Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME4JGF)

• Drug Name: methyl isocyanate Drug Info
• Synonyms: isocyanatomethane; methyl carbonimide; isocyanic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 12228
  ChEBI ID: CHEMBL59059
  CAS Number: CAS 624-83-9
  TTD Drug ID: DME4JGF

Molecule-Related Drug Atlas

Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[5]
LY3526318	DMFXNQM	Chronic low-back pain	MG30	Phase 2	[6]
HX-100	DMFRM15	Diabetic neuropathy	8C0Z	Phase 1	[7]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[8]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[9]
[3H]resolvin D1	DMFT0HU	Discovery agent	N.A.	Investigative	[10]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[11]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[12]
4-oxo-nonenal	DMPX1J9	Discovery agent	N.A.	Investigative	[13]
dibutyl phthalate	DMEDGKO	Discovery agent	N.A.	Investigative	[14]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[15]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[16]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[21]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[22]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[23]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[24]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[27]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[28]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[31]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[32]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[33]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[34]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transformation-sensitive protein p120 (TRPA1)	TTELV3W	TRPA1_HUMAN	Activator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[3]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Gene/Protein Processing	[4]

References

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