Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRZAQW)

Drug Name
PAF Drug Info
Synonyms
Platelet activating factor; PAF (C16); Platelet-activating factor; 74389-68-7; C16-PAF; 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine; Hag-PC; APRL; Hexadecyl-paf-acether; Platelet-activating factor C16; 1-O-Hexadecyl-platelet-activating factor; PAF C-16; 1-O-Hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine; 1-O-Hexadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine; 1-Hexadecyl-2-acetyl-glycero-3-phosphocholine; C16-PAF acether; 1-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine; Blood platelet-activating factor; platelet activating factor; [3H]PAF
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
108156
ChEBI ID
CHEMBL1235246
CAS Number
CAS 74389-68-7
TTD Drug ID
DMRZAQW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Platelet-activating factor receptor (PTAFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [5]
RUPATADINE DMBPN7T N. A. N. A. Phase 4 [6]
ISRAPAFANT DMP61YB Asthma CA23 Phase 3 [7]
CMI-392 DM1NCUY Psoriasis vulgaris EA90 Phase 2 [8]
Lexipafant DMZ2YBE Nerve injury ND56.4 Phase 2 [9]
YM-264 DMAZNVX Sepsis 1G40-1G41 Phase 2 [10]
Dersalazine DMH96JW Inflammatory bowel disease DD72 Phase 2 [11]
60P002 DMHBN8X Dengue 1D20-1D2Z Phase 2 [12]
PegCNTF DMW7VGZ Obesity 5B81 Phase 1 [13]
FOROPAFANT DML1DGP Asthma CA23 Discontinued in Phase 3 [14]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [15]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [16]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [19]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [20]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [21]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [22]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [23]
Testosterone DM7HUNW Hot flushes GA30 Approved [24]
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Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [27]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [28]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [29]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [26]
Bortezomib DMNO38U Leukemia Approved [30]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [26]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [26]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [31]
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Drug(s) Affected By Collagenase 3 (MMP13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [32]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [33]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [32]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [34]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [35]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Doxycycline DM7ICNU Acne vulgaris ED80 Approved [33]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [38]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
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Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [28]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [42]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [43]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [44]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [40]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [40]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [45]
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Drug(s) Affected By Metalloproteinase inhibitor 4 (TIMP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Isoproterenol DMK7MEY Atrioventricular block Approved [48]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [49]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [50]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [51]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [52]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [55]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [56]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [59]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [64]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [62]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [69]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [70]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [72]
Quercetin DM3NC4M Obesity 5B81 Approved [73]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Platelet-activating factor receptor (PTAFR) TTQL5VC PTAFR_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Protein Interaction/Cellular Processes [3]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [4]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Gene/Protein Processing [4]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Protein Interaction/Cellular Processes [3]
Metalloproteinase inhibitor 4 (TIMP4) OT8A68SW TIMP4_HUMAN Gene/Protein Processing [4]
Oxidized low-density lipoprotein receptor 1 (OLR1) OTS44RIC OLR1_HUMAN Gene/Protein Processing [4]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) OTFL5KR5 LOX12_HUMAN Gene/Protein Processing [4]

References

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