Details of Disease

Disease Name

Serum sickness

serum reaction; intoxication by serum; protein sickness; sickness, serum; Sicknesses, serum; serum Sicknesses; transfusion reaction due to serum protein reaction; serum sickness

Definition

Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis B) may also cause serum sickness-like reaction.

Disease Hierarchy

DISPBWVK: Type IV hypersensitivity disease

DISFL6YG: Type III hypersensitivity disease

DIS0MRKJ: Serum sickness

Disease Identifiers

MONDO ID

MONDO_0043789

MESH ID

D012713

UMLS CUI

C0036830

MedGen ID

11390

SNOMED CT ID

213323001

General Information of Disease (ID: DIS0MRKJ)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 8 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Betamethasone	DMAHJEF	Approved	Small molecular drug	[1]
Cortisone Acetate	DMG8K57	Approved	Small molecular drug	[2]
Dexamethasone	DMMWZET	Approved	Small molecular drug	[3]
Hydrocortisone	DMGEMB7	Approved	Small molecular drug	[4]
Methylprednisolone	DM4BDON	Approved	Small molecular drug	[5]
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[6]
Prednisone	DM2HG4X	Approved	Small molecular drug	[7]
Triamcinolone	DM98IXF	Approved	Small molecular drug	[8]
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⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCDC62	OTTIAOBP	Definitive	Biomarker	[9]
CSN1S1	OTXOW6XJ	Definitive	Biomarker	[10]
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References

1	Betamethasone FDA Label
2	Cortisone acetate FDA Label
3	Dexamethasone FDA Label
4	Hydrocortisone FDA Label
5	Methylprednisolone FDA Label
6	Prednisolone FDA Label
7	Prednisone FDA Label
8	Triamcinolone FDA Label
9	Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity.Int J Cancer. 2009 May 15;124(10):2347-52. doi: 10.1002/ijc.24220.
10	Autoantibodies to S1-casein are induced by breast-feeding.PLoS One. 2012;7(4):e32716. doi: 10.1371/journal.pone.0032716. Epub 2012 Apr 4.