Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZD0NA)

Drug Name
torin 1 Drug Info
Synonyms Torin-1
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
49836027
ChEBI ID
CHEBI:84327
CAS Number
CAS 1222998-36-8
TTD Drug ID
DMZD0NA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Serine/threonine-protein kinase mTOR (mTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [7]
Temsirolimus DMS104F Renal cell carcinoma 2C90 Approved [8]
PF-04449913 DMSB068 Chronic myelomonocytic leukaemia 2A40 Approved [9]
Everolimus DM8X2EH Advanced cancer 2A00-2F9Z Approved [10]
Novolimus DM6ZPLQ Artery stenosis BD52 Approved [11]
Zotarolimus DMRMCXW Solid tumour/cancer 2A00-2F9Z Approved [12]
Ridaforolimus DMLHEU7 Sarcoma 2A60-2C35 Phase 3 [13]
AZD2014 DMOEARH Solid tumour/cancer 2A00-2F9Z Phase 2 [14]
MM-141 DM2RJ4D Pancreatic cancer 2C10 Phase 2 [15]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [11]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [18]
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [21]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [25]
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Drug(s) Affected By Polyadenylate-binding protein 1 (PABPC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [32]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [33]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [34]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [35]
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Drug(s) Affected By Elongation factor 2 (EEF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [28]
Paclitaxel DMLB81S Breast carcinoma Approved [38]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [32]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [40]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [41]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
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Drug(s) Affected By Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [45]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Fructose DM43AN2 Vomiting MD90 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [43]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [50]
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Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [51]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [18]
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
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Drug(s) Affected By Small ribosomal subunit protein uS10 (RPS20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [28]
Menthol DMG2KW7 Back pain ME84.Z Approved [59]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [61]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [33]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [63]
Rapamycin Immunosuppressant Drug DM678IB Discovery agent N.A. Investigative [3]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [64]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [67]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [70]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [71]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [73]
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Drug(s) Affected By Large ribosomal subunit protein eL32 (RPL32)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [28]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [35]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [76]
Milchsaure DM462BT Pruritus EC90 Investigative [77]
Rapamycin Immunosuppressant Drug DM678IB Discovery agent N.A. Investigative [3]
GALLICACID DM6Y3A0 Discovery agent N.A. Investigative [78]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [21]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [83]
Testosterone DM7HUNW Hot flushes GA30 Approved [70]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
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Drug(s) Affected By La-related protein 1 (LARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [26]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [87]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [32]
G1 DMTV42K Lymphoma 2A80-2A86 Phase 1/2 [88]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [89]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase mTOR (mTOR) TTCJG29 MTOR_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Elongation factor 2 (EEF2) OTZ7SZ39 EF2_HUMAN Post-Translational Modifications [3]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [3]
La-related protein 1 (LARP1) OT5HPUOA LARP1_HUMAN Drug Response [3]
Large ribosomal subunit protein eL32 (RPL32) OTKRQJT4 RL32_HUMAN Gene/Protein Processing [3]
Polyadenylate-binding protein 1 (PABPC1) OT54LG0P PABP1_HUMAN Gene/Protein Processing [3]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Post-Translational Modifications [4]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Post-Translational Modifications [5]
Serine/threonine-protein kinase ULK1 OTXNP0N5 ULK1_HUMAN Gene/Protein Processing [6]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Gene/Protein Processing [3]
Small ribosomal subunit protein uS10 (RPS20) OTI8052R RS20_HUMAN Gene/Protein Processing [3]

References

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21 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
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23 Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
24 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
25 Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
26 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
27 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
28 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
29 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
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31 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
32 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
33 Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
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35 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
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37 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
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39 Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome. Chem Res Toxicol. 2022 Sep 19;35(9):1589-1597. doi: 10.1021/acs.chemrestox.2c00197. Epub 2022 Aug 22.
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44 The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces. Br J Haematol. 2003 Jan;120(2):315-24. doi: 10.1046/j.1365-2141.2003.03971.x.
45 Mechanisms of tissue factor induction by the uremic toxin indole-3 acetic acid through aryl hydrocarbon receptor/nuclear factor-kappa B signaling pathway in human endothelial cells. Arch Toxicol. 2019 Jan;93(1):121-136.
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47 Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells. J Thromb Haemost. 2003 May;1(5):1089-95. doi: 10.1046/j.1538-7836.2003.00217.x.
48 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
49 Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents. Leukemia. 1999 Jul;13(7):1062-70. doi: 10.1038/sj.leu.2401448.
50 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
51 Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 2004 Apr 15;103(8):3138-47. doi: 10.1182/blood-2003-05-1543. Epub 2003 Dec 24.
52 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
53 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
54 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
55 SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
56 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
57 D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells. Biochem Biophys Res Commun. 2009 Apr 24;382(1):96-101. doi: 10.1016/j.bbrc.2009.02.129. Epub 2009 Feb 28.
58 Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells. Cancer Res. 2003 Nov 15;63(22):7950-8.
59 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
60 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
61 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
62 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
63 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
64 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
65 Cannabidiol Reduces Leukemic Cell Size - But Is It Important?. Front Pharmacol. 2017 Mar 24;8:144. doi: 10.3389/fphar.2017.00144. eCollection 2017.
66 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
67 Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem Biol Drug Des. 2011 Dec;78(6):999-1005. doi: 10.1111/j.1747-0285.2011.01239.x. Epub 2011 Oct 31.
68 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
69 Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging (Albany NY). 2012 Dec;4(12):952-65. doi: 10.18632/aging.100521.
70 Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival. Anticancer Res. 2010 Oct;30(10):3895-901.
71 Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food Chem Toxicol. 2022 Apr;162:112869. doi: 10.1016/j.fct.2022.112869. Epub 2022 Feb 16.
72 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
73 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
74 In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
75 Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
76 Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
77 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
78 Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
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