Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKV32D)

• Drug Name: Xylometazoline Drug Info
• Synonyms: Xylometazoline (nasal mucoadhesive/MucoAd, congestion); Decongestant (nasal mucoadhesive/MucoAd, congestion), Strategic BioSciences; Xylometazoline (nasal mucoadhesive/MucoAd, congestion), Strategic BioSciences

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Phase 4	[1]

• Cross-matching ID:
  PubChem CID: 5709
  ChEBI ID: CHEBI:10082
  CAS Number: CAS 526-36-3
  TTD Drug ID: DMKV32D

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-2C (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[3]
Dihydroergocristine	DM5SQ1G	Alcohol dependence	6C40.2	Approved	[4]
Brimonidine	DMQLT4N	Ocular hypertension	9C61.01	Approved	[5]
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[6]
Amezinium	DM6I2WQ	Hypotension	BA20-BA21	Approved	[7]
Propylhexedrine	DMTBW2O	Obesity	5B81	Approved	[8]
Tetrahydrozoline	DMT57WC	Ocular disease	1F00.1Z	Approved	[9]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[10]
TNX-102	DMO1234	Fibromyalgia	MG30.01	Phase 3	[11]
IDAZOXAN HYDROCHLORIDE	DMSP0X8	Neurological disorder	6B60	Phase 3	[12]

Drug(s) Affected By Alpha-2C adrenergic receptor (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[2]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[19]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[20]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[21]

Drug(s) Affected By Alpha-2A adrenergic receptor (ADRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[23]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[2]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Indapamide	DMGN1PW	Edema	MG29	Approved	[29]

Drug(s) Affected By Alpha-1D adrenergic receptor (ADRA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alfuzosin	DMZVMKF	Benign prostatic hyperplasia	GA90	Approved	[30]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[32]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Terbutaline	DMD4381	Asthma	CA23	Approved	[34]
Methoxamine	DMF5XQH	Hypertension	BA00-BA04	Approved	[33]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[34]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[33]

Drug(s) Affected By Alpha-1A adrenergic receptor (ADRA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamsulosin	DM5QF9V	Benign prostatic hyperplasia	GA90	Approved	[35]
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[32]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[23]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[31]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[30]

Drug(s) Affected By Alpha-1B adrenergic receptor (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[2]
Terbutaline	DMD4381	Asthma	CA23	Approved	[34]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alpha-1A adrenergic receptor (ADRA1A)	OTUIWCL5	ADA1A_HUMAN	Protein Interaction/Cellular Processes	[2]
Alpha-1B adrenergic receptor (ADRA1B)	OTSAYAFD	ADA1B_HUMAN	Protein Interaction/Cellular Processes	[2]
Alpha-1D adrenergic receptor (ADRA1D)	OTW2CD1O	ADA1D_HUMAN	Protein Interaction/Cellular Processes	[2]
Alpha-2A adrenergic receptor (ADRA2A)	OTZFGOTP	ADA2A_HUMAN	Protein Interaction/Cellular Processes	[2]
Alpha-2C adrenergic receptor (ADRA2C)	OT5B9RKP	ADA2C_HUMAN	Protein Interaction/Cellular Processes	[2]

References

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