Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR90HY)

Drug Name
Deoxythymidine Drug Info
Synonyms
Thymidine; thymidine; 50-89-5; deoxythymidine; 2'-Deoxythymidine; Beta-Thymidine; 5-Methyldeoxyuridine; Thymidin; DThyd; 5-Methyl-2'-deoxyuridine; Thymine-2-deoxyriboside; Thyminedeoxyriboside; Thymine-2-desoxyriboside; 5-Methyldeoxyurindine; dThd; Uridine, 2'-deoxy-5-methyl-; Thymine deoxyriboside; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; dT; UNII-VC2W18DGKR; Deoxyribothymidine; AI3-52267; 2'-thymidine; beta-D-Ribofuranoside, thymine-1 2-deoxy-; CCRIS 1283; CHEBI:17748
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5789
ChEBI ID
CHEMBL52609
CAS Number
CAS 146183-25-7
TTD Drug ID
DMR90HY
INTEDE Drug ID
DR1586

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Thymidine kinase 1 (TK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [1]
DEOXYCYTIDINE DMYE5LJ Acute myeloid leukaemia 2A60 Approved [7]
TK-DLI DM26I8H Graft-versus-host disease 4B24 Preregistration [8]
FV-100 DMZARP1 Varicella zoster virus infection 1E91 Phase 3 [9]
Radiosensitizer gene therapy DMN1ZEU Pancreatic cancer 2C10 Phase 3 [10]
RP101 DMNIYSZ Infectious disease 1A00-CA43.1 Phase 2/3 [11]
HQK-1004 DM3WX0K Solid tumour/cancer 2A00-2F9Z Phase 2 [12]
Rilapladib DMB9861 Arteriosclerosis BD40 Phase 1 [13]
Ad-OC-hsvTK/valacyclovir DM9GLHO Prostate cancer 2C82.0 Phase 1 [14]
Thymidine kinase-expressing adenovirus and ganciclovir suicide gene therapy DMO8SGD Solid tumour/cancer 2A00-2F9Z Phase 1 [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Mycobacterium Thymidine monophosphate kinase (MycB tmk)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetate Ion DMD08RH Discovery agent N.A. Investigative [1]
AMP-PNP DMTOK1D Discovery agent N.A. Investigative [16]
2'-deoxythymidine triphosphate DM9OEJT Discovery agent N.A. Investigative [1]
Diphosphate DMHY30B Discovery agent N.A. Investigative [1]
Thymidine-5'-Phosphate DMKM6NQ Discovery agent N.A. Investigative [1]
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate DMM4VWD Discovery agent N.A. Investigative [11]
3'-Azido-3'-Deoxythymidine-5'-Monophosphate DMU08MN Discovery agent N.A. Investigative [1]
5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate DMWVCJ1 Discovery agent N.A. Investigative [1]
CHLORODEOXYURIDINE DMQT3WJ Discovery agent N.A. Investigative [17]
BROMODEOXYURIDINE DM0D7LA Discovery agent N.A. Investigative [17]
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Drug(s) Metabolized By Thymidine phosphorylase (TYMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [19]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [20]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [21]
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [22]
Gefitinib DM15F0X Colon adenocarcinoma Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Epinephrine DM3KJBC Acute asthma CA23 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [27]
Fructose DM43AN2 Vomiting MD90 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [31]
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Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Panobinostat DM58WKG Chronic graft versus host disease Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [37]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [38]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [40]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
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Drug(s) Affected By Maleylacetoacetate isomerase (GSTZ1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Testosterone DM7HUNW Hot flushes GA30 Approved [45]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [49]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [50]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mycobacterium Thymidine monophosphate kinase (MycB tmk) TT5B8AX KTHY_MYCTU Inhibitor [1]
Thymidine kinase 1 (TK1) TTP3QRF KITH_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Thymidine phosphorylase (TYMP) Main DME DE4HCYL TYPH_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [3]
Maleylacetoacetate isomerase (GSTZ1) OTQ43JCE MAAI_HUMAN Drug Response [4]
Thymidine phosphorylase OT6BQTMR TYPH_HUMAN Biotransformations [5]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Gene/Protein Processing [6]

References

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21 Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm. 2008 Sep-Oct;5(5):717-27.
22 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
23 The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
24 NF-B potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15;6(2):e16815. doi: 10.1371/journal.pone.0016815.
25 Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
26 Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep. 2011 Feb;25(2):583-91. doi: 10.3892/or.2010.1097. Epub 2010 Dec 10.
27 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
28 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
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31 Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
32 Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
33 Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-/Smad signaling pathways. Cell Biol Toxicol. 2021 Jun;37(3):479-496. doi: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17.
34 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
35 Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis. PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.
36 Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway. J Cell Physiol. 2019 Mar;234(3):2606-2617. doi: 10.1002/jcp.27073. Epub 2018 Oct 14.
37 Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. doi: 10.1124/jpet.114.213520. Epub 2014 Apr 4.
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41 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
42 Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
43 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
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