Details of Disease

Disease Name

Breast adenocarcinoma

mammary adenocarcinoma; breast adenocarcinoma; adenocarcinoma of breast; adenocarcinoma of the breast

Definition

A carcinoma that arises from glandular epithelial cells of the breast

Disease Hierarchy

DISZQRYL: Integumentary system cancer

DIS3IHTY: Adenocarcinoma

DIS2UE88: Breast carcinoma

DISMPHJ0: Breast adenocarcinoma

Disease Identifiers

MONDO ID

MONDO_0004988

UMLS CUI

C0858252

MedGen ID

167809

SNOMED CT ID

865954003

General Information of Disease (ID: DISMPHJ0)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 15 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
EPCAM	TTZ8WH4	Limited	Biomarker	[1]
PGRMC1	TTY3LAZ	Limited	Biomarker	[2]
TRPV6	TTBK14N	Limited	Biomarker	[3]
EPHA3	TTHS2LR	moderate	Biomarker	[4]
GATA3	TT45KOB	moderate	Biomarker	[5]
HRAS	TT28ZON	moderate	Altered Expression	[6]
PLP2	TTK5OG6	moderate	Biomarker	[7]
AKR1B1	TTFBNVI	Strong	Biomarker	[8]
CYP1B1	TTI84H7	Strong	Biomarker	[9]
EPHB6	TTZEMUY	Strong	Altered Expression	[10]
FDXR	TT3W4IX	Strong	Biomarker	[8]
FMNL1	TTW20PQ	Strong	Biomarker	[11]
PIK3CA	TTEUNMR	Strong	Altered Expression	[12]
RPS6KA6	TT3KYWB	Strong	Altered Expression	[13]
TBL1X	TTAL6S1	Strong	Altered Expression	[14]
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⏷ Show the Full List of 15 DTT(s)

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC20A1	DTMULXV	moderate	Altered Expression	[15]
SLC2A13	DT0NSKB	Strong	Altered Expression	[16]
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This Disease Is Related to 32 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCN5	OTADU8JJ	Limited	Altered Expression	[17]
CCT4	OT5D452X	Limited	Genetic Variation	[18]
PGRMC2	OTH6G1CV	Limited	Biomarker	[2]
POU1F1	OTXT8A5C	moderate	Altered Expression	[15]
ACSBG1	OTM040MW	Strong	Biomarker	[19]
ALDH3A1	OTAYZZE6	Strong	Altered Expression	[20]
ANKRD1	OTHJ7JV9	Strong	Altered Expression	[10]
BRCA1	OT5BN6VH	Strong	Biomarker	[21]
BTC	OTW4B2O0	Strong	Altered Expression	[22]
CA8	OT9Y8GA8	Strong	Altered Expression	[10]
CANX	OTYP1F6J	Strong	Altered Expression	[23]
CSRP1	OTUS7RM2	Strong	Biomarker	[24]
DNLZ	OT48CG1W	Strong	Altered Expression	[10]
FNBP1L	OTH1S2P2	Strong	Biomarker	[25]
GABARAPL1	OT4U7SBG	Strong	Biomarker	[26]
IBSP	OT29944Y	Strong	Biomarker	[27]
IPO9	OT1DGLQE	Strong	Altered Expression	[28]
IRF9	OTK4MYQJ	Strong	Altered Expression	[29]
KCNH4	OTHJ8WTU	Strong	Altered Expression	[30]
KCNH8	OT3I5FLB	Strong	Altered Expression	[30]
KDM8	OTCN5ST8	Strong	Altered Expression	[31]
LYNX1	OTK4103B	Strong	Biomarker	[32]
MINDY3	OT6YZPWC	Strong	Altered Expression	[10]
MXI1	OTUQ9E0D	Strong	Biomarker	[33]
NONO	OTN36Q6U	Strong	Biomarker	[34]
NUDT18	OT03IQA5	Strong	Biomarker	[35]
PAF1	OTDDGUBQ	Strong	Biomarker	[36]
PDLIM4	OT23LZYY	Strong	Biomarker	[24]
RAPH1	OTMQXW7S	Strong	Biomarker	[19]
SEMA6B	OT3VVVUO	Strong	Altered Expression	[37]
TBL1Y	OTA0F7TM	Strong	Altered Expression	[14]
TNFSF18	OT3ANRX1	Strong	Biomarker	[38]
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⏷ Show the Full List of 32 DOT(s)

