Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM10TG)

Drug Name

Cirsimarin Drug Info

Synonyms

Cirsimarin; Cirsitakaoside; 13020-19-4; CHEMBL517637; 2-(4-(beta-D-Glucopyranosyloxy)phenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2-(4-(beta-D-glucopyranosyloxy)phenyl)-5-hydroxy-6,7-dimethoxy-; AC1L4LVL; AC1Q6CLV; SCHEMBL2016369; MolPort-019-937-034; BDBM50250467; ZINC31459932; MCULE-1339456605; 4-(5-hydroxy-6,7-dimethoxy-4-oxo-4h-chromen-2-yl)phenyl; LS-39681

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 159460
ChEBI ID: CHEMBL517637
CAS Number: CAS 13020-19-4
TTD Drug ID: DMM10TG

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Adenosine A1 receptor (ADORA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[3]
Rolofylline	DMSZPR3	Heart failure	BD10-BD13	Phase 3	[4]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[5]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[6]
SELODENOSON	DMQM3IX	Cardiac arrhythmias	BC9Z	Phase 2	[7]
Apaxifylline	DMQMV9F	Cognitive impairment	6D71	Phase 2	[8]
SLV320	DM867BJ	Heart failure	BD10-BD13	Phase 2	[9]
DTI-0009	DMV84OK	Atrial fibrillation	BC81.3	Phase 2	[7]
Capadenoson	DMYWO62	Atrial fibrillation	BC81.3	Phase 2	[10]
BAY 1067197	DM4JGNH	Heart failure	BD10-BD13	Phase 2	[11]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[12]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[15]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[16]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[18]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[21]
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Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[24]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[25]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[31]
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Drug(s) Affected By Stromelysin-3 (MMP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[37]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[40]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[15]
Selenium	DM25CGV	N. A.	N. A.	Approved	[43]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[46]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[49]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A1 receptor (ADORA1)	TTK25J1	AA1R_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[2]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[2]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[2]
Stromelysin-3 (MMP11)	OTRTXDBM	MMP11_HUMAN	Gene/Protein Processing	[2]

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