Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPN1TW)

Drug Name
Dofetilide Drug Info
Synonyms
Dofetilida; Dofetilidum; Tikosyn; Xelide; UK 68798; Dofetilida [INN-Spanish]; Dofetilidum [INN-Latin];Tikosyn (TN); UK 68,798; UK-68798; Dofetilide [USAN:BAN:INN]; Tikosyn, UK68798, Dofetilide; UK-68,798; Dofetilide (JAN/USAN/INN); Beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide; N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide; N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide; Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl); 1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane; 1-MSPMPE
Indication
Disease Entry ICD 11 Status REF
Sinus rhythm disorder BC9Y Approved [1]
Therapeutic Class
Antiarrhythmic Agents
Cross-matching ID
PubChem CID
71329
ChEBI ID
CHEBI:4681
CAS Number
CAS 115256-11-6
TTD Drug ID
DMPN1TW
VARIDT Drug ID
DR00724
INTEDE Drug ID
DR0522
ACDINA Drug ID
D00208

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Potassium channel unspecific (KC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [2]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [2]
Dronedarone DMA8FS5 Angina pectoris BA40 Approved [7]
Amifampridine DMK08L3 LambertEaton myasthenic syndrome 8C62 Approved [8]
Minoxidil DMA2Z4F Alopecia ED70 Approved [2]
Pinacidil DMRADYL High blood pressure BA00 Approved [2]
Dalfampridine DMM0PDO Multiple sclerosis 8A40 Approved [9]
Ibutilide DMKXY2R Atrial fibrillation BC81.3 Approved [2]
Diazoxide DML1538 Congenital hyperinsulinism 5A4Y Approved [2]
Azimilide DMUIBV8 Atrial fibrillation BC81.3 Phase 3 [10]
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Drug(s) Transported By Organic cation transporter 2 (SLC22A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [11]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [12]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [13]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [14]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [15]
Propranolol DM79NTF Angina pectoris BA40 Approved [16]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [17]
Metformin DM89QE1 Colorectal carcinoma Approved [18]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [16]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [19]
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Drug(s) Transported By Multidrug and toxin extrusion protein 1 (SLC47A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [20]
Metformin DM89QE1 Colorectal carcinoma Approved [21]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [20]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [20]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [22]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [20]
Topotecan DMP6G8T Central nervous system neoplasm Approved [20]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [23]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [24]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [25]
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Drug(s) Transported By Multidrug and toxin extrusion protein 2 (SLC47A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [20]
Metformin DM89QE1 Colorectal carcinoma Approved [20]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [20]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [20]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [20]
Topotecan DMP6G8T Central nervous system neoplasm Approved [20]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [24]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [20]
N-methylpyridinium DMVUKEW N. A. N. A. Preclinical [20]
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [20]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [33]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [27]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [35]
Quinidine DMLPICK N. A. N. A. Approved [36]
Verapamil DMA7PEW Angina pectoris BA40 Approved [37]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [38]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [38]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [39]
Propranolol DM79NTF Angina pectoris BA40 Approved [40]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [41]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [38]
Cisapride DMY7PED Gastroesophageal reflux disease DA22.Z Approved [42]
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Drug(s) Affected By Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [43]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [43]
Quinidine DMLPICK N. A. N. A. Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [45]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Mepivacaine DMH2NMY Analgesia MB40.8 Approved [45]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [48]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [48]
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Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [5]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [49]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Meloxicam DM2AR7L Arthritis FA20 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [54]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Retigabine DMGNYIH Behcet disease 4A62 Approved [57]
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Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [59]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [60]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [62]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [63]
Capsaicin DMGMF6V Back pain ME84.Z Approved [64]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [65]
Quinidine DMLPICK N. A. N. A. Approved [66]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [67]
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Drug(s) Affected By Potassium voltage-gated channel subfamily E member 1 (KCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [69]
Pentobarbital DMFNH7L Brain ischaemia 8B1Z Approved [70]
Verapamil DMA7PEW Angina pectoris BA40 Approved [5]
Propranolol DM79NTF Angina pectoris BA40 Approved [5]
Diltiazem DMAI7ZV Angina pectoris BA40 Approved [5]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [5]
Quinidine DMLPICK N. A. N. A. Approved [5]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [5]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Potassium channel unspecific (KC) TT1VOHK NOUNIPROTAC Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug and toxin extrusion protein 2 (SLC47A2) DT3TX4H S47A2_HUMAN Substrate [3]
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [3]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Drug Response [5]
Potassium voltage-gated channel subfamily E member 1 (KCNE1) OTZNQUW9 KCNE1_HUMAN Drug Response [5]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [6]
Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1) OT8SPJNX KCNQ1_HUMAN Drug Response [5]
Sodium channel protein type 5 subunit alpha (SCN5A) OTGYZWR6 SCN5A_HUMAN Drug Response [5]

References

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3 FDA Drug Development and Drug Interactions
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