Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHIDCJ)

Drug Name
Octreotide Drug Info
Synonyms
Longastatin; Octreotida; Octreotidum; Sandostatine; Octreotida [Spanish]; Octreotide Acetate Salt; Octreotidum [Latin]; DRG-0115; HS-2020; Octreotide-LAR; SAN 201-995; SM 201-995; SMS 201-995; Sandostatin (TN); Sandoz 201-995; Octreotide (USAN/INN); Octreotide [USAN:INN:BAN]; SMS-201-995; Zacycloicosane-4-carboxamide acetate; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide; L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide; D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide; 10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa;10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide; 10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Indication
Disease Entry ICD 11 Status REF
Acromegaly 5A60.0 Approved [1]
Carcinoid syndrome 5B10 Approved [2]
Diabetic retinopathy 9B71.0 Approved [2]
Neuroendocrine cancer 2B72.1 Investigative [2]
Therapeutic Class
Anabolic Agents
Cross-matching ID
PubChem CID
448601
ChEBI ID
CHEMBL1680
CAS Number
CAS 83150-76-9
TTD Drug ID
DMHIDCJ
VARIDT Drug ID
DR01163

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Somatostatin receptor type 2 (SSTR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pasireotide DMHM7JS Cushing disease 5A70 Approved [9]
Lanreotide acetate DMG6ZU4 Acromegaly 5A60.0 Approved [10]
Ga-68-DOTATOC DMZ0P95 Diagnostic imaging N.A. Approved [11]
Copper dotatate Cu-64 DM26KR1 Diagnostic imaging N.A. Approved [12]
ODT-8 DMBWO5T N. A. N. A. Phase 3 [13]
Paltusotine DM97IN2 Acromegaly 5A60.0 Phase 3 [14]
TBR-760 DMM5BVG Pituitary adenoma 2F37.0 Phase 2 [15]
Re-188-P-2045 DM614BA Lung cancer 2C25.0 Phase 1/2 [16]
PEN-221 DMMAUOK Neuroendocrine cancer 2B72.1 Phase 1/2 [17]
FR-121196 DMNRUGA Alzheimer disease 8A20 Terminated [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Folic Acid DMEMBJC Colorectal carcinoma Approved [21]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [22]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [25]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [26]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [27]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [28]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [29]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [30]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [30]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [31]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [29]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [30]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [32]
Gefitinib DM15F0X Colon adenocarcinoma Approved [29]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [5]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [29]
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Drug(s) Affected By Thyrotropin subunit beta (TSHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [35]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [36]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [37]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [38]
NITRATE DMVFB93 Discovery agent N.A. Investigative [39]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [40]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Epinephrine DM3KJBC Acute asthma CA23 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [47]
Fructose DM43AN2 Vomiting MD90 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [49]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Gefitinib DM15F0X Colon adenocarcinoma Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Epinephrine DM3KJBC Acute asthma CA23 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Fructose DM43AN2 Vomiting MD90 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [56]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [57]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Somatostatin receptor type 2 (SSTR2) TTZ6T9E SSR2_HUMAN Binder [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [5]
Thyrotropin subunit beta (TSHB) OTFDI39D TSHB_HUMAN Protein Interaction/Cellular Processes [6]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Gene/Protein Processing [7]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Gene/Protein Processing [7]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [8]

References

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2 Octreotide FDA Label
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27 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
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42 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
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