Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAY7H4)

Drug Name
Valdecoxib Drug Info
Synonyms
Bextra; COX; Kudeq; Valdyn; Pfizer brand of valdecoxib; Valdecoxib [USAN]; SC 65872; ND-0214; SC-65872; YM-974; Valdecoxib (USAN/INN); P-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; Benzenesulfonamide, 4-(5-methyl-3-phenyl-4-isoxazolyl)-(9CI); 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide; 4-(5-methyl-3-phenyl-4-isoxazolyl) benzenesulfonamide; 4-(5-methyl-3-phenyl-isoxazol-4-yl)benzenesulfonamide; 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-(Methyl-3-phenyl-isoxazol-4-yl)-benzenesulfonamide
Indication
Disease Entry ICD 11 Status REF
Osteoarthritis FA00-FA05 Approved [1]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
119607
ChEBI ID
CHEBI:63634
CAS Number
CAS 181695-72-7
TTD Drug ID
DMAY7H4
VARIDT Drug ID
DR01196
INTEDE Drug ID
DR1666

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [10]
Naproxen DMZ5RGV Bursitis Approved [11]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [12]
Indomethacin DMSC4A7 Bursitis Approved [13]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [14]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [15]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [16]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [17]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [18]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [13]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [20]
Verapamil DMA7PEW Angina pectoris BA40 Approved [5]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [33]
Estrone DM5T6US Acne vulgaris ED80 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [37]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [5]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [39]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [5]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [5]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [40]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [5]
Haloperidol DM96SE0 Delirium Approved [5]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [41]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [42]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [45]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [46]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [47]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [48]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [51]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [6]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [52]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [55]
Ethacrynic acid DM60QMR Edema MG29 Approved [56]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [57]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [58]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [59]
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Drug(s) Affected By Fibroblast growth factor 2 (FGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Diazepam DM08E9O Alcohol withdrawal Approved [62]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [63]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [67]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [69]
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Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [70]
Fluoxetine DM3PD2C Bipolar depression Approved [8]
Cinoxacin DM4EWNS Urinary tract infection GC08 Approved [8]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Testosterone DM7HUNW Hot flushes GA30 Approved [73]
Testosterone enanthate DMB6871 N. A. N. A. Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [8]
Aztreonam DMDNJHG Bacterial infection 1A00-1C4Z Approved [8]
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Drug(s) Affected By HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [8]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ethosuximide DMDZ9LT Epilepsy 8A60-8A68 Approved [8]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [78]
Vancomycin DM3JFIH Bacteremia 1A73 Approved [8]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [79]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [80]
Bortezomib DMNO38U Leukemia Approved [81]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [8]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [83]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [84]
Estrone DM5T6US Acne vulgaris ED80 Approved [85]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [86]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [87]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [88]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [89]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [90]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 2C9 (CYP2C9) Main DME DE5IED8 CP2C9_HUMAN Substrate [4]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [6]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [6]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Protein Interaction/Cellular Processes [7]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Gene/Protein Processing [8]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Gene/Protein Processing [8]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Gene/Protein Processing [9]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Protein Interaction/Cellular Processes [7]

References

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