Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKQTBA)

Drug Name
Diphenhydramine Drug Info
Synonyms
diphenhydramine; 58-73-1; Benadryl; Benzhydramine; Probedryl; Alledryl; Antistominum; Dihidral; 2-(Benzhydryloxy)-N,N-dimethylethanamine; Benzhydraminum; Benzhydroamina; Diphantine; Difenhydramin; Ibiodral; Difedryl; Dibondrin; Mephadryl; Desentol; Dermistina; Betramin; Benzhydril; Benzantine; Benachlor; Bagodryl; Syntedril; Novamina; Medidryl; Hyadrine; Histaxin; Etanautine; Drylistan; Diabylen; Diabenyl; Dermodrin; Benodine; Baramine; Allergical; Debendrin; Benadrin; Dabylen; Antomin; Nausen; Benapon; Dylamon; Benylin; Benylan; Benodin; Amidryl; Aleryl; Allerdryl; Allergeval; Allergina; Allergival; Antitussive; Automin; Banophen; Beldin; Belix; Bena; Benhydramin; Benzhydryl; Compoz; Dibendrin; Dibenil; Difenhidramina; Difenidramina; Dimedrol; Dimedryl; Dimehydrinate; Diphen; Diphenhist; Diphenhydraminum; Diphenylhydramin; Diphenylhydramine; Dryistan; Genahist; Hydramine; Hyrexin; Restamin; Rigidil; Siladryl; Silphen; Syntodril; Allergan B; Allermax Caplets; BENADRYL HCl; Banophen Caplets; Benadryl Allergy; Difenidramina [Italian]; Dimedrol base; Diphen Cough; Diphenhist Captabs; Diphenhydramine Base; Diphenhydramine HCl; Nytol Quickcaps; Nytol Quickgels;Twilite Caplets; Unisom Sleepgels Maximum Strength; Dormarex 2; FAR 90X2; PM 255; S51; Aller-Med; Ben-allergin; Benadryl (TN); Benadryl (hydrochloride); Beta-Dimethylaminoethanol diphenylmethyl ether; Beta-Dimethylaminoethylbenzhydrylether; Beta-dimethylaminoethyl benzhydryl ether; Difenhidramina [INN-Spanish]; Dimedrol (TN); Diphenhydraminum [INN-Latin]; Nervine Nighttime Sleep-Aid; Nytol (TN); O-Benzhydryldimethylaminoethanol; Restamin (TN); Sleep-Eze D; Sleep-Eze D Extra Strength; DIPHENHYDRAMINE, ANTISTOMINUM, BENZHYDRAMINE; Diphenhydramine (JP15/INN); Diphenhydramine [INN:BAN:JAN]; Alpha-(2-Dimethylaminoethoxy)diphenylmethane; N-(Benzhydryloksy-etylo)dwumetyloamina; N-(Benzhydryloksy-etylo)dwumetyloamina [Polish]; Beta-Dimethylamino-aethyl-benzhydryl-aether; Beta-Dimethylamino-aethyl-benzhydryl-aether [German]; N,N-Dimethyl-2-(diphenylmethoxy)-ethylamine hydrochloride; N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE; N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine; 2-(Benzhydryloxy)-N,N-dimethylethylamine; 2-(Benzhydryloxy)-N,N-dimethylethylamine, hydrochloride; 2-(Diphenylmethoxy)-N,N-dimethylethylamine; 2-(diphenylmethoxy)-N,N-dimethylethanamine; 2-Diphenylmethoxy-N,N-dimethylethylamine; 2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine; 2-benzhydryloxy-N,N-dimethylethanamine; 2-benzhydryloxyethyl-N,N-dimethylammonium; 2-diphenylmethoxy-N,N-demthylethanamine; 2PM
Indication
Disease Entry ICD 11 Status REF
Hyperemesis gravidarum Approved [1]
Insomnia 7A00-7A0Z Approved [1]
Meniere disease AB31.0 Approved [2]
Nausea MD90 Approved [1]
Seasonal allergic rhinitis CA08.01 Approved [1]
Vasomotor/allergic rhinitis CA08 Approved [1]
Vomiting MD90 Approved [1]
Therapeutic Class
Antiallergic Agents
Cross-matching ID
PubChem CID
3100
ChEBI ID
CHEMBL657
CAS Number
CAS 58-73-1
TTD Drug ID
DMKQTBA
VARIDT Drug ID
DR00385
INTEDE Drug ID
DR0514
ACDINA Drug ID
D00203

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine N-methyltransferase (HNMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [10]
Metoprine DM5GQD7 Advanced cancer 2A00-2F9Z Phase 2 [4]
(L-)-S-adenosyl-L-homocysteine DMDUN83 Discovery agent N.A. Investigative [11]
4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE DM68S9F Discovery agent N.A. Investigative [4]
Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [12]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [13]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [3]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [14]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [15]
Doxepin DMPI98T Anxiety Approved [16]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [3]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [17]
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [18]
Tranilast DME5Y64 Allergic rhinitis CA08.0 Approved [19]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [21]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [7]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [24]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [25]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [26]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [27]
Propranolol DM79NTF Angina pectoris BA40 Approved [28]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [32]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [35]
Estrone DM5T6US Acne vulgaris ED80 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [38]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [40]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [32]
Verapamil DMA7PEW Angina pectoris BA40 Approved [41]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [43]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [44]
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Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [7]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [7]
Diazepam DM08E9O Alcohol withdrawal Approved [7]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [7]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [7]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [7]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [7]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [7]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [7]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [8]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [8]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [8]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [8]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [8]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [8]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [8]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [8]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [53]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [56]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [60]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [8]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [67]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [68]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [65]
Ethacrynic acid DM60QMR Edema MG29 Approved [69]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Antagonist [3]
Histamine N-methyltransferase (HNMT) TT2B6EV HNMT_HUMAN Inhibitor [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [5]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [6]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [7]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [8]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [8]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Gene/Protein Processing [9]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Gene/Protein Processing [8]

References

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