Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS3YE9)

Drug Name
Amantadine Drug Info
Synonyms
Adamantamine; Adamantanamine; Adamantylamine; Amant; Amantadina; Amantadinum; Amantidine; Aminoadamantane; Endantadine; Mantadine; Symadine; Wiregyt; Amantadine Base; BIA4304; OR14310; Amantadina [INN-Spanish]; Amantadine (INN); Amantadine [INN:BAN]; Amantadinum [INN-Latin]; Gen-Amantadine; Pk-merz; Symmetrel (TN); TCMDC-125869; ADAMANTANE,1-AMINO; Adamantan-1-amine; Adamantan-1-ylamine; Tricyclo[3.3.1.1^3,7]decan-1-amine; Tricyclo(3.3.1.13,7)decan-1-amine; Tricyclo[3.3.1.1(3,7)]decan-1-amine; Tricyclo[3.3.1.1(3,7)]decan-1-ylamine; Tricyclo[3.3.1.1(3,7)]decane-1-amine; Tricyclo[3.3.1.1(sup3,7)]decan-1-amine; Tricyclo(3.3.1.1(sup 3,7))decan-1-amine; Tricyclo(3.3.1.1(sup 3.7))decan-1-amine; Tricyclo[3.3.1.1~3,7~]decan-1-amine; Tricyclo(3.3.1.1(3,7))-decan-1-amine; 1-Adamantamine; 1-Adamantanamine; 1-Adamantanamine (8CI); 1-Adamantylamine; 1-Aminoadamantane; 1-Aminotricyclo(3.3.1.1(sup 3,7))decane
Indication
Disease Entry ICD 11 Status REF
Influenza A virus infection 1E30 Approved [1]
Parkinsonian disorder Approved [2]
Postencephalitic Parkinson disease Approved [2]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
2130
ChEBI ID
CHEMBL660
CAS Number
CAS 768-94-5
TTD Drug ID
DMS3YE9
VARIDT Drug ID
DR00040
INTEDE Drug ID
DR2259
ACDINA Drug ID
D00027

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Influenza M2 protein (Influ M)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rimantadine DM5DWMU Influenza A virus infection 1E30 Approved [7]
TCN-032 DM9PVNJ Influenza virus infection 1E30-1E32 Phase 2 [8]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [9]
Spiro[piperidine-2,2-adamantane] DMWU9PV Discovery agent N.A. Investigative [10]
2-(1-adamantyl) piperidine DM05OJD Discovery agent N.A. Investigative [10]
Rimantadine isomer 2 DM3BEF7 Discovery agent N.A. Investigative [10]
2-(1-adamantyl) pyrrolidine DMMSFEU Discovery agent N.A. Investigative [10]
3-(2-adamantyl) pyrrolidine DMS98WA Discovery agent N.A. Investigative [10]
Spiro[pyrrolidine-2,2-adamantane] DMW48JD Discovery agent N.A. Investigative [10]
2-(1-adamantyl)-2-methyl-pyrrolidine DMIGRMV Discovery agent N.A. Investigative [10]
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Drug(s) Transported By Organic cation transporter 2 (SLC22A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [11]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [12]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [13]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [14]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [15]
Propranolol DM79NTF Angina pectoris BA40 Approved [16]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [17]
Metformin DM89QE1 Colorectal carcinoma Approved [18]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [16]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [19]
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Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [21]
Gefitinib DM15F0X Colon adenocarcinoma Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Selenium DM25CGV N. A. N. A. Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [25]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [28]
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Drug(s) Affected By Microtubule-associated protein 2 (MAP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [6]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Panobinostat DM58WKG Chronic graft versus host disease Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [27]
Leflunomide DMR8ONJ Arthritis FA20 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [36]
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Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
Clozapine DMFC71L Schizophrenia 6A20 Approved [44]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [45]
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Drug(s) Affected By 2'-5'-oligoadenylate synthase 2 (OAS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Testosterone enanthate DMB6871 N. A. N. A. Approved [48]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [49]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [50]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
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Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Testosterone enanthate DMB6871 N. A. N. A. Approved [48]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Influenza M2 protein (Influ M) TTXT3PU M2_I34A1 Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
2'-5'-oligoadenylate synthase 2 (OAS2) OT64CCTM OAS2_HUMAN Gene/Protein Processing [5]
Interferon alpha-inducible protein 27, mitochondrial (IFI27) OTI2XGIT IFI27_HUMAN Gene/Protein Processing [5]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Gene/Protein Processing [5]
Microtubule-associated protein 2 (MAP2) OT6UYT3X MTAP2_HUMAN Gene/Protein Processing [6]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Gene/Protein Processing [5]

References

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2 Amantadine FDA Label
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