Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7NKEV)

Drug Name

Thioguanine Drug Info

Synonyms

6-thioguanine; Lanvis; THG; Tabloid; ThioguaninGSK; Tioguanin; Tioguanina; Tioguanine; Tioguaninum; Glaxo Wellcome Brand of Thioguanine; Glaxo Wellcome Brand of Tioguanine; GlaxoSmithKline Brand of Thioguanine; GlaxoSmithKline Brand of Tioguanine; Thioguanin GSK; Thioguanine Hemihydrate; Thioguanine Monosodium Salt; Thioguanine Tabloid; Tioguanina Wellcome; Tioguanine GlaxoSmithKline Brand; Wellcome Brand of Thioguanine; BW 5071; DX4; LT00455187; Wellcome U3B; Lanvis (TN); Thioguanin-GSK; Thioguanine [USAN:BAN]; Tioguanina[INN-Spanish]; Tioguanine (INN); Tioguaninum [INN-Latin]; Purine antimetabolite: antimetabolite: inhibits nucleic acid replication; Guanine, thio-(VAN); 2 Amino 6 Purinethiol; 2-Amino 6MP; 2-Amino-1,7-dihydro-6H-purin-6-thion; 2-Amino-1,7-dihydro-6H-purin-6-thion [Czech]; 2-Amino-1,7-dihydro-6H-purine-6-thione; 2-Amino-6-MP; 2-Amino-6-mercaptopurine; 2-Amino-6-merkaptopurin; 2-Amino-6-merkaptopurin [Czech]; 2-Amino-6-purinethiol; 2-Amino-9H-purine-6-thiol; 2-Aminopurin-6-thiol; 2-Aminopurin-6-thiol [Czech]; 2-Aminopurine-6(1H)-thione; 2-Aminopurine-6-thiol; 2-Thioguanine; 2-amino-3,7-dihydropurine-6-thione; 6 Thioguanine; 6-Mercapto-2-aminopurine; 6-Mercaptoguanine; 6-TG; 6-Thioguanine; 6-Thioguanine (6-TG); 6-Thioguanine, Thioguanine; Thioguanine (Guanine analog)

Indication

Disease Entry	ICD 11	Status	REF
Acute lymphocytic leukaemia	2B33.3	Approved	[1]
Acute myelogenous leukaemia	2A41	Approved	[2]
Acute myeloid leukaemia	2A60	Approved	[3]
Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[4]
Severe acute respiratory syndrome (SARS)	1D65	Preclinical	[4]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 2723601
ChEBI ID: CHEBI:9555
CAS Number: CAS 154-42-7
TTD Drug ID: DM7NKEV
VARIDT Drug ID: DR00510
INTEDE Drug ID: DR1597
ACDINA Drug ID: D00671

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting MERS-CoV papain-like proteinase (PL-PRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[20]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[4]
Mycophenolic acid	DMRBMAU	Crohn disease	DD70	Approved	[21]
PMID30940566-compound-6	DMXCKL9	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[22]
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Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase (IMPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enteric-coated mycophenolate sodium	DMK659W	Transplant rejection	NE84	Approved	[23]
VX-944	DME321B	Solid tumour/cancer	2A00-2F9Z	Phase 2	[24]
IMS	DMFACQU	Inflammatory bowel disease	DD72	Discontinued in Phase 1	[25]
R-1518	DM2J5AO	Hepatitis C virus infection	1E51.1	Discontinued in Phase 1	[26]
EPB-415	DMBLSX3	Hepatitis C virus infection	1E51.1	Investigative	[27]
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Drug(s) Targeting SARS-CoV papain-like proteinase (PL-PRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[20]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[4]
GRL-0667	DML09OS	Severe acute respiratory syndrome (SARS)	1D65	Investigative	[28]
PMID20527968-compound-6577871	DMI30V7	Severe acute respiratory syndrome (SARS)	1D65	Investigative	[28]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[31]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[33]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[34]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[36]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[37]
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Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[39]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[40]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[42]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[43]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[44]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[46]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[42]
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Drug(s) Transported By Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[47]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[48]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[49]
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Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[54]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[55]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[56]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[57]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[58]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[59]
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Drug(s) Affected By Thiopurine S-methyltransferase (TPMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[64]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Bendroflumethiazide	DM7EVLC	High blood pressure	BA00	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[64]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Bendroflumethiazide	DM7EVLC	High blood pressure	BA00	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
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Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Fructose	DM43AN2	Vomiting	MD90	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
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Drug(s) Affected By Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[85]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[17]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[88]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[89]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[90]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[93]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
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Drug(s) Affected By Dystrophin (DMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[98]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[99]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[100]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[101]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[100]
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Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[108]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[109]
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Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[114]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[115]
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Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[11]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[40]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[118]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
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Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[124]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[135]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[138]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inosine-5'-monophosphate dehydrogenase (IMPDH)	TTCAQMW	NOUNIPROTAC	Intercalator	[5]
MERS-CoV papain-like proteinase (PL-PRO)	TTYJOLE	R1AB_CVEMC (854-2740)	Inhibitor	[4]
SARS-CoV papain-like proteinase (PL-PRO)	TTRGHB2	R1AB_CVHSA (819-2740)	Inhibitor	[4]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3)	DT4YL5R	S28A3_HUMAN	Substrate	[6]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[7]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[8]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Hypoxanthine phosphoribosyltransferase (HPRT1)	DEVXTP5	HPRT_HUMAN	Substrate	[9]
Thiopurine methyltransferase (TPMT)	DEFQ8VO	TPMT_HUMAN	Substrate	[10]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Drug Response	[11]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Drug Response	[12]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Drug Response	[13]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[13]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Drug Response	[14]
Dystrophin (DMD)	OTD21T5J	DMD_HUMAN	Gene/Protein Processing	[15]
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)	OTOEEEXG	HPRT_HUMAN	Drug Response	[16]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)	OTPG0K7E	IMDH2_HUMAN	Gene/Protein Processing	[17]
Occludin (OCLN)	OTSUTVWL	OCLN_HUMAN	Gene/Protein Processing	[18]
Thiopurine S-methyltransferase (TPMT)	OTFOX70W	TPMT_HUMAN	Drug Response	[19]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Thioguanine FDA Label
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6845).
4	Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antiviral Res. 2015 Mar;115:9-16.
5	Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. Cancer Res. 2009 Mar 15;69(6):2393-9.
6	Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochem Biophys Res Commun. 2006 Apr 28;343(1):208-15.
7	Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. Int J Biochem Cell Biol. 2004 Feb;36(2):247-57.
8	ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol. 2012 Apr 15;83(8):1073-83.
9	Qualitative and quantitative difference in mutation induction between carbon- and neon-ion beams in normal human cells. Biol Sci Space. 2003 Dec;17(4):302-6.
10	Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases. Acta Gastroenterol Belg. 2010 Jul-Sep;73(3):331-5.
11	The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Mol Cancer Ther. 2005 May;4(5):855-63.
12	Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res. 2000 May;6(5):1796-803.
13	Important role of caspase-8 for chemosensitivity of ALL cells. Clin Cancer Res. 2011 Dec 15;17(24):7605-13. doi: 10.1158/1078-0432.CCR-11-0513. Epub 2011 Oct 18.
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