Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB08GE)

Drug Name

Sulfamethoxazole Drug Info

Synonyms

sulfamethoxazole; 723-46-6; Gantanol; Sulphamethoxazole; Sulfisomezole; Sulfamethoxazol; Metoxal; Sulfamethylisoxazole; Simsinomin; Radonil; Sinomin; Sulphamethoxazol; 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide; Sulpha-methoxizole; Sulfamethalazole; Azo-gantanol; Sulphamethylisoxazole; Urobak; Sulfamethoxizole; 3-Sulfanilamido-5-methylisoxazole; Gantanol-DS; 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide; Bactrimel; Gamazole; Sulphisomezole; Sulfametoxazol; Solfametossazolo; Sulfamethoxazolum; Ro 4-2130; SMX; Septran; Sulphamethalazole; Trib; Solfametossazolo [DCIT]; Sulfamethoxazole sodium; MS 53; Sulphamethoxazole BP 98; ALBB-002089; Apo-Sulfamethoxazole; Bactrim (TN); Septra (TN); Septrin (TN); Sulfamethoxazolum [INN-Latin]; Sulfametoxazol [INN-Spanish]; Ro 6-2580/11; Ro-4-2130; Sulfamethoxazole [USAN:INN:JAN]; Sulfamethoxazole (JP15/USP/INN); N1-(5-Methyl-3-isoxazolyl)sulfanilamide; N1-(5-Methylisoxazol-3-yl)sulfanilamide; SULFAMETHOXAZOLE (8064-90-2 (TRIMETHOPRIM/SULFAMETHOXAZOLE); N'-(5-Methyl-3-isoxazole)sulfanilamide; N'-(5-Methyl-3-isoxazolyl)sulfanilamide; N'-(5-Methylisoxazol-3-yl)sulphanilamide; N(sup 1)-(5-Methyl-3-isoxazolyl)sulfanilamide; N(sup 1)-(5-Methyl-3-isoxazolyl)sulphanilamide; N(sup1)-(5-Methyl-3-isoxazolyl)sulfanilamide; Sulfanilamide, N1-(5-methyl-3-isoxazolyl)-(8CI); 3-(p-Aminophenylsulfonamido)-5-methylisoxazole; 3-(para-Aminophenylsulphonamido)-5-methylisoxazole; 3-Sulphanilamido-5-methylisoxazole; 4-Amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide; 4-Amino-N-[5-methyl-3-isoxazolyl]benzenesulfonamide; 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide; 5-Methyl-3-sulfanilamidoisoxazole; 5-Methyl-3-sulfanylamidoisoxazole; 5-Methyl-3-sulphanil-amidoisoxazole; Sulphameth oxazole

Indication

Disease Entry	ICD 11	Status	REF
Acute otitis media	AB00	Approved	[1]
Bacillary dysentery	1A02	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Inclusion conjunctivitis		Approved	[1]
Pneumocystis pneumonia	CA40.20	Approved	[1]
Tuberculosis	1B10-1B14	Approved	[1]
Infection of P. falciparum	1F40	Investigative	[3]

Therapeutic Class

Antiinfective Agents

Cross-matching ID

PubChem CID: 5329
ChEBI ID: CHEBI:9332
CAS Number: CAS 723-46-6
TTD Drug ID: DMB08GE
VARIDT Drug ID: DR01206
INTEDE Drug ID: DR1511

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial Dihydropteroate synthetase (Bact folP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[16]
Doripenem	DM9UCJK	Cholecystitis		Approved	[17]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[18]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[19]
Sulfisoxazole	DMXLT8C	Acute otitis media	AB00	Approved	[20]
Sulfapyridine	DMIUYFH	Dermatitis herpetiformis	EB44	Approved	[21]
Gramicidin D	DMPT74U	Bacterial infection	1A00-1C4Z	Approved	[22]
Oritavancin	DM28D05	Bacterial infection	1A00-1C4Z	Approved	[17]
Faropenem	DMX7A5V	Gram-positive bacterial infection	1B74-1G40	Approved	[17]
Daptomycin	DMFDQ3I	Bacterial infection	1A00-1C4Z	Approved	[23]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[25]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[25]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[8]
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Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[32]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[33]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[34]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[35]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[36]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[37]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[38]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[39]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[40]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[41]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[44]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[45]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[46]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[47]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[43]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[48]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[49]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[50]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[44]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[54]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[55]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[59]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[61]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[8]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[62]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[8]
Haloperidol	DM96SE0	Delirium		Approved	[8]
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Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[8]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[8]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[8]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[8]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[8]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[8]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[8]
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Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[64]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[73]
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Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[77]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[80]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[81]
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Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[82]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[83]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[84]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[85]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[86]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[87]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[91]
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Drug(s) Affected By Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[15]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
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Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[102]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[105]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[106]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[108]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[109]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[111]
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Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[114]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[12]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[12]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[115]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[114]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[12]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[116]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[114]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[117]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[114]
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Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain G (HLA-G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[13]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[13]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[13]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[13]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[13]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Dihydropteroate synthetase (Bact folP)	TT4ILYC	DHPS_ECOLI	Inhibitor	[4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[6]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[7]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Substrate	[8]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DE85D2P	UD19_HUMAN	Substrate	[8]
RNA cytidine acetyltransferase (hALP)^{Main DME}	DEZV4AP	NAT10_HUMAN	Substrate	[9]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Drug Response	[10]
Arylamine N-acetyltransferase 2 (NAT2)	OTBPDQOY	ARY2_HUMAN	Regulation of Drug Effects	[11]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[12]
HLA class I histocompatibility antigen, alpha chain G (HLA-G)	OTMLK1KN	HLAG_HUMAN	Gene/Protein Processing	[13]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Protein Interaction/Cellular Processes	[14]
Myeloperoxidase (MPO)	OTOOXLIN	PERM_HUMAN	Drug Response	[10]
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)	OTUG4BWA	PAHX_HUMAN	Gene/Protein Processing	[15]
Pirin (PIR)	OT8ALXHU	PIR_HUMAN	Gene/Protein Processing	[14]

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20	Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63.
21	A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim an... J Chromatogr A. 2009 Nov 13;1216(46):8110-6.
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23	Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol. 2004 Jul;11(7):949-57.
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