Details of Disease

General Information of Disease (ID: DIS90QDN)

• Disease Name: Angioedema
• Synonyms: angioneurotic edema; angioneurotic oedema; angioedemas; Quinckes oedema; Edemas, angioneurotic; edema, angioneurotic; edema, Quincke's; Quincke's edema; Quincke's oedema; angioneurotic Edemas; Quincke oedema; Urticarias, giant; giant urticaria; Quinckes edema; Quincke edema; giant Urticarias; urticaria, giant
• Disease Class: 4A00: Innate/adaptive immunodeficiency
• Definition: Swelling involving the deep dermis, subcutaneous, or submucosal tissues, representing localized edema. Angioedema often occurs in the face, lips, tongue, and larynx.
• Disease Hierarchy:
  DIS2TMQU: Skin vascular disease
  DIS9WQAI: Urticaria
  DIS90QDN: Angioedema
• ICD Code: ICD-11: ICD-11: 4A00.15
• Disease Identifiers:
  MONDO ID: MONDO_0010481
  MESH ID: D000799
  UMLS CUI: C0002994
  MedGen ID: 1543
  HPO ID: HP:0100665
  SNOMED CT ID: 400075008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 11 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Betamethasone	DMAHJEF	Approved	Small molecular drug	[1]
Cortisone Acetate	DMG8K57	Approved	Small molecular drug	[2]
Dexamethasone	DMMWZET	Approved	Small molecular drug	[3]
Hydrocortisone	DMGEMB7	Approved	Small molecular drug	[4]
Methdilazine	DMAUHQX	Approved	Small molecular drug	[5]
Methylprednisolone	DM4BDON	Approved	Small molecular drug	[6]
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[7]
Prednisone	DM2HG4X	Approved	Small molecular drug	[8]
Promazine	DMZAL7W	Approved	Small molecular drug	[9]
Triamcinolone	DM98IXF	Approved	Small molecular drug	[10]
Trimeprazine	DMEMV9D	Approved	Small molecular drug	[11]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
TG100-115	DMON4IL	Phase 1/2	Small molecular drug	[12]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PLAT	TTXAGYU	moderate	Biomarker	[13]
HLA-DRB1	TTUXSTW	Strong	Biomarker	[14]
XPNPEP2	TTI9MBZ	Strong	Biomarker	[15]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABI3BP	OTW8DN50	Limited	Genetic Variation	[16]
IFT43	OTKWYQ5C	Limited	Genetic Variation	[16]
HLA-DPB1	OTW8JHU2	Strong	Biomarker	[14]
HLA-DQB1	OTVVI3UI	Strong	Biomarker	[14]

References

• [1] Betamethasone FDA Label
• [2] Cortisone acetate FDA Label
• [3] Dexamethasone FDA Label
• [4] Hydrocortisone FDA Label
• [5] Methdilazine FDA Label
• [6] Methylprednisolone FDA Label
• [7] Prednisolone FDA Label
• [8] Prednisone FDA Label
• [9] Promazine FDA Label
• [10] Triamcinolone FDA Label
• [11] Trimeprazine FDA Label
• [12] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5715).
• [13] Neurological picture. Orolingual angio-oedema after alteplase therapy in a stroke patient concurrently using angiotensin II receptor blocker.J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1079. doi: 10.1136/jnnp.2009.194878. Epub 2010 Jun 14.
• [14] The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. Clin Exp Allergy. 2005 Mar;35(3):339-44. doi: 10.1111/j.1365-2222.2004.02197.x.
• [15] A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors.Am J Hum Genet. 2005 Oct;77(4):617-26. doi: 10.1086/496899. Epub 2005 Sep 1.
• [16] Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.Pharmacogenomics. 2013 Nov;14(15):1857-69. doi: 10.2217/pgs.13.166.