Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWQ16I)

Drug Name
Primaquine Drug Info
Synonyms
Kanaprim; Primachin; Primachina; Primachinum; Primaquin; Primaquina; Primaquinum; Primachina [DCIT]; SN 13272; WR 2975; Dl-Primaquine; Kanaprim (TN); Neo-Quipenyl; Primaquina [INN-Spanish]; Primaquine (INN); Primaquine Bis-Phosphoric Acid; Primaquine [INN:BAN]; Primaquinum [INN-Latin]; SN 13,272; TG1-296; TG1-297; Ethylbutylamino)-6-methoxyquinoline; S. N. 13272; N4-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine; Quinoline, 8-(4-amino-1-methylbutylamino)-6-methoxy; N(4)-(6-methoxyquinolin-8-yl)pentane-1,4-diamine; N-(5-aminopentan-2-yl)-6-methoxyquinolin-8-amine; N~4~-[6-(methyloxy)quinolin-8-yl]pentane-1,4-diamine; Quinoline, 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-(6CI,8CI); (+)-N4-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine; (+)-Primaquine; (+/-)-Primaquine; (-)-N4-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine; (-)-Primaquine; 1,4-Pentanediamine, N4-(6-methoxy-8-quinolinyl)-(9CI); 4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine; 6-Methoxy-8-(4-amino-1-methylbutylamino)quinoline; 6-Methoxy-8-[(4-amino-1-methylbutyl)amino]quinoline; 6-Methoxy-8-[4-amino-1-methylbutylamino]quinoline; 8-((4-Amino-1-methylbutyl)amino)-6-methoxyquinoline; 8-(4-Amino-1-m; 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline; 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [1]
Therapeutic Class
Antimalarials
Cross-matching ID
PubChem CID
4908
ChEBI ID
CHEMBL506
CAS Number
CAS 90-34-6
TTD Drug ID
DMWQ16I
INTEDE Drug ID
DR1339
ACDINA Drug ID
D00554

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [10]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [11]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [12]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [13]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [14]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [15]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [16]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [10]
Verapamil DMA7PEW Angina pectoris BA40 Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [19]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [20]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [21]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [22]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [15]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [6]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [27]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [27]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [28]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [6]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [27]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [8]
Gefitinib DM15F0X Colon adenocarcinoma Approved [6]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [29]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [5]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [5]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [37]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [40]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [44]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [46]
Methysergide DM1EF73 Migraine 8A80 Approved [8]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [49]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [50]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hemoglobin subunit gamma-2 (HBG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Testosterone enanthate DMB6871 N. A. N. A. Approved [55]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [7]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [56]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [57]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [58]
Butanoic Acid DMTAJP7 Discovery agent N.A. Investigative [59]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasmodium Deoxyribonucleic acid (Malaria DNA) TT698WO NOUNIPROTAC Not Available [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [5]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [6]
Hemoglobin subunit gamma-2 (HBG2) OT4J48JJ HBG2_HUMAN Gene/Protein Processing [7]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [5]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Gene/Protein Processing [8]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Gene/Protein Processing [5]

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