References

1	Multifunctional Hybrid Magnetic Microgel Synthesis for Immune-Based Isolation and Post-Isolation Culture of Tumor Cells.ACS Appl Mater Interfaces. 2019 Jul 17;11(28):24945-24958. doi: 10.1021/acsami.9b02959. Epub 2019 Jul 3.
2	Transcriptional analysis of novel hormone receptors PGRMC1 and PGRMC2 as potential biomarkers of breast adenocarcinoma staging.J Surg Res. 2011 Dec;171(2):615-22. doi: 10.1016/j.jss.2010.04.034. Epub 2010 May 20.
3	The role of TRPV6 in breast carcinogenesis.Mol Cancer Ther. 2008 Feb;7(2):271-9. doi: 10.1158/1535-7163.MCT-07-0478. Epub 2008 Feb 1.
4	Green synthesis of highly fluorescent nitrogen - Doped carbon dots from Lantana camara berries for effective detection of lead(II) and bioimaging.J Photochem Photobiol B. 2018 Jan;178:330-338. doi: 10.1016/j.jphotobiol.2017.11.010. Epub 2018 Jan 4.
5	Utility of GATA-3 in the work-Up of breast adenocarcinoma and its differential diagnosis in serous effusions:: A Cell-Block Microarray Study.Diagn Cytopathol. 2016 Sep;44(9):731-6. doi: 10.1002/dc.23521. Epub 2016 Jun 24.
6	Suppression of the proliferation and migration of oncogenic ras-dependent cell lines, cultured in a three-dimensional collagen matrix, by flavonoid-structured molecules.J Cancer Res Clin Oncol. 1996;122(6):335-42. doi: 10.1007/BF01220800.
7	Flavonoid Composition and Antitumor Activity of Bee Bread Collected in Northeast Portugal.Molecules. 2017 Feb 7;22(2):248. doi: 10.3390/molecules22020248.
8	Pyramidatine (Z88) Sensitizes Vincristine-Resistant Human Oral Cancer (KB/VCR) Cells to Chemotherapeutic Agents by Inhibition of P-glycoprotein.Anticancer Agents Med Chem. 2018;18(2):286-294. doi: 10.2174/1871520617666170803155025.
9	Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis.Breast Cancer Res Treat. 2000 Sep;63(2):117-31. doi: 10.1023/a:1006443104670.
10	In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene on 17beta-estradiol-induced gene expression in several bioassay systems.Toxicol Sci. 2002 Oct;69(2):362-72. doi: 10.1093/toxsci/69.2.362.
11	The carboxy-terminus of the formin FMNL1 bundles actin to potentiate adenocarcinoma migration.J Cell Biochem. 2019 Sep;120(9):14383-14404. doi: 10.1002/jcb.28694. Epub 2019 Apr 11.
12	Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents.Med Chem. 2018;14(7):695-708. doi: 10.2174/1573406414666180412160142.
13	RSK4 knockdown promotes proliferation, migration and metastasis of human breast adenocarcinoma cells.Oncol Rep. 2015 Dec;34(6):3156-62. doi: 10.3892/or.2015.4291. Epub 2015 Sep 18.
14	Transducin -like protein 1 recruits nuclear factor B to the target gene promoter for transcriptional activation.Mol Cell Biol. 2011 Mar;31(5):924-34. doi: 10.1128/MCB.00576-10. Epub 2010 Dec 28.
15	Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13.Breast Cancer Res. 2014 Dec 20;16(6):505. doi: 10.1186/s13058-014-0505-8.
16	H?myo-inositol transporter SLC2A13 as a potential marker for cancer stem cells in an oral squamous cell carcinoma.Curr Cancer Drug Targets. 2011 Oct;11(8):966-75. doi: 10.2174/156800911797264752.
