Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJWT3X)

Drug Name
HONOKIOL Drug Info
Synonyms
Honokiol; 35354-74-6; 5,3'-Diallyl-2,4'-dihydroxybiphenyl; NSC 293100; Honokiol,(S); UNII-11513CCO0N; 3,5'-Diallyl-4,2'-dihydroxybiphenyl; 3',5-Diallylbiphenyl-2,4'-diol; CPD000387107; CHEMBL16901; CHEBI:5759; 4-allyl-2-(3-allyl-4-hydroxy-phenyl)phenol; 3',5-diallyl-[1,1'-biphenyl]-2,4'-diol; 11513CCO0N; 3',5-diallyl-2,4'-biphenyldiol; AK-25837; 5,3& -Diallyl-2,4& Q-100425; [1,1'-Biphenyl]-2,4'-diol, 3',5-di-2-propenyl-; SMR000387107; 3',5-di(prop-2-en-1-yl)biphenyl-2,4'-diol; houpa
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
72303
ChEBI ID
CHEMBL16901
CAS Number
CAS 35354-74-6
TTD Drug ID
DMJWT3X

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [6]
Naproxen DMZ5RGV Bursitis Approved [7]
Mesalazine DMOL5IU Diverticulitis Approved [8]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [9]
Bromfenac DMKB79O Pain MG30-MG3Z Approved [10]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [11]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [12]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [11]
Suprofen DMKXJZ7 Miosis LA11.62 Approved [13]
Gamma-Homolinolenic acid DMSXKYG Malnutrition 5B50-5B71 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [15]
Naproxen DMZ5RGV Bursitis Approved [7]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [16]
Indomethacin DMSC4A7 Bursitis Approved [11]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [17]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [18]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [19]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [20]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [9]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [11]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting LOX-5 messenger RNA (ALOX5 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TEBUFELONE DMMUE8P Pain MG30-MG3Z Discontinued in Phase 2 [21]
ZD-2138 DMVFCX7 Asthma CA23 Discontinued in Phase 2 [22]
BW A4C DMNUMDG Arthritis FA20 Terminated [23]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [24]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl DMWNJ84 Discovery agent N.A. Investigative [1]
METHYLHONOKIOL DM9YE6K Discovery agent N.A. Investigative [1]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [25]
PUUPEHENONE DMF3BCK Discovery agent N.A. Investigative [25]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [25]
5,3'-Dipropyl-biphenyl-2,4'-diol DMJRXLD Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [27]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [28]
Panobinostat DM58WKG Chronic graft versus host disease Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Testosterone DM7HUNW Hot flushes GA30 Approved [31]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [31]
Leflunomide DMR8ONJ Arthritis FA20 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [39]
Leflunomide DMR8ONJ Arthritis FA20 Approved [32]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [40]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Gefitinib DM15F0X Colon adenocarcinoma Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [48]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
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Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [55]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [58]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [59]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [64]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [65]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [66]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [65]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [71]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [72]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [76]
Panobinostat DM58WKG Chronic graft versus host disease Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain-2 catalytic subunit (CAPN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [82]
Testosterone DM7HUNW Hot flushes GA30 Approved [31]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [80]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [31]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [88]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [90]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [91]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [93]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [94]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [97]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [101]
Selenium DM25CGV N. A. N. A. Approved [102]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [103]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [104]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [105]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [108]
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Drug(s) Affected By DNA polymerase lambda (POLL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [102]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [109]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [110]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [111]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [112]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [113]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [114]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
LOX-5 messenger RNA (ALOX5 mRNA) TTSJ6Q4 LOX5_HUMAN Inhibitor [1]
Prostaglandin G/H synthase 1 (COX-1) TT8NGED PGH1_HUMAN Inhibitor [1]
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [2]
Calpain-2 catalytic subunit (CAPN2) OTIAPE5J CAN2_HUMAN Gene/Protein Processing [2]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [2]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [2]
DNA polymerase lambda (POLL) OTZ24QGM DPOLL_HUMAN Gene/Protein Processing [3]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Gene/Protein Processing [2]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [4]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [5]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Gene/Protein Processing [2]
Twist-related protein 1 OTB3H60O TWST1_HUMAN Gene/Protein Processing [2]

References

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57 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
58 Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
59 Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
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61 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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