Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW2KI5)

Drug Name

24(S), 25-epoxycholesterol Drug Info

Synonyms

24,25-epoxy-cholesterol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3247059
ChEBI ID: CHEMBL434302
CAS Number: CAS 77058-74-3
TTD Drug ID: DMW2KI5

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Patented Agent(s)

Approved Drug(s)

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Drug(s) Targeting Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VTB-38543	DMNY3J0	Atopic dermatitis	EA80	Phase 2	[5]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[6]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[7]
L-783483	DM6OTGE	Discovery agent	N.A.	Investigative	[8]
WAY-214950	DM8ODI7	Discovery agent	N.A.	Investigative	[9]
27-hydroxycholesterol	DM2L6OZ	Discovery agent	N.A.	Investigative	[10]
22R-hydroxycholesterol	DME8273	Discovery agent	N.A.	Investigative	[11]
GSK-9772	DM4WS3R	Discovery agent	N.A.	Investigative	[12]
Riccardin C	DM6MYGX	Discovery agent	N.A.	Investigative	[13]
2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione	DMH76SO	Discovery agent	N.A.	Investigative	[14]
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Drug(s) Targeting Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9073931, E2	DMK9FJG	N. A.	N. A.	Patented	[15]
BDBM50177019	DMEL28G	N. A.	N. A.	Patented	[16]
US9006244, E2b	DMP0TBO	N. A.	N. A.	Patented	[17]
US9073931, E1	DM2Z43I	N. A.	N. A.	Patented	[15]
US9006244, E1	DMBF1C0	N. A.	N. A.	Patented	[17]
BDBM50177012	DM52IQF	N. A.	N. A.	Patented	[16]
US9006244, E2a	DMPDF9B	N. A.	N. A.	Patented	[17]
67S	DMJL1MB	N. A.	N. A.	Patented	[16]
US9073931, E3	DMCYM8P	N. A.	N. A.	Patented	[15]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[7]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 15 (TNFSF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[23]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[24]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[26]
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Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[30]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[37]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[40]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[41]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[45]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[43]
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Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[49]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[50]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[4]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[51]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[53]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxysterols receptor LXR-alpha (NR1H3)	TTECBXN	NR1H3_HUMAN	Agonist	[2]
Oxysterols receptor LXR-beta (NR1H2)	TTXA6PH	NR1H2_HUMAN	Agonist	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[3]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Gene/Protein Processing	[3]
T-lymphocyte activation antigen CD80 (CD80)	OTJBLUQE	CD80_HUMAN	Gene/Protein Processing	[4]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15)	OTNGA2BW	TNF15_HUMAN	Gene/Protein Processing	[3]
Vascular cell adhesion protein 1	OTP74K37	VCAM1_HUMAN	Gene/Protein Processing	[3]

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References

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