Details of Disease

General Information of Disease (ID: DISXEPHQ)

• Disease Name: Alcoholic liver diseases
• Synonyms: liver disease, alcoholic; alcoholic liver damage; alcoholic liver disease; alcoholic liver diseases
• Definition: A disorder caused by damage to the liver parenchyma due to alcohol consumption. It may present with an acute onset or follow a chronic course, leading to cirrhosis.
• Disease Hierarchy:
  DIS3SFYT: Alcohol-induced disorders
  DIS2OMMF: Liver disease
  DISXEPHQ: Alcoholic liver diseases
• Disease Identifiers:
  MONDO ID: MONDO_0043693
  MESH ID: D008108
  UMLS CUI: C0023896
  MedGen ID: 9793

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 25 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TM6SF2	TTE1OHM	Limited	Genetic Variation	[1]
ABCB11	TTUXCAF	moderate	Biomarker	[2]
HSD17B13	TTDJYZR	moderate	Biomarker	[3]
ADH1A	TT5AHZ0	Strong	Altered Expression	[4]
CD14	TT6I7DC	Strong	Biomarker	[5]
CXCL1	TTLK1RW	Strong	Biomarker	[6]
CYP2E1	TTWVHQ5	Strong	Biomarker	[7]
DEPTOR	TTLYP6D	Strong	Biomarker	[8]
FFAR4	TT08JVB	Strong	Altered Expression	[9]
HCAR2	TTWNV8U	Strong	Biomarker	[10]
HDAC11	TT8K17W	Strong	Biomarker	[11]
PNPLA3	TTEUAEH	Strong	Genetic Variation	[1]
PPARD	TT2JWF6	Strong	Biomarker	[12]
RBP4	TT0C8BY	Strong	Biomarker	[13]
SPP1	TT8ME6I	Strong	Biomarker	[14]
CAV1	TTXUBN2	Definitive	Therapeutic	[15]
CD27	TTDO1MV	Definitive	Biomarker	[16]
CD59	TTBGTEJ	Definitive	Biomarker	[17]
CXCL2	TTZF0K2	Definitive	Biomarker	[18]
IGF2	TTE8WGO	Definitive	Biomarker	[19]
LPL	TTOF3WZ	Definitive	Therapeutic	[20]
MIF	TT6804T	Definitive	Biomarker	[21]
OTC	TT5KIO9	Definitive	Biomarker	[22]
TBXAS1	TTKNWZ4	Definitive	Biomarker	[23]
UCHL5	TTSX29Z	Definitive	Biomarker	[24]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCD1	DTKM9DZ	Definitive	Biomarker	[25]
SLC39A13	DTOTKBS	Definitive	Biomarker	[26]

This Disease Is Related to 4 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
AKR1A1	DED2FW3	Strong	Genetic Variation	[27]
GPT	DER5HFI	Strong	Biomarker	[28]
GSTA4	DEH7XYP	Strong	Biomarker	[29]
MAT1A	DEQ6NC9	Strong	Altered Expression	[30]

This Disease Is Related to 17 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CERS6	OTOP4GV1	Strong	Biomarker	[31]
CLEC4E	OT7P8ICY	Strong	Biomarker	[32]
DOCK11	OTFSTN6A	Strong	Biomarker	[33]
GOLM1	OTOZSV6O	Strong	Altered Expression	[34]
MBOAT7	OTHRCBLK	Strong	Genetic Variation	[35]
MPRIP	OT5FV5NS	Strong	Biomarker	[36]
MYOM2	OTD2UOXW	Strong	Genetic Variation	[37]
NFE2	OTLM94BI	Strong	Biomarker	[38]
NXN	OT35N40G	Strong	Biomarker	[39]
PIWIL2	OT1PXQIF	Strong	Biomarker	[40]
PSMC5	OTJOORMR	Strong	Biomarker	[38]
REG3G	OTLIUY8Z	Strong	Biomarker	[41]
SF3B3	OTAC9LZT	Strong	Biomarker	[32]
CXCL6	OTFTCQ4O	Definitive	Biomarker	[18]
EIF2S1	OTM0GDTP	Definitive	Biomarker	[42]
NCAN	OT8OO6ZE	Definitive	Genetic Variation	[43]
PSMD14	OTJWHMZ5	Definitive	Biomarker	[24]

