General Information of Drug (ID: DMA5XGH)

Drug Name
Isradipine Drug Info
Synonyms
Clivoten; DynaCirc; DynaCire; Dynacrine; Esradin; Icaz; Isradipin; Isradipino; Isradipinum; Isrodipine; Lomir; Prescal; Rebriden; DynaCire CR; Dynacirc CR; Isradipino [Spanish]; Isradipinum [Latin]; PN 205 033; PN 205 034; PN 205033; PN 205034; PN205033; PN205034; DynaCirc (TN); PN 200-110; PN 205-033; PN 205-034; PN-200110; Prescal (TN); Isradipine (USP/INN); Isradipine [USAN:INN:BAN]; PN-200-110; PN-205-033; PN-205-034; Isradipine, (R)-Isomer; Isradipine, (S)-Isomer; Isradipine, (+-)-Isomer; DynaCirc, Prescal, PN-200-110, Clivoten, Esradin, Isradipine; Isopropyl methyl (+-)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate; Isopropyl 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylate; Methyl 1-methylethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; O5-methyl O3-propan-2-yl 4-(2,1,3-benzoxadiazol-7-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (+-)-Isradipine; (+/-)-Isradipine; 2,1,3-Benzoxadiazole, 3,5-pyridinedicarboxylic acid deriv.; 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester; 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester; 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester (9CI); 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester; 3-O-methyl 5-O-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 4-(2,1,3-Benzooxadiazol-4-yl)-2.6-dimethyl-1,4-dihydro-3-isopropyloxycarbonylpyridine-5-carboxylic Acid Methyl Ester; 4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methhylethyl ester; 4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester; 4-(4-Benzofurazanyl)-1,4-dihydro-2,-6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [1]
Herpes simplex virus infection 1F00 Phase 3 [2]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
3784
ChEBI ID
CHEBI:6073
CAS Number
CAS 75695-93-1
TTD Drug ID
DMA5XGH
VARIDT Drug ID
DR00975
ACDINA Drug ID
D00336

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicardipine DMCDYW7 High blood pressure BA00 Approved [8]
Clevidipine butyrate DMW4M97 Hypertension BA00-BA04 Approved [9]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [10]
Felodipine DMOSW35 Hypertension BA00-BA04 Approved [11]
Nimodipine DMQ0RKZ Cerebral vasospasm BA85.Z Approved [12]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [3]
DIPROTEVERINE HYDROCHLORIDE DMG8U6M Angina pectoris BA40 Phase 3 [13]
ATI-2042 DMWP59B Atrial fibrillation BC81.3 Phase 2 [14]
HBI-3000 DM74ZKN Heart arrhythmia BC65 Phase 2 [15]
Nexopamil DML5S71 Hypertension BA00-BA04 Phase 2 [16]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [17]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [5]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [5]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [18]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [17]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [5]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [19]
Gefitinib DM15F0X Colon adenocarcinoma Approved [17]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [20]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [17]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [21]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [21]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [22]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [24]
Etidronic acid DM1XHYJ Bone Paget disease Approved [21]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [21]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [21]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [25]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [27]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [6]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [28]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Ethacrynic acid DM60QMR Edema MG29 Approved [32]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [33]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [34]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [35]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [36]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [36]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [36]
Capsaicin DMGMF6V Back pain ME84.Z Approved [37]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [38]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [39]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [40]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [41]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [42]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [43]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [46]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [47]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [48]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [49]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [50]
Capsaicin DMGMF6V Back pain ME84.Z Approved [51]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [52]
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Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [53]
Methoxsalen DME8FZ9 Cutaneous T-cell lymphoma 2B01 Approved [54]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [57]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [58]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [61]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [48]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [47]
Capsaicin DMGMF6V Back pain ME84.Z Approved [37]
Zafirlukast DMHNQOG Asthma CA23 Approved [64]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [48]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [65]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [47]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [66]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [67]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [68]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [69]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [70]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [71]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [72]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [73]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [74]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [78]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [79]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [84]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [86]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [87]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [88]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [89]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [90]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [91]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [92]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [93]
Epinephrine DM3KJBC Acute asthma CA23 Approved [94]
Chlorthalidone DM4DMBT Edema MG29 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [97]
Diazepam DM08E9O Alcohol withdrawal Approved [98]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [99]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [100]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [107]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [108]
Estrone DM5T6US Acne vulgaris ED80 Approved [109]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [110]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [111]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [112]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [113]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [114]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calcium channel unspecific (CaC) TT5HONZ NOUNIPROTAC Modulator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [4]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [5]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [4]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [4]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [6]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Gene/Protein Processing [4]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [4]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Protein Interaction/Cellular Processes [7]

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