]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [4]

References

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