References

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• [9] Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease.Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3190-3201. doi: 10.1016/j.bbadis.2017.08.026. Epub 2017 Aug 25.
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• [22] Ornithine carbamyltransferase is a sensitive marker for alcohol-induced liver injury.Clin Chim Acta. 2009 Mar;401(1-2):100-4. doi: 10.1016/j.cca.2008.11.027. Epub 2008 Dec 10.
• [23] Alterations in thromboxane synthase and thromboxane A2 receptors in experimental alcoholic liver disease.J Pharmacol Exp Ther. 1997 Aug;282(2):1037-43.
• [24] Chronic ethanol feeding affects proteasome-interacting proteins.Proteomics. 2009 Jul;9(13):3609-22. doi: 10.1002/pmic.200800959.
• [25] PNPLA3 I148M polymorphism, clinical presentation, and survival in patients with hepatocellular carcinoma.PLoS One. 2013 Oct 14;8(10):e75982. doi: 10.1371/journal.pone.0075982. eCollection 2013.
• [26] Zinc deficiency mediates alcohol-induced apoptotic cell death in the liver of rats through activating ER and mitochondrial cell death pathways.Am J Physiol Gastrointest Liver Physiol. 2015 May 1;308(9):G757-66. doi: 10.1152/ajpgi.00442.2014. Epub 2015 Mar 12.
• [27] ADH1C*2 allele is associated with alcohol dependence and elevated liver enzymes in Trinidad and Tobago.Alcohol. 2006 Jun;39(2):81-6. doi: 10.1016/j.alcohol.2006.08.002.
• [28] Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice.Chin J Nat Med. 2019 Jan;17(1):33-42. doi: 10.1016/S1875-5364(19)30007-X.
• [29] Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet.Alcohol Clin Exp Res. 2018 Jul;42(7):1192-1205. doi: 10.1111/acer.13766. Epub 2018 May 30.
• [30] Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer.Alcohol. 2005 Apr;35(3):227-34. doi: 10.1016/j.alcohol.2005.03.011.
• [31] A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.FASEB J. 2018 Jan;32(1):130-142. doi: 10.1096/fj.201601142R. Epub 2017 Sep 1.
• [32] Spliceosome-Associated Protein 130 Exacerbates Alcohol-Induced Liver Injury by Inducing NLRP3 Inflammasome-Mediated IL-1 in Mice.Am J Pathol. 2018 Apr;188(4):967-980. doi: 10.1016/j.ajpath.2017.12.010. Epub 2018 Jan 31.
• [33] ACG Clinical Guideline: Alcoholic Liver Disease.Am J Gastroenterol. 2018 Feb;113(2):175-194. doi: 10.1038/ajg.2017.469. Epub 2018 Jan 16.
• [34] CXCL10 decreases GP73 expression in hepatoma cells at the early stage of hepatitis C virus (HCV) infection.Int J Mol Sci. 2013 Dec 13;14(12):24230-41. doi: 10.3390/ijms141224230.
• [35] The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth.Am J Gastroenterol. 2018 Mar;113(3):376-383. doi: 10.1038/ajg.2018.1. Epub 2018 Feb 27.
• [36] New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases.World J Gastroenterol. 2014 Sep 28;20(36):12908-33. doi: 10.3748/wjg.v20.i36.12908.
• [37] Effect of PNPLA3 rs738409 variant (I148 M) on hepatic steatosis, necroinflammation, and fibrosis in Japanese patients with chronic hepatitis C.J Gastroenterol. 2015 Aug;50(8):887-93. doi: 10.1007/s00535-014-1018-z. Epub 2014 Nov 26.
• [38] Molecular genetic aspects of alcohol metabolism and alcoholism.Pharmacopsychiatry. 1997 May;30(3):79-84. doi: 10.1055/s-2007-979487.
• [39] Ethanol targets nucleoredoxin/dishevelled interactions and stimulates phosphatidylinositol 4-phosphate production in vivo and in vitro.Biochem Pharmacol. 2018 Oct;156:135-146. doi: 10.1016/j.bcp.2018.08.021. Epub 2018 Aug 18.
• [40] Association between the concurrence of pre-existing chronic liver disease and worse prognosis in patients with an herb- Polygonum multiflorum thunb. induced liver injury: a case-control study from a specialised liver disease center in China.BMJ Open. 2019 Jan 15;9(1):e023567. doi: 10.1136/bmjopen-2018-023567.
• [41] Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice.Gut. 2019 Aug;68(8):1504-1515. doi: 10.1136/gutjnl-2018-317232. Epub 2018 Nov 17.
• [42] [Role of PERK/eIF2a signaling pathway in hepatocyte apoptosis of alcoholic liver injury rats].Zhonghua Gan Zang Bing Za Zhi. 2010 Oct;18(10):768-72. doi: 10.3760/cma.j.issn.1007-3418.2010.10.011.
• [43] A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease.J Hepatol. 2014 Nov;61(5):1073-9. doi: 10.1016/j.jhep.2014.06.006. Epub 2014 Jun 16.