Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYWRL6)

Drug Name
Purpurin Drug Info
Synonyms
PURPURIN; 81-54-9; 1,2,4-Trihydroxyanthraquinone; Purpurine; Verantin; Hydroxylizaric acid; Smoke Brown G; 1,2,4-trihydroxyanthracene-9,10-dione; 1,2,4-Trihydroxy-9,10-anthracenedione; 1,2,4-Trihydroxy-9,10-anthraquinone; 1,2,4-Trihydroxyanthrachinon; C.I. 58205; 9,10-Anthracenedione, 1,2,4-trihydroxy-; 1,2,4-Trihydroxyanthra-9,10-quinone; UNII-L1GT81LS6N; Anthraquinone, 1,2,4-trihydroxy-; C.I. 75410; CHEBI:8645; CCRIS 3527; C.I. 1037; EINECS 201-359-8; NSC 10447; 1,2,4-Trihydroxyanthrachinon [Czech]; BRN 1887127; L1GT81LS6N
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6683
ChEBI ID
CHEBI:8645
CAS Number
CAS 81-54-9
TTD Drug ID
DMYWRL6

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Human immunodeficiency virus Integrase (HIV IN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dolutegravir DMCZGRE Human immunodeficiency virus infection 1C62 Approved [6]
Raltegravir DMYURI6 Human immunodeficiency virus infection 1C62 Approved [7]
Elvitegravir DMG9B1U Human immunodeficiency virus infection 1C62 Approved [6]
Bictegravir, emtricitabine and tenofovir alafenamide DMG0H8K Human immunodeficiency virus infection 1C62 Approved [8]
GSK1265744 DMT8J0I Human immunodeficiency virus infection 1C62 Phase 3 [9]
S-1360 DM9KTSG Human immunodeficiency virus infection 1C62 Phase 2 [10]
S-364735 DMU7ZMH Human immunodeficiency virus infection 1C62 Phase 2 [11]
C-2507 DMOFT1V Human immunodeficiency virus infection 1C62 Phase 1 [12]
Acriflavine DMKVE8X Human immunodeficiency virus infection 1C62 Phase 1 [13]
S-265744 LAP DMDQRWT Human immunodeficiency virus infection 1C62 Phase 1 [14]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [15]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [16]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [17]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Ethacrynic acid DM60QMR Edema MG29 Approved [21]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [22]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [23]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [24]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Estrone DM5T6US Acne vulgaris ED80 Approved [28]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [29]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [30]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [31]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [32]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [33]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [34]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [34]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [34]
Capsaicin DMGMF6V Back pain ME84.Z Approved [35]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [36]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [37]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [38]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [39]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [40]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [41]
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Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fomepizole DM6VOWQ Athylene glycol or methanol poisoning NE61 Approved [42]
Ademetionine DMYQDBO Hepatic fibrosis DB93.0 Approved [43]
Theophylline DMRJFN9 Bronchitis CA20 Approved [41]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [44]
Ethanol DMDRQZU Chronic pain MG30 Approved [45]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [46]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [41]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [49]
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Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [50]
Methoxsalen DME8FZ9 Cutaneous T-cell lymphoma 2B01 Approved [51]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [46]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [54]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [57]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [58]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [59]
Gefitinib DM15F0X Colon adenocarcinoma Approved [60]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [61]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [62]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [67]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [68]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [69]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [70]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [72]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Verapamil DMA7PEW Angina pectoris BA40 Approved [74]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [75]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [76]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [77]
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Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [80]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [81]
Capsaicin DMGMF6V Back pain ME84.Z Approved [35]
Zafirlukast DMHNQOG Asthma CA23 Approved [82]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [80]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [83]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [81]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [80]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [84]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [77]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [86]
Gefitinib DM15F0X Colon adenocarcinoma Approved [60]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Selenium DM25CGV N. A. N. A. Approved [89]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [90]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [91]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [92]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [93]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [77]
Gefitinib DM15F0X Colon adenocarcinoma Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [97]
Selenium DM25CGV N. A. N. A. Approved [89]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [98]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [90]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [49]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [81]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [99]
Capsaicin DMGMF6V Back pain ME84.Z Approved [35]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [80]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [37]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [80]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [49]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [41]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [102]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [103]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [104]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [105]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [106]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [107]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [108]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [109]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [110]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [75]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [114]
Meloxicam DM2AR7L Arthritis FA20 Approved [115]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [116]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [117]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [69]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [109]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Verapamil DMA7PEW Angina pectoris BA40 Approved [74]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [118]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [112]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
Meloxicam DM2AR7L Arthritis FA20 Approved [120]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [121]
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Drug(s) Affected By Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [122]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [126]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [127]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [128]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [129]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [130]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [131]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human immunodeficiency virus Integrase (HIV IN) TT5FH9Y POL_HV1B1 Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [2]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [3]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [4]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [3]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Gene/Protein Processing [5]

References

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2 Purpurin binding interacts with LHPP protein that inhibits PI3K/AKT phosphorylation and induces apoptosis in colon cancer cells HCT-116. J Biochem Mol Toxicol. 2021 Mar;35(3):e22665. doi: 10.1002/jbt.22665. Epub 2020 Dec 28.
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5 Anthraquinones inhibit cytochromes P450 enzyme activity in silico and in vitro. J Appl Toxicol. 2021 Sep;41(9):1438-1445. doi: 10.1002/jat.4134. Epub 2021 Jan 12.
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16 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
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31 Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
32 Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
33 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
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35 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
36 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
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39 Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2003 Nov;31(11):1352-60.
40 Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
41 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
42 Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity. Eur J Drug Metab Pharmacokinet. 2011 Mar;36(1):1-16.
43 Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93.
44 Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
45 An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells. Toxicol Sci. 2013 Mar;132(1):131-41.
46 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
47 Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
48 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
49 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
50 Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans. Drug Metab Dispos. 2005 Sep;33(9):1361-6. doi: 10.1124/dmd.105.004796. Epub 2005 Jun 24.
51 Mimicking gene defects to treat drug dependence. Ann N Y Acad Sci. 2000;909:233-46. doi: 10.1111/j.1749-6632.2000.tb06685.x.
52 Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur. Jpn J Cancer Res. 2001 May;92(5):524-8. doi: 10.1111/j.1349-7006.2001.tb01125.x.
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