Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWCQP4)

Drug Name

Interferon Alfa-2b Drug Info

Synonyms

Intron A; Viraferon

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Approved	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 71306834
CAS Number: CAS 98530-12-2
TTD Drug ID: DMWCQP4
ACDINA Drug ID: D01166

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Interferon-alpha 2 (IFNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Peginterferon alfa-2b	DMAP58Y	Hepatitis C virus infection	1E51.1	Approved	[2]
Peginterferon alfa-2a	DMJI3BA	Chronic hepatitis B virus infection		Approved	[2]
Albinterferon alfa-2b	DMK0QW6	Hepatitis C virus infection	1E51.1	Phase 3	[4]
Interferon alpha 2a	DMOTH6V	Hepatitis C virus infection	1E51.1	Phase 3	[5]
Hebergel	DMQTLVB	Virus infection	1A24-1D9Z	Phase 3	[6]
P-1101	DM7WYXJ	Essential thrombocythemia	3B63.1Z	Phase 3	[7]
Interferon alpha-2b	DMVACTU	Hepatitis C virus infection	1E51.1	Phase 2	[8]
Novaferon	DMEHOI1	Colorectal cancer	2B91.Z	Phase 2	[9]
Instiladrin	DMNKAFQ	Bladder cancer	2C94	Phase 2	[10]
CIGB-128	DMB2MKU	Basal cell carcinoma	2C32	Phase 1	[11]
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Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[16]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[17]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[18]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[19]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[20]
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Drug(s) Affected By Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[30]
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Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[36]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[37]
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Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[29]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interferon-alpha 2 (IFNA2)	TTSIUJ9	IFNA2_HUMAN	Modulator	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[3]
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)	OT8DXMS3	E2AK2_HUMAN	Gene/Protein Processing	[3]
Non-receptor tyrosine-protein kinase TYK2	OTHEOTA8	TYK2_HUMAN	Gene/Protein Processing	[3]
Signal transducer and activator of transcription 2 (STAT2)	OTO9G2RZ	STAT2_HUMAN	Post-Translational Modifications	[3]
Tyrosine-protein kinase JAK1 (JAK1)	OT0X3D17	JAK1_HUMAN	Gene/Protein Processing	[3]

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References

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