Details of Disease

General Information of Disease (ID: DISA7SH0)

Disease Name	Alcoholic hepatitis
Synonyms	alcoholic hepatitis; alcoholic Hepatitis; acute alcoholic liver disease; acute alcoholic hepatitis; acute alcoholic Hepatitis
Disease Class	DB94: Alcoholic liver disease
Definition	Acute hepatitis resulting from ingestion of alcohol.
Disease Hierarchy	DISXXX35: Hepatitis DISXEPHQ: Alcoholic liver diseases DISA7SH0: Alcoholic hepatitis
ICD Code	ICD-11 ICD-11: DB94.1 ICD-10 ICD-10: K70.1 ICD-9 ICD-9: 571.1 Expand ICD-11 'DB94.1 Expand ICD-10 'K70.1 Expand ICD-9 571.1
Disease Identifiers	MONDO ID MONDO_0001505 MESH ID D006519 UMLS CUI C0019187 MedGen ID 42422 SNOMED CT ID 235875008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Oxandrolone	DMU9MYJ	Approved	Small molecular drug	[1]
Pentoxifylline	DMU3DNC	Approved	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CCL5	TT9DWLC	Strong	Biomarker	[3]
DDC	TTN451K	Strong	Biomarker	[4]
HCAR2	TTWNV8U	Strong	Biomarker	[5]
TICAM1	TT2GQT6	Strong	Biomarker	[6]
TNF	TTF8CQI	Strong	Altered Expression	[7]
PNPLA3	TTEUAEH	Definitive	Genetic Variation	[8]
STS	TTHM0R1	Definitive	Biomarker	[9]
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⏷ Show the Full List of 7 DTT(s)

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP7A1	DEDZRQ1	Strong	Altered Expression	[10]
SULT1E1	DESTKG6	Definitive	Biomarker	[9]
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This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AGA	OTNWT1WB	Strong	Biomarker	[11]
CIDEC	OTMDZ56K	Strong	Altered Expression	[12]
GSDMD	OTH39BKI	Strong	Biomarker	[13]
NAIP	OTLA925F	Strong	Altered Expression	[14]
NOSTRIN	OT0LDSGS	Strong	Genetic Variation	[15]
PMCH	OT3D9SA4	Strong	Altered Expression	[7]
TRA2B	OTZYQW52	Strong	Altered Expression	[16]
TRIM69	OTTEGTRD	Strong	Biomarker	[6]
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⏷ Show the Full List of 8 DOT(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7092).
2	Pentoxifylline FDA Label
3	Tumor necrosis factor alpha (TNF-alpha)-induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase: roles of TNF-alpha in alcoholic liver diseases.J Hepatol. 2003 Apr;38(4):483-9. doi: 10.1016/s0168-8278(02)00456-7.
4	Altered regulation of miR-34a and miR-483-3p in alcoholic hepatitis and DDC fed mice.Exp Mol Pathol. 2015 Dec;99(3):552-7. doi: 10.1016/j.yexmp.2015.09.005. Epub 2015 Sep 25.
5	-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway.J Hepatol. 2018 Sep;69(3):687-696. doi: 10.1016/j.jhep.2018.04.004. Epub 2018 Apr 27.
6	TLR3/4 signaling is mediated via the NFB-CXCR4/7 pathway in human alcoholic hepatitis and non-alcoholic steatohepatitis which formed Mallory-Denk bodies.Exp Mol Pathol. 2014 Oct;97(2):234-40. doi: 10.1016/j.yexmp.2014.07.001. Epub 2014 Jul 2.
7	4-Methylcoumarin-[5,6-g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR- activation.Toxicology. 2019 Jun 1;421:9-21. doi: 10.1016/j.tox.2019.04.004. Epub 2019 Apr 3.
8	Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis.J Hepatol. 2017 Jul;67(1):120-127. doi: 10.1016/j.jhep.2017.01.018. Epub 2017 Feb 2.
9	Inflammatory regulation of steroid sulfatase: a novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. J Hepatol. 2016 Jan;64(1):44-52.
10	Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis.J Hepatol. 2018 Aug;69(2):396-405. doi: 10.1016/j.jhep.2018.03.031. Epub 2018 Apr 12.
11	Medical Management of Severe Alcoholic Hepatitis: ExpertReview from the Clinical Practice Updates Committee ofthe AGA Institute.Clin Gastroenterol Hepatol. 2017 Jan;15(1):5-12. doi: 10.1016/j.cgh.2016.08.047.
12	Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.Gastroenterology. 2015 Oct;149(4):1030-41.e6. doi: 10.1053/j.gastro.2015.06.009. Epub 2015 Jun 20.
13	Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients.Hepatology. 2018 May;67(5):1737-1753. doi: 10.1002/hep.29645. Epub 2018 Feb 27.
14	The inflammasome in alcoholic hepatitis: Its relationship with Mallory-Denk body formation.Exp Mol Pathol. 2014 Oct;97(2):305-13. doi: 10.1016/j.yexmp.2014.08.006. Epub 2014 Aug 19.
15	Increased gene and protein expression of the novel eNOS regulatory protein NOSTRIN and a variant in alcoholic hepatitis.Gastroenterology. 2007 Jun;132(7):2533-41. doi: 10.1053/j.gastro.2006.12.035. Epub 2006 Dec 20.
16	Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.Gastroenterology. 2014 Mar;146(3):801-11. doi: 10.1053/j.gastro.2013.11.008. Epub 2013 Nov 18.