Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBDAZV)

Drug Name
Amlodipine Drug Info
Synonyms
Amlocard; Amlodipino; Amlodipinum; Amlodis; Amlopres; Amlor; Coroval; Intervask; Lipinox; AMLODIPINE BASE; Amlodipine Free Base; Amlodipino [Spanish]; Amlodipinum [Latin]; Racemic Amlodipine; Amlodipine (INN); Amlodipine [INN:BAN]; Dailyvasc (TN); Istin (TN); Norvasc (TN); Perivasc (TN); UK-4834011; R,S)-Amlodipine; 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl); 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester; 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester; 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; 3-Ethyl-5-methyl (+/-)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; 3-Ethyl-5-methyl (-)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat; 3-Ethyl-5-methyl (-)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Indication
Disease Entry ICD 11 Status REF
Angina pectoris BA40 Approved [1]
Chronic heart failure BD1Z Approved [1]
Hypertension BA00-BA04 Approved [2]
Malignant essential hypertension BA00 Approved [1]
Stroke 8B20 Investigative [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
2162
ChEBI ID
CHEBI:2668
CAS Number
CAS 88150-42-9
TTD Drug ID
DMBDAZV
VARIDT Drug ID
DR00563
INTEDE Drug ID
DR0099
ACDINA Drug ID
D00033

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diltiazem DMAI7ZV Angina pectoris BA40 Approved [13]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [14]
Lercanidipine DMPWSEM Hypertension BA00-BA04 Approved [15]
Pregabalin DMDVP3B Chronic obstructive pulmonary disease CA22 Approved [16]
Mirogabalin DM5GIWZ Peripheral neuropathy 8C0Z Registered [17]
Imagabalin DMRLVUD Generalized anxiety disorder 6B00 Phase 3 [18]
NP-118809 DM8A64W Pain MG30-MG3Z Discontinued in Phase 2 [19]
PD-144550 DM03526 Discovery agent N.A. Investigative [20]
3-Aminomethyl-5-methyl-hexanoic acid DMTYXH1 Discovery agent N.A. Investigative [20]
(S)-2-amino-3-cyclohexylpropanoic acid DM1GBX8 Discovery agent N.A. Investigative [21]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [26]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [28]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [29]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [23]
Verapamil DMA7PEW Angina pectoris BA40 Approved [30]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [31]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [9]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [32]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [33]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Ethacrynic acid DM60QMR Edema MG29 Approved [36]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [37]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [38]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [39]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [40]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [41]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [42]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [43]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [44]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [45]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [46]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [47]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [48]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [49]
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Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [53]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [55]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Fluoxetine DM3PD2C Bipolar depression Approved [52]
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Drug(s) Affected By Cytochrome P450 2J2 (CYP2J2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [10]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [61]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [10]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [64]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [64]
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Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [69]
Estrone DM5T6US Acne vulgaris ED80 Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [71]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [72]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [73]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [77]
Prednisone DM2HG4X Acute asthma CA23 Approved [78]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [79]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
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Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Epinephrine DM3KJBC Acute asthma CA23 Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [83]
Fructose DM43AN2 Vomiting MD90 Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [86]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [87]
Propranolol DM79NTF Angina pectoris BA40 Approved [88]
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
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Drug(s) Affected By Platelet basic protein (PPBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [90]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [91]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [92]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [92]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [96]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [97]
Arsenic DMTL2Y1 N. A. N. A. Approved [98]
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Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Methotrexate DM2TEOL Anterior urethra cancer Approved [102]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [106]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [107]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [108]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [109]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Gefitinib DM15F0X Colon adenocarcinoma Approved [111]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [114]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [115]
Methotrexate DM2TEOL Anterior urethra cancer Approved [116]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [117]
Quercetin DM3NC4M Obesity 5B81 Approved [118]
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Drug(s) Affected By P-selectin (SELP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [119]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [121]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [122]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [123]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [97]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [124]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [125]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [126]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [127]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [128]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Fluoxetine DM3PD2C Bipolar depression Approved [129]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [133]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [134]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [135]
Selenium DM25CGV N. A. N. A. Approved [136]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [128]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [137]
Methotrexate DM2TEOL Anterior urethra cancer Approved [138]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [118]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [140]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [141]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [142]
Gefitinib DM15F0X Colon adenocarcinoma Approved [143]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Etretinate DM2CZFA Keratosis ED56 Approved [145]
Prednisone DM2HG4X Acute asthma CA23 Approved [146]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [128]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [147]
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Drug(s) Affected By Leptin (LEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [151]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [152]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [148]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [148]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [153]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [154]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [153]
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Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [148]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [148]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [155]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [156]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [148]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [148]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [153]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [159]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [9]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [160]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [161]
Estrone DM5T6US Acne vulgaris ED80 Approved [162]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [163]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [164]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [165]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [166]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [167]
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Drug(s) Affected By Resistin (RETN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [168]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [169]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [170]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [171]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [172]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [173]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [174]
isobutylmethylxanthine DM46F5X Discovery agent N.A. Investigative [175]
Icosapentum DMF1CM7 N. A. N. A. Investigative [176]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [177]
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Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [178]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [179]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [180]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [181]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [182]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [183]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [184]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [185]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [186]
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Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [187]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [188]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [189]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [189]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [190]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [191]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [193]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Blocker [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Gene/Protein Processing [5]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [7]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [8]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [9]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Gene/Protein Processing [8]
Cytochrome P450 2J2 (CYP2J2) OTJBTEH8 CP2J2_HUMAN Gene/Protein Processing [10]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Drug Response [11]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Gene/Protein Processing [12]

References

1 Amlodipine FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6981).
3 A first drug combination for the treatment of arterial hypertension with a calcium channel antagonist (amlodipine besylate) and an angiotensin receptor blocker (valsartan): Exforge. Rev Med Liege. 2007 Nov;62(11):688-94.
4 Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9.
5 Amlodipine improves endothelial function and metabolic parameters in patients with hypertension. Int J Cardiol. 2009 Mar 20;133(1):23-31. doi: 10.1016/j.ijcard.2007.11.058. Epub 2008 Jan 15.
6 Cell-based high-throughput screening for aromatase inhibitors in the Tox21 10K library. Toxicol Sci. 2015 Oct;147(2):446-57.
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