Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBR01X)

Drug Name
Brilinta Drug Info
Synonyms
Ticagrelor; 274693-27-5; Brilique; AZD-6140; AZD6140; AZD 6140; AR-C126532XX; UNII-GLH0314RVC; [14C]-Ticagrelor; GLH0314RVC; CHEBI:68558; (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPYL]AMINO]-5-(PROPYLTHIO)-3H-1,2,3-TRIAZOLO[4,5-D]PYRIMIDIN-3-YL]-5-(2-HYDROXYETHOXY)-1,2-CYCLOPENTANEDIOL; (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; Brilique; AR-C126532; Ticagrelor (USAN/INN); Brilinta/Brilique
Indication
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [1]
Thrombosis DB61-GB90 Approved [2]
Arterial thrombosis DB61-DD30 Phase 3 [3]
Myocardial infarction BA41-BA43 Phase 3 [3]
Peripheral vascular disease BD4Z Investigative [4]
Cross-matching ID
PubChem CID
9871419
ChEBI ID
CHEMBL398435
CAS Number
CAS 274693-27-5
TTD Drug ID
DMBR01X
VARIDT Drug ID
DR00077
INTEDE Drug ID
DR1591
ACDINA Drug ID
D00674

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting P2Y purinoceptor 12 (P2RY12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [11]
Prasugrel DM7MT6E Acute coronary syndrome BA41 Approved [12]
Cangrelor DM8JRH0 Thrombosis DB61-GB90 Approved [13]
INS-50589 DMKZUVC Cardiovascular disease BA00-BE2Z Phase 2 [14]
Elinogrel DMA4BRV Myocardial infarction BA41-BA43 Phase 1 [15]
ARL-67085 DMY5IM2 Thrombosis DB61-GB90 Phase 1 [16]
adenosine diphosphate DMFUHKP N. A. N. A. Investigative [11]
2MeSADP DMGADQ1 Discovery agent N.A. Investigative [17]
2MeSAMP DMBO2DC Discovery agent N.A. Investigative [17]
R-138727 DML49FI Discovery agent N.A. Investigative [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [33]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [27]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD9 antigen (CD9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Panobinostat DM58WKG Chronic graft versus host disease Approved [38]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [42]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [43]
Bortezomib DMNO38U Leukemia Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl-hydrocarbon-interacting protein-like 1 (AIPL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [45]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [46]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [47]
Milchsaure DM462BT Pruritus EC90 Investigative [48]
Drug(s) Affected By Actin-related protein 2/3 complex subunit 1A (ARPC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [42]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [54]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [49]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [55]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
P2Y purinoceptor 12 (P2RY12) TTZ1DT0 P2Y12_HUMAN Antagonist [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin-related protein 2/3 complex subunit 1A (ARPC1A) OTAEEXGQ ARC1A_HUMAN Drug Response [8]
Aryl-hydrocarbon-interacting protein-like 1 (AIPL1) OT4VBD78 AIPL1_HUMAN Drug Response [9]
CD9 antigen (CD9) OT2184XU CD9_HUMAN Drug Response [10]
Putative protein CASTOR3P (GATS) OTDYE3XK CAST3_HUMAN Drug Response [8]
UDP-glucuronosyltransferase 2B7 OT2Q71VQ UD2B7_HUMAN Drug Response [8]

References

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