Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMIHVP)

• Drug Name: Dextroamphetamine Drug Info
• Synonyms: D-Amphetamine; dextroamphetamine; Dexamphetamine; Dexamfetamine; (S)-Amphetamine; Dexadrine; (+)-(S)-Amphetamine; Dexedrine; (2S)-1-phenylpropan-2-amine; (S)-(+)-Amphetamine; Dextrostat; Desamfetamina; (S)-1-Phenyl-2-propylamine; Dexidrine; Sympamin; Dephadren; Amsustain; (+)-Phenaminum; (+)-alpha-Methylphenethylamine; (S)-1-Phenyl-2-aminopropane; (+)-alpha-Methylphenylethylamine; D-(S)-Amphetamine; (S)-(+)-beta-Phenylisopropylamine; 51-64-9; (S)-alpha-Phenylethylamine; (2S)-(+)-Amphetamine; Benzedrine; Dexacaps; Dexamfetamina; Dexamfetaminum; Dexamphetaminum; Dexanfetamina; Isoamycin; Propisamine; Psychedrine; Raphetamine; Rhinalator; Simpatedrin; Sympamine; Sympatedrine; Weckamine; Desamfetamina [DCIT]; Dexedrine Spansule; Dextroamphetamine [USAN]; Dextroamphetamine resin complex; D-AM; Dexamfetamina [INN-Spanish]; Dexamfetamine (INN); Dexamfetaminum [INN-Latin]; Dexamphetaminum [INN-Latin]; Dexanfetamina [INN-Spanish]; Dexedrine (TN); Dextro-Amphetamine; Dextro-Amphetamine Sulfate; Dextroamphetamine (USAN); Dextrostat (TN); Dl-Amphetamine; Dl-Benzedrine; Fenylo-izopropylaminyl; Beta-phenyl-isopropylamine; D-alpha-methylphenethylamine; Alpha-Methylphenethylamine, d-form; S(+)-Amphetamine; D-(+)-Amphetamine; D-1-Phenyl-2-aminopropan; D-1-Phenyl-2-aminopropan [German]; D-1-Phenyl-2-aminopropane; D-2-Amino-1-phenylpropane; Dl-1-Phenyl-2-aminopropane; Benzeneethanamine, alpha-methyl-, (aS)-(9CI); Phenethylamine, alpha-methyl-, (+)-(8CI); (+/-)-Benzedrine; (+/-)-Desoxynorephedrine; (+/-)-beta-Phenylisopropylamine; (S)-1-Phenyl-2-propanamine; (S)-alpha-Methylphenethylamine; (S)-alpha-methylbenzeneethanamine; (alphaS)-alpha-methylbenzeneethanamine; dextroamphetamine sulfate (oral liquid, ADHD), Auriga

Indication

Disease Entry	ICD 11	Status	REF
Attention deficit hyperactivity disorder	6A05.Z	Approved	[1]
Depression	6A70-6A7Z	Approved	[2]
Narcolepsy	7A20	Approved	[1]

• Therapeutic Class: Central Nervous System Stimulants
• Cross-matching ID:
  PubChem CID: 5826
  ChEBI ID: CHEBI:4469
  CAS Number: CAS 51-64-9
  TTD Drug ID: DMMIHVP
  VARIDT Drug ID: DR00675
  INTEDE Drug ID: DR1759
  ACDINA Drug ID: D00189

Molecule-Related Drug Atlas

Drug(s) Targeting Trace amine-associated receptor-1 (TAAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[3]
Lisdexamfetamine	DM6W8V5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[9]
Hydroxyamphetamine Hydrobromide	DMQSGM0	Horner syndrome	8D8A.1	Approved	[10]
SEP-363856	DMG2QP4	Schizophrenia	6A20	Phase 3	[11]
NT0202	DMCMIJ1	Attention deficit hyperactivity disorder	6A05.Z	Phase 3	[3]
SPD-465	DM7NV1I	Attention deficit hyperactivity disorder	6A05.Z	Phase 3	[3]
RG-7351	DMFGR98	Major depressive disorder	6A70.3	Phase 1	[12]
tyramine	DM4UXT1	Discovery agent	N.A.	Investigative	[13]
EPPTB	DMK3VID	Discovery agent	N.A.	Investigative	[14]
R(-)amphetamine	DM72ES1	Discovery agent	N.A.	Investigative	[15]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[17]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[21]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[22]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[23]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[24]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[25]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[30]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[36]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[39]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[42]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[43]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[44]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[45]

Drug(s) Affected By Sodium-dependent noradrenaline transporter (SLC6A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[46]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[46]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[51]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[52]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[62]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Sodium-dependent dopamine transporter (SLC6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[65]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[66]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[67]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[71]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[72]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Affected By Synaptic vesicular amine transporter (SLC18A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[74]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[74]
Methamphetamine	DMPM4SK	Anxiety		Approved	[75]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[76]
Haloperidol	DM96SE0	Delirium		Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[36]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[42]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[82]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[83]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[86]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[87]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[92]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[100]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[101]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[105]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[107]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[109]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[34]

Drug(s) Affected By Disrupted in schizophrenia 1 protein (DISC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[32]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[112]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[112]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[113]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[114]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[117]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[118]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[121]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]

Drug(s) Affected By Glial cell line-derived neurotrophic factor (GDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[129]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[125]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[131]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[137]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[140]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[140]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[140]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[141]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[140]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Trace amine-associated receptor-1 (TAAR1)	TTIU98M	TAAR1_HUMAN	Modulator	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6) Main DME	DECB0K3	CP2D6_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[5]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[5]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[5]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[5]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[5]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Gene/Protein Processing	[5]
Brain-derived neurotrophic factor (BDNF)	OTLGH7EW	BDNF_HUMAN	Drug Response	[6]
Catechol O-methyltransferase (COMT)	OTPWKTQG	COMT_HUMAN	Drug Response	[7]
Disrupted in schizophrenia 1 protein (DISC1)	OT43AW4H	DISC1_HUMAN	Drug Response	[8]

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