Details of Disease | DrugMAP

General Information of Disease (ID: DISBY98Q)

Disease Name	Breast lobular carcinoma
Synonyms	lobule of mammary gland carcinoma; lobular carcinoma of the breast; lobular carcinoma of breast; lobular carcinoma; lobular breast carcinoma; lobular adenocarcinoma; carcinoma of lobule of mammary gland
Definition	An adenocarcinoma of the breast arising from the lobules. This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal.
Disease Hierarchy	DISMPHJ0: Breast adenocarcinoma DISH9F1N: Carcinoma DISBY98Q: Breast lobular carcinoma
Disease Identifiers	MONDO ID MONDO_0000552 MESH ID D018275 UMLS CUI C0206692 MedGen ID 64634 SNOMED CT ID 278054005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
EGFL7	TT7WD0H	Limited	Altered Expression	[1]
AGTR1	TT8DBY3	moderate	Biomarker	[2]
AGTR2	TTQVOEI	Strong	Biomarker	[2]
CDH1	TTLAWO6	Strong	Genetic Variation	[3]
NKX3-1	TT1E0JK	Strong	Altered Expression	[4]
PYGM	TTZHY6R	Strong	Genetic Variation	[5]
WWP1	TTBWMKT	Strong	Biomarker	[6]
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⏷ Show the Full List of 7 DTT(s)

This Disease Is Related to 12 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AKAP4	OTL4Z99V	Limited	Genetic Variation	[7]
CCL27	OTUZYC61	Strong	Genetic Variation	[8]
CITED4	OTR6NHI2	Strong	Posttranslational Modification	[9]
GABARAP	OTAQUX6E	Strong	Altered Expression	[10]
MIEN1	OTCQ8DAD	Strong	Altered Expression	[11]
MYH9	OT94Z706	Strong	Biomarker	[12]
NFIB	OTX94PD0	Strong	Genetic Variation	[13]
PLEKHA7	OTNUMAZ0	Strong	Altered Expression	[14]
PPP1R12B	OTONIS87	Strong	Biomarker	[12]
STAT5A	OTBSJGN3	Strong	Biomarker	[15]
SULT4A1	OT7AL3KJ	Strong	Genetic Variation	[16]
TP53BP2	OTOWJ2Y4	Strong	Biomarker	[12]
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⏷ Show the Full List of 12 DOT(s)

References

1	Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer.Int J Oncol. 2013 Apr;42(4):1367-75. doi: 10.3892/ijo.2013.1820. Epub 2013 Feb 8.
2	Enhanced expression of angiotensin II receptor subtypes and angiotensin converting enzyme in medroxyprogesterone-induced mouse mammary adenocarcinomas.Biochem Biophys Res Commun. 1993 May 28;193(1):93-9. doi: 10.1006/bbrc.1993.1594.
3	Synchronous appendiceal and intramucosal gastric signet ring cell carcinomas in an individual with CDH1-associated hereditary diffuse gastric carcinoma: a case report of a novel association and review of the literature.BMC Gastroenterol. 2013 Jul 12;13:114. doi: 10.1186/1471-230X-13-114.
4	Expression of NKX3.1 in normal and malignant tissues.Prostate. 2003 May 1;55(2):111-7. doi: 10.1002/pros.10210.
5	Whole exome sequencing of rare aggressive breast cancer histologies.Breast Cancer Res Treat. 2016 Feb;156(1):21-32. doi: 10.1007/s10549-016-3718-y. Epub 2016 Feb 23.
6	Overexpression of WWP1 is associated with the estrogen receptor and insulin-like growth factor receptor 1 in breast carcinoma.Int J Cancer. 2009 Jun 15;124(12):2829-36. doi: 10.1002/ijc.24266.
7	A novel cancer testis antigen, A-kinase anchor protein 4 (AKAP4) is a potential biomarker for breast cancer.PLoS One. 2013;8(2):e57095. doi: 10.1371/journal.pone.0057095. Epub 2013 Feb 22.
8	Tumor microenvironment in invasive lobular carcinoma: possible therapeutic targets.Breast Cancer Res Treat. 2016 Jan;155(1):65-75. doi: 10.1007/s10549-015-3668-9. Epub 2015 Dec 29.
9	Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.Breast Cancer Res Treat. 2011 Nov;130(1):319-29. doi: 10.1007/s10549-011-1657-1. Epub 2011 Jul 14.
10	Characterization of {gamma}-aminobutyric acid type A receptor-associated protein, a novel tumor suppressor, showing reduced expression in breast cancer.Cancer Res. 2005 Jan 15;65(2):394-400.
11	C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer.Mol Cancer Ther. 2006 Nov;5(11):2919-30. doi: 10.1158/1535-7163.MCT-06-0389.
12	Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma.Nat Genet. 2017 Aug;49(8):1219-1230. doi: 10.1038/ng.3905. Epub 2017 Jun 26.
13	Histological types of breast cancer: how special are they?.Mol Oncol. 2010 Jun;4(3):192-208. doi: 10.1016/j.molonc.2010.04.004. Epub 2010 Apr 18.
14	Genetic up-regulation and overexpression of PLEKHA7 differentiates invasive lobular carcinomas from invasive ductal carcinomas.Hum Pathol. 2012 Nov;43(11):1902-9. doi: 10.1016/j.humpath.2012.01.017. Epub 2012 Apr 25.
15	Possible role of Stat5a in rat mammary gland carcinogenesis.Breast Cancer Res Treat. 2004 Dec;88(3):263-72. doi: 10.1007/s10549-004-0805-2.
16	Transcriptomic analysis of tubular carcinomas of the breast reveals similarities and differences with molecular subtype-matched ductal and lobular carcinomas.J Pathol. 2010 Sep;222(1):64-75. doi: 10.1002/path.2743.