Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZLGRB)

Drug Name
Pimecrolimus Drug Info
Synonyms Elidel; ASM 981; SDZ ASM 981; ASM-981; ASM-998; Elidel (TN); SDZ-ASM 981; Pimecrolimus [USAN:INN:BAN]; SDZ-ASM-981; Pimecrolimus (JAN/USAN/INN); 33-epi-Chloro-33-desoxyascomycin
Indication
Disease Entry ICD 11 Status REF
Atopic dermatitis EA80 Approved [1]
Therapeutic Class
Dermatologic Agents
Cross-matching ID
PubChem CID
6509979
ChEBI ID
CHEMBL1200686
CAS Number
CAS 137071-32-0
TTD Drug ID
DMZLGRB
INTEDE Drug ID
DR1289

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Calcineurin (PPP3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Voclosporin DMWIJTN Lupus nephritis 4A40.0Y Approved [9]
L-685,818 DMJUQT1 Discovery agent N.A. Investigative [10]
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [11]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [12]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [13]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [14]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [15]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [16]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [17]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [18]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [12]
Verapamil DMA7PEW Angina pectoris BA40 Approved [19]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [20]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [21]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [21]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [22]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [20]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [21]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [20]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [4]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [24]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [24]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [25]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [27]
Etidronic acid DM1XHYJ Bone Paget disease Approved [24]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [24]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [24]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [28]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [31]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [32]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [33]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [34]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [5]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [35]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Folic Acid DMEMBJC Colorectal carcinoma Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Menthol DMG2KW7 Back pain ME84.Z Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [45]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [46]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calcineurin (PPP3CA) TTA4LDE PP2BA_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [4]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Gene/Protein Processing [5]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Protein Interaction/Cellular Processes [6]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) OTDK74C0 TNR4_HUMAN Gene/Protein Processing [5]

References

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23 Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4.
24 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
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26 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
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29 Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
30 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
31 Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol. 2008 May 15;180(10):6988-96. doi: 10.4049/jimmunol.180.10.6988.
32 Down-regulation of interleukin-2 receptor gene activation and protein expression by dideoxynucleoside analogs. Cell Immunol. 1995 Jul;163(2):289-95. doi: 10.1006/cimm.1995.1128.
33 Ouabain induces inhibition of the progression phase in human T-cell proliferation. J Cell Physiol. 1995 Nov;165(2):246-53. doi: 10.1002/jcp.1041650205.
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38 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
39 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
40 Simvastatin reduces OX40 and OX40 ligand expression in human peripheral blood mononuclear cells and in patients with atherosclerotic cerebral infarction. J Int Med Res. 2009 May-Jun;37(3):601-10. doi: 10.1177/147323000903700302.
41 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
42 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
43 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
44 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
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