General Information of Drug (ID: DMR90HY)

Drug Name
Deoxythymidine Drug Info
Synonyms
Thymidine; thymidine; 50-89-5; deoxythymidine; 2'-Deoxythymidine; Beta-Thymidine; 5-Methyldeoxyuridine; Thymidin; DThyd; 5-Methyl-2'-deoxyuridine; Thymine-2-deoxyriboside; Thyminedeoxyriboside; Thymine-2-desoxyriboside; 5-Methyldeoxyurindine; dThd; Uridine, 2'-deoxy-5-methyl-; Thymine deoxyriboside; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; dT; UNII-VC2W18DGKR; Deoxyribothymidine; AI3-52267; 2'-thymidine; beta-D-Ribofuranoside, thymine-1 2-deoxy-; CCRIS 1283; CHEBI:17748
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5789
ChEBI ID
CHEBI:17748
CAS Number
CAS 146183-25-7
TTD Drug ID
DMR90HY
INTEDE Drug ID
DR1586

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting Thymidine kinase 1 (TK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [1]
DEOXYCYTIDINE DMYE5LJ Acute myeloid leukaemia 2A60 Approved [11]
TK-DLI DM26I8H Graft-versus-host disease 4B24 Preregistration [12]
FV-100 DMZARP1 Varicella zoster virus infection 1E91 Phase 3 [13]
Radiosensitizer gene therapy DMN1ZEU Pancreatic cancer 2C10 Phase 3 [14]
RP101 DMNIYSZ Infectious disease 1A00-CA43.1 Phase 2/3 [15]
HQK-1004 DM3WX0K Solid tumour/cancer 2A00-2F9Z Phase 2 [16]
Rilapladib DMB9861 Arteriosclerosis BD40 Phase 1 [17]
Ad-OC-hsvTK/valacyclovir DM9GLHO Prostate cancer 2C82.0 Phase 1 [18]
Thymidine kinase-expressing adenovirus and ganciclovir suicide gene therapy DMO8SGD Solid tumour/cancer 2A00-2F9Z Phase 1 [19]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetate Ion DMD08RH Discovery agent N.A. Investigative [1]
AMP-PNP DMTOK1D Discovery agent N.A. Investigative [20]
2'-deoxythymidine triphosphate DM9OEJT Discovery agent N.A. Investigative [1]
Diphosphate DMHY30B Discovery agent N.A. Investigative [1]
Thymidine-5'-Phosphate DMKM6NQ Discovery agent N.A. Investigative [1]
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate DMM4VWD Discovery agent N.A. Investigative [15]
3'-Azido-3'-Deoxythymidine-5'-Monophosphate DMU08MN Discovery agent N.A. Investigative [1]
5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate DMWVCJ1 Discovery agent N.A. Investigative [1]
CHLORODEOXYURIDINE DMQT3WJ Discovery agent N.A. Investigative [21]
BROMODEOXYURIDINE DM0D7LA Discovery agent N.A. Investigative [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Thymidine phosphorylase (TYMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [22]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [23]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [24]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [25]
Drug(s) Affected By Uteroglobin (SCGB1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [27]
Arsenic DMTL2Y1 N. A. N. A. Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [29]
paraquat DMR8O3X Discovery agent N.A. Investigative [30]
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [33]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [34]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [38]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Gefitinib DM15F0X Colon adenocarcinoma Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Epinephrine DM3KJBC Acute asthma CA23 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [46]
Fructose DM43AN2 Vomiting MD90 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [49]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Panobinostat DM58WKG Chronic graft versus host disease Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [56]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [57]
Testosterone DM7HUNW Hot flushes GA30 Approved [58]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [59]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [9]
Selenium DM25CGV N. A. N. A. Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [64]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [65]
Testosterone DM7HUNW Hot flushes GA30 Approved [58]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [66]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fomepizole DM6VOWQ Athylene glycol or methanol poisoning NE61 Approved [67]
Ademetionine DMYQDBO Hepatic fibrosis DB93.0 Approved [68]
Theophylline DMRJFN9 Bronchitis CA20 Approved [69]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [70]
Ethanol DMDRQZU Chronic pain MG30 Approved [71]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [72]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [74]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [69]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [82]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [57]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Testosterone DM7HUNW Hot flushes GA30 Approved [88]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [92]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [93]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [94]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [96]
Arsenic DMTL2Y1 N. A. N. A. Approved [97]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [72]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [98]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
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Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [101]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [107]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [108]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [109]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mycobacterium Thymidine monophosphate kinase (MycB tmk) TT5B8AX KTHY_MYCTU Inhibitor [1]
Thymidine kinase 1 (TK1) TTP3QRF KITH_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Thymidine phosphorylase (TYMP) Main DME DE4HCYL TYPH_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Drug Response [5]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Regulation of Drug Effects [6]
Glutathione S-transferase theta-1 (GSTT1) OTRFMWBK GSTT1_HUMAN Drug Response [7]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Regulation of Drug Effects [8]
Macrophage colony-stimulating factor 1 (CSF1) OT68M7RD CSF1_HUMAN Regulation of Drug Effects [9]
Maleylacetoacetate isomerase (GSTZ1) OTQ43JCE MAAI_HUMAN Drug Response [7]
Thymidine phosphorylase OT6BQTMR TYPH_HUMAN Biotransformations [10]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Gene/Protein Processing [4]

References

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57 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
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61 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
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66 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
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70 Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
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