Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXLKHV)

Drug Name

Oxycodone Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Osteoarthritis	FA00-FA05	Approved	[1]
Pain	MG30-MG3Z	Approved	[2]
Back pain	ME84.Z	Phase 3	[3]

Therapeutic Class

Analgesics

Cross-matching ID

PubChem CID: 5284603
ChEBI ID: CHEBI:7852
CAS Number: CAS 76-42-6
TTD Drug ID: DMXLKHV
VARIDT Drug ID: DR00392
ACDINA Drug ID: D00502

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Opioid receptor mu (MOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[9]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[10]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[11]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[12]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[13]
Alfentanil	DMVO0UB	Anaesthesia	9A78.6	Approved	[14]
Naloxegol	DML0B41	Opioid-induced constipation	DB32.1	Approved	[15]
Eluxadoline	DMYZ0P1	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[16]
Nalfurafine hcl	DMA9DHW	Uremic pruritus	EC90.10	Approved	[17]
Methylnaltrexone bromide	DMZTGN2	Opioid-induced constipation	DB32.1	Approved	[12]
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Drug(s) Targeting Opioid receptor delta (OPRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Codeine	DMJX6ZG	Allergic rhinitis	CA08.0	Approved	[18]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[19]
Loperamide	DMOJZQ9	Diarrhea	ME05.1	Approved	[20]
Eluxadoline	DMYZ0P1	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[16]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[18]
Carfentanil	DM7ADGX	N. A.	N. A.	Phase 2	[21]
Met-enkephalin	DMSZFTP	Pain	MG30-MG3Z	Phase 2	[22]
AZD-2327	DM8FZOG	Anxiety disorder	6B00-6B0Z	Phase 2	[23]
ADL-5747	DMMUPTN	Pain	MG30-MG3Z	Phase 2	[24]
ADL-5859	DMDQH9A	Rheumatoid arthritis	FA20	Phase 2	[24]
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Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[25]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[29]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[32]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[33]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[34]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[38]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[39]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[41]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[42]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[25]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Selenium	DM25CGV	N. A.	N. A.	Approved	[45]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[46]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[32]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[47]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[48]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[53]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[54]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[55]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[56]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[57]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[58]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[59]
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Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[61]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[62]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[64]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[65]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[66]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[55]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[67]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[68]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor delta (OPRD1)	TT27RFC	OPRD_HUMAN	Agonist	[4]
Opioid receptor mu (MOP)	TTKWM86	OPRM_HUMAN	Modulator	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Gene/Protein Processing	[6]
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Drug Response	[7]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Regulation of Drug Effects	[8]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Gene/Protein Processing	[6]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Post-Translational Modifications	[6]

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References

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