Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT0O7H)

Drug Name
MK-886 Drug Info
Synonyms
MK-886; 118414-82-7; MK 886; MK886; 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid; UNII-080626SQ8C; QAOAOVKBIIKRNL-UHFFFAOYSA-N; L-663,536; CHEMBL29097; CHEBI:75390; L 663536; MK-886 (L-663,536); 080626SQ8C; 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid; 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-Alpha,Alpha-dimethyl-5-(1-methylethyl)- [CAS]; L-663536; SMR000466278
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
3651377
ChEBI ID
CHEBI:75390
CAS Number
CAS 118414-82-7
TTD Drug ID
DMT0O7H

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [9]
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [10]
Silymarin DMXBYQR N. A. N. A. Phase 4 [11]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [12]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [13]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [14]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [15]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [16]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [17]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [18]
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Drug(s) Affected By Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [27]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [28]
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Drug(s) Affected By Prostaglandin E synthase (PTGES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [29]
Selenium DM25CGV N. A. N. A. Approved [30]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Menthol DMG2KW7 Back pain ME84.Z Approved [35]
Mestranol DMG3F94 Contraception QA21 Approved [29]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [36]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
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Drug(s) Affected By Apolipoprotein A-I (APOA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [40]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [41]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [42]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [43]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [47]
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Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Selenium DM25CGV N. A. N. A. Approved [50]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [53]
Acitretin DM8BKU9 Psoriasis vulgaris EA90 Approved [54]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [55]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [62]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [33]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [65]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [67]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [68]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [69]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [70]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [71]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [72]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [73]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [74]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [75]
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Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [78]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [33]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [79]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
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Drug(s) Affected By DNA-directed DNA/RNA polymerase mu (POLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [83]
Gentamicin DMKINJO Bacteremia 1A73 Approved [83]
Bortezomib DMNO38U Leukemia Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [83]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [83]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [84]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [85]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [86]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [87]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [87]
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Drug(s) Affected By DNA polymerase kappa (POLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [26]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [88]
Paclitaxel DMLB81S Breast carcinoma Approved [89]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [91]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [92]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [85]
Guanine DMIWLJE N. A. N. A. Phase 3 [93]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [94]
680C91 DMCDTIG Solid tumour/cancer 2A00-2F9Z Preclinical [95]
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Drug(s) Affected By DNA polymerase iota (POLI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [85]
Urethane DM7NSI0 N. A. N. A. Phase 4 [98]
Guanine DMIWLJE N. A. N. A. Phase 3 [93]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [99]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [30]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [87]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [100]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Gene/Protein Processing [3]
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) OT0DH40W AL5AP_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [5]
DNA polymerase iota (POLI) OTBA4DCE POLI_HUMAN Gene/Protein Processing [6]
DNA polymerase kappa (POLK) OTKZ38JH POLK_HUMAN Gene/Protein Processing [6]
DNA-directed DNA/RNA polymerase mu (POLM) OT0SRIP4 DPOLM_HUMAN Gene/Protein Processing [6]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Gene/Protein Processing [7]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Gene/Protein Processing [7]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Gene/Protein Processing [8]
Retinoic acid receptor RXR-alpha (RXRA) OTP1TBDM RXRA_HUMAN Gene/Protein Processing [7]

References

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