Details of Disease

General Information of Disease (ID: DIS0VUZL)

• Disease Name: Osteomyelitis
• Synonyms: osteomyelitis; osteomyelitis (disease)
• Definition: An acute or chronic inflammation of the bone and its structures due to infection with pyogenic bacteria.
• Disease Hierarchy:
  DIS582WT: Bone marrow disorder
  DISTZXME: Bone inflammation disease
  DIS0VUZL: Osteomyelitis
• Disease Identifiers:
  MONDO ID: MONDO_0005246
  MESH ID: D010019
  UMLS CUI: C0029443
  MedGen ID: 10497
  HPO ID: HP:0002754
  SNOMED CT ID: 60168000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amikacin	DM5PDRB	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
RNF34	TTEWDK1	Limited	Biomarker	[2]
CLCN7	TTST1AJ	Strong	Genetic Variation	[3]
IL1RN	TT6GSR3	Strong	Biomarker	[4]
LCT	TTA0OSE	Strong	Biomarker	[5]
NCF1	TTZ4JC3	Strong	Genetic Variation	[6]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC9A6	DTN0JXW	Definitive	Biomarker	[7]

This Disease Is Related to 17 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
C1orf52	OT8RQW3W	Limited	Biomarker	[8]
DERL1	OTJUS74N	Limited	Genetic Variation	[9]
FCF1	OTTI9M2D	Limited	Biomarker	[10]
IL12RB1	OTM1IJO2	Limited	Genetic Variation	[11]
LRRC4	OT7XJ70N	Limited	Biomarker	[8]
MBD4	OTWR9YXE	Limited	Biomarker	[12]
MOXD1	OTUMCWRN	Limited	Biomarker	[2]
RHOF	OTPA3F8Q	Limited	Biomarker	[2]
SF1	OTLEDM2S	Limited	Biomarker	[13]
SUMF2	OT37I8JL	Limited	Biomarker	[14]
TBX22	OTT1RM26	Limited	Biomarker	[15]
TM2D1	OTWA4YSR	Limited	Biomarker	[13]
TMEM158	OT0KUBBI	Limited	Biomarker	[13]
TP53BP2	OTOWJ2Y4	Limited	Biomarker	[13]
IFNGR1	OTCTQBWW	moderate	Genetic Variation	[16]
CARD9	OTJ81AWD	Strong	Biomarker	[17]
PSTPIP2	OTG6F93V	Strong	Biomarker	[4]

References

• [1] Amikacin FDA Label
• [2] Preparation, in vitro release and antibacterial activity evaluation of rifampicin and moxifloxacin-loaded poly(D,L-lactide-co-glycolide) microspheres.Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):790-798. doi: 10.1080/21691401.2019.1581792.
• [3] Autosomal dominant osteopetrosis: clinical severity and natural history of 94 subjects with a chloride channel 7 gene mutation.J Clin Endocrinol Metab. 2007 Mar;92(3):771-8. doi: 10.1210/jc.2006-1986. Epub 2006 Dec 12.
• [4] Update on the genetics of nonbacterial osteomyelitis in humans.Curr Opin Rheumatol. 2018 Sep;30(5):521-525. doi: 10.1097/BOR.0000000000000530.
• [5] The Impacts of msaABCR on sarA-Associated Phenotypes Are Different in Divergent Clinical Isolates of Staphylococcus aureus.Infect Immun. 2020 Jan 22;88(2):e00530-19. doi: 10.1128/IAI.00530-19. Print 2020 Jan 22.
• [6] Treatment with rhG-CSF for osteomyelitis in a patient with p47-phox-deficient chronic granulomatous disease.Ann Hematol. 1997 Nov-Dec;75(5-6):243-6. doi: 10.1007/s002770050351.
• [7] Septic Arthritis of the Hip-Risk Factors Associated With Secondary Surgery.J Am Acad Orthop Surg. 2019 May 1;27(9):321-326. doi: 10.5435/JAAOS-D-18-00058.
• [8] Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections - A Multinational Study.Adv Exp Med Biol. 2017;971:81-92. doi: 10.1007/5584_2016_156.
• [9] Association of pyoderma gangrenosum and sterile osteomyelitis in a patient having myelodysplastic syndrome with der(1;7)(q10;q10).Eur J Haematol. 2004 Feb;72(2):149-53. doi: 10.1046/j.0902-4441.2003.00191.x.
• [10] Arthroscopic versus open ankle arthrodesis.Foot Ankle Surg. 2018 Apr;24(2):137-142. doi: 10.1016/j.fas.2017.01.004. Epub 2017 Feb 3.
• [11] Cryptococcal osteomyelitis in a child with a novel compound mutation of the IL12RB1 gene.Asian Pac J Allergy Immunol. 2012 Mar;30(1):79-82.
• [12] Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3.Histochem Cell Biol. 2009 Feb;131(2):207-18. doi: 10.1007/s00418-008-0522-8. Epub 2008 Oct 17.
• [13] A bone sialoprotein-binding protein from Staphylococcus aureus: a member of the staphylococcal Sdr family.Biochem J. 2000 Feb 1;345 Pt 3(Pt 3):611-9.
• [14] Staphylococcus aureus osteoarticular infections in children: an 8-year review of molecular microbiology, antibiotic resistance and clinical characteristics.J Med Microbiol. 2018 Dec;67(12):1753-1760. doi: 10.1099/jmm.0.000859. Epub 2018 Oct 23.
• [15] Dual effect biodegradable ciprofloxacin loaded implantable matrices for osteomyelitis: controlled release and osteointegration.Drug Dev Ind Pharm. 2018 Jun;44(6):1023-1033. doi: 10.1080/03639045.2018.1430820. Epub 2018 Mar 14.
• [16] Multifocal Recurrent Osteomyelitis and Hemophagocytic Lymphohistiocytosis in a Boy with Partial Dominant IFN-R1 Deficiency: Case Report and Review of the Literature.Front Pediatr. 2017 May 3;5:75. doi: 10.3389/fped.2017.00075. eCollection 2017.
• [17] The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis.J Biol Chem. 2020 Mar 13;295(11):3394-3400. doi: 10.1074/jbc.RA119.010623. Epub 2019 Nov 12.