Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVPZBE)

Drug Name
Iloprost Drug Info
Synonyms
Ciloprost; Endoprost; Ilomedin; Ilomedine; Iloprostum; Ventavis; Iloprostum [Latin]; ZK 36374; E-1030; Iloprost (INN); Iloprost [BAN:INN]; SH-401; Ventavis (TN); ZK-36374; ZK-363775; [3H]-Iloprost; (16R,S)-Methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandin I(sub 2); (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; (5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid; (5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; (5Z)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(E,3R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; (E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric acid; (E)-5-(3aS,4R,5R,6aS)-5-Hydroxy-4((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-inyl)perhydropentalen-2-yliden)valeriansaeure
Indication
Disease Entry ICD 11 Status REF
Pulmonary arterial hypertension BB01.0 Approved [1]
Pulmonary hypertension BB01 Approved [2]
Systemic sclerosis 4A42 Approved [2]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
5311181
ChEBI ID
CHEBI:63916
CAS Number
CAS 78919-13-8
TTD Drug ID
DMVPZBE
VARIDT Drug ID
DR00099

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin E2 receptor EP2 (PTGER2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [10]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [11]
Alprostadil DMWH7NQ Aorta coarctation Approved [12]
Omidenepag isopropyl DMUX7Z8 Glaucoma/ocular hypertension 9C61 Approved [13]
LAROPIPRANT DM5FABJ Coronary heart disease BA80.Z Phase 4 [14]
16,16-dimethyl-PGE2 DMNF38S Stem cell engraftment QB63.8 Phase 2 [15]
CP-533536 DMZEJLB Osteoporosis FB83.0 Phase 2 [16]
Taprenepag DM1TSHL Glaucoma/ocular hypertension 9C61 Phase 2 [17]
TPST-1495 DM3GSB2 Solid tumour/cancer 2A00-2F9Z Phase 1 [18]
PF-4418948 DMMETU8 Endometriosis GA10 Phase 1 [10]
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Drug(s) Transported By Organic anion transporting polypeptide 2A1 (SLCO2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [19]
Alprostadil DMWH7NQ Aorta coarctation Approved [4]
Latanoprost DMI5OXG Ocular hypertension 9C61.01 Approved [20]
PGF2alpha DM4XAU7 Solid tumour/cancer 2A00-2F9Z Clinical trial [4]
Drug(s) Transported By Organic anion transporting polypeptide 3A1 (SLCO3A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [5]
Alprostadil DMWH7NQ Aorta coarctation Approved [5]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [19]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [19]
PGF2alpha DM4XAU7 Solid tumour/cancer 2A00-2F9Z Clinical trial [5]
Drug(s) Affected By Angiopoietin-2 (ANGPT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Panobinostat DM58WKG Chronic graft versus host disease Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [26]
Propranolol DM79NTF Angina pectoris BA40 Approved [27]
Testosterone DM7HUNW Hot flushes GA30 Approved [28]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [28]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [29]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [32]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [33]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [35]
Selenium DM25CGV N. A. N. A. Approved [36]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [37]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [38]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [39]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [42]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [35]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
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Drug(s) Affected By Fibroblast growth factor 2 (FGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [45]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Diazepam DM08E9O Alcohol withdrawal Approved [47]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [48]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [49]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [52]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [53]
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Drug(s) Affected By L-selectin (SELL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [54]
Meloxicam DM2AR7L Arthritis FA20 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [57]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [54]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [58]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [54]
Phenylbutazone DMAYL0T Chronic pain MG30 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
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Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [65]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [66]
Leflunomide DMR8ONJ Arthritis FA20 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
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Drug(s) Affected By Prostacyclin receptor (PTGIR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [69]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [70]
cicaprost DM7ZJ4H Discovery agent N.A. Investigative [9]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [71]
Drug(s) Affected By Angiopoietin-1 (ANGPT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [76]
Panobinostat DM58WKG Chronic graft versus host disease Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin E2 receptor EP2 (PTGER2) TT1ZAVI PE2R2_HUMAN Agonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 2A1 (SLCO2A1) DT021JD SO2A1_HUMAN Substrate [4]
Organic anion transporting polypeptide 3A1 (SLCO3A1) DTVNRXW SO3A1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Gene/Protein Processing [6]
Angiopoietin-2 (ANGPT2) OTEQK65P ANGP2_HUMAN Gene/Protein Processing [6]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Gene/Protein Processing [7]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Gene/Protein Processing [6]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [8]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [8]
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Gene/Protein Processing [8]
Prostacyclin receptor (PTGIR) OTWTABYM PI2R_HUMAN Protein Interaction/Cellular Processes [9]

References

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2 Iloprost FDA Label
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32 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
33 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
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38 Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
39 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
40 Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
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60 Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Br J Pharmacol. 2014 Oct;171(19):4464-77. doi: 10.1111/bph.12803. Epub 2014 Sep 5.
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62 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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64 Study of As(2)O(3) regulating proliferation and apoptosis of Tca8113 cells by inhibiting the expression of Id-1. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1932-1937. doi: 10.1080/21691401.2019.1613419.
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66 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
67 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
68 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
69 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
70 Genetic and ethnic risk factors associated with drug hypersensitivity. Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):280-90. doi: 10.1097/ACI.0b013e32833b1eb3.
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72 Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
73 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
74 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
75 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
76 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.