Details of the Drug-Related molecule(s) Interaction Atlas

Nitrosoglutathione Drug Info

Glutathione thionitrite; Nitrosoglutathione; S-nitrosoglutathione; S-NITROSO-L-GLUTATHIONE; (2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-(nitrososulfanyl)ethyl]carbamoyl}butanoic acid; (S)-2-Amino-5-(((R)-1-((carboxymethyl)amino)-3-(nitrosothio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid; 57564-91-7; 78RRI89ZTO; BRN 3566211; C10H16N4O7S; CCRIS 2095; CHEBI:50091; Glycine, N-(N-L-gamma-glutamyl-S-nitroso-L-cysteinyl)-; N-(N-L-gamma-Glutamyl-S-nitroso-L-cysteinyl)glycine; SNOG; UNII-78RRI89ZTO; gsno

Cross-matching ID

PubChem CID

104858

ChEBI ID

CHEMBL50091

CAS Number

CAS 57564-91-7

TTD Drug ID

DMZ9WI4

INTEDE Drug ID

DR2448

General Information of Drug (ID: DMZ9WI4)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Metabolized By S-(hydroxymethyl)glutathione dehydrogenase (adh)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitroprusside	DMLUA2J	Hypertension	BA00-BA04	Approved	[1]
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Drug(s) Affected By Serine protease HTRA2, mitochondrial (HTRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[14]
Bortezomib	DMNO38U	Leukemia		Approved	[15]
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Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[2]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[23]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[24]
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Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[2]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[27]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[30]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[31]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[32]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[33]
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Drug(s) Affected By Transcription factor Sp3 (SP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[38]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[42]
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Drug(s) Affected By Carbonyl reductase 1 (CBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[47]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[49]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[50]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[48]
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Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[57]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
S-(hydroxymethyl)glutathione dehydrogenase (adh)^{Main DME}	DEAH3PE	A0A0A7DS01_VIBCL	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Protein Interaction/Cellular Processes	[2]
Carbonyl reductase 1 (CBR1)	OTQ3A541	CBR1_HUMAN	Biotransformations	[3]
Interleukin-12 subunit beta (IL12B)	OT0JF8A3	IL12B_HUMAN	Gene/Protein Processing	[2]
Serine protease HTRA2, mitochondrial (HTRA2)	OTC7616F	HTRA2_HUMAN	Protein Interaction/Cellular Processes	[4]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Drug Response	[5]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Gene/Protein Processing	[6]

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