Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCIGRB)

Drug Name
Fialuridine Drug Info
Synonyms FIAU
Indication
Disease Entry ICD 11 Status REF
Hepatitis B virus infection 1E51.0 Phase 2 [1]
Cross-matching ID
PubChem CID
50313
CAS Number
CAS 69123-98-4
TTD Drug ID
DMCIGRB

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [5]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [6]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [7]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [8]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [9]
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [10]
Famciclovir DMJHLSD Meniere disease AB31.0 Approved [11]
Valacyclovir Hydrochloride DM5I1CE Herpes simplex virus infection 1F00 Approved [6]
Foscavir DM9KJLZ Cytomegalovirus retinitis 9B72.00 Approved [9]
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Drug(s) Affected By Cytochrome b (CYTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [13]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [15]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
Urethane DM7NSI0 N. A. N. A. Phase 4 [17]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [18]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [19]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [20]
Ethidium DMMEQUR Discovery agent N.A. Investigative [21]
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Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [25]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [15]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [25]
Menthol DMG2KW7 Back pain ME84.Z Approved [28]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [29]
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Drug(s) Affected By ATP synthase subunit a (ATP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [15]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [32]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [33]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
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Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 3 (ND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [33]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [19]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [20]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [36]
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Drug(s) Affected By Equilibrative nucleoside transporter 3 (SLC29A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [35]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [4]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [4]
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Drug(s) Affected By Equilibrative nucleoside transporter 1 (SLC29A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [44]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [45]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [39]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [47]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
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Drug(s) Affected By Thymidine kinase 2, mitochondrial (TK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [39]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [15]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [51]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [35]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [52]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [53]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [54]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
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Drug(s) Affected By Ribonucleoside-diphosphate reductase large subunit (RRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [61]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP synthase subunit a (ATP6) OTPHOGLX ATP6_HUMAN Gene/Protein Processing [3]
Cytochrome b (CYTB) OTAHB98A CYB_HUMAN Gene/Protein Processing [3]
Cytochrome c oxidase subunit 2 (COX2) OTTMVBJJ COX2_HUMAN Gene/Protein Processing [3]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Drug Response [3]
Equilibrative nucleoside transporter 3 (SLC29A3) OTGLX8XU S29A3_HUMAN Regulation of Drug Effects [4]
NADH-ubiquinone oxidoreductase chain 3 (ND3) OT1OC3K3 NU3M_HUMAN Gene/Protein Processing [3]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Drug Response [3]
Thymidine kinase 2, mitochondrial (TK2) OTS1V4XB KITM_HUMAN Drug Response [3]

References

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2 Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3592-7.
3 Mechanisms of Chronic Fialuridine Hepatotoxicity as Revealed in Primary Human Hepatocyte Spheroids. Toxicol Sci. 2019 Oct 1;171(2):385-395. doi: 10.1093/toxsci/kfz195.
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8 Extensive oral shedding of human herpesvirus 8 in a renal allograft recipient. Oral Microbiol Immunol. 2009 Apr;24(2):109-15.
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20 Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
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27 Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
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31 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
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52 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
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59 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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