17	CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells.Cancer Res. 2008 Sep 15;68(18):7606-12. doi: 10.1158/0008-5472.CAN-08-1461.
18	Pyrrolizines as Potential Anticancer Agents: Design, Synthesis, Caspase-3 activation and Micronucleus (MN) Induction.Anticancer Agents Med Chem. 2018;18(15):2124-2130. doi: 10.2174/1871520618666180409155520.
19	In vivo efficacy of folate-targeted lipid-protamine-DNA (LPD-PEG-Folate) complexes in an immunocompetent syngeneic model for breast adenocarcinoma.Cancer Gene Ther. 2004 Feb;11(2):128-34. doi: 10.1038/sj.cgt.7700662.
20	Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes.Chem Biol Interact. 2001 Jan 30;130-132(1-3):247-60. doi: 10.1016/s0009-2797(00)00269-6.
21	Multicentric glioblastoma multiforme in a patient with BRCA-1 invasive breast cancer.Breast J. 2006 Sep-Oct;12(5):470-4. doi: 10.1111/j.1075-122X.2006.00307.x.
22	Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding.J Cell Biochem. 2006 Oct 1;99(2):609-23. doi: 10.1002/jcb.20968.
23	The expression of the molecular chaperone calnexin is decreased in cancer cells grown as colonies compared to monolayer.Biochem Biophys Res Commun. 1997 Sep 8;238(1):66-70. doi: 10.1006/bbrc.1997.7238.
24	The LIM domain protein FHL1C interacts with tight junction protein ZO-1 contributing to the epithelial-mesenchymal transition (EMT) of a breast adenocarcinoma cell line.Gene. 2014 Jun 1;542(2):182-9. doi: 10.1016/j.gene.2014.03.036. Epub 2014 Mar 19.
25	Transducer of Cdc42-dependent actin assembly promotes breast cancer invasion and metastasis.Oncogene. 2013 Jun 20;32(25):3080-90. doi: 10.1038/onc.2012.317. Epub 2012 Jul 23.
26	High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer.Br J Cancer. 2010 Mar 16;102(6):1024-31. doi: 10.1038/sj.bjc.6605568. Epub 2010 Mar 2.
27	Radioiodination and preclinical evaluation of 4-benzyl-1-(3-[(125)I]-iodobenzylsulfonyl)piperidine as a breast tumor imaging tracer in mouse.Ann Nucl Med. 2017 May;31(4):335-346. doi: 10.1007/s12149-017-1161-8. Epub 2017 Mar 17.
28	Downregulation of importin-9 protects MCF-7 cells against apoptosis induced by the combination of garlic-derived alliin and paclitaxel.Oncol Rep. 2016 May;35(5):3084-93. doi: 10.3892/or.2016.4628. Epub 2016 Feb 22.
29	Overexpression of IRF9 confers resistance to antimicrotubule agents in breast cancer cells.Cancer Res. 2001 Sep 1;61(17):6540-7.
30	Epidermal growth factor regulates PAI-1 expression via activation of the transcription factor Elk-1.Biochim Biophys Acta. 2010 Sep;1799(9):616-21. doi: 10.1016/j.bbagrm.2010.08.004. Epub 2010 Aug 19.
31	Overexpression of histone demethylase JMJD5 promotes metastasis and indicates a poor prognosis in breast cancer.Int J Clin Exp Pathol. 2015 Sep 1;8(9):10325-34. eCollection 2015.
32	Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of 7 nicotinic acetylcholine receptors.PLoS One. 2019 May 31;14(5):e0217339. doi: 10.1371/journal.pone.0217339. eCollection 2019.
33	Mxi1 is a potential cellular target of carcinogens and frequently mutated in experimental rat tumors and tumor cell lines.Pathol Int. 2000 May;50(5):373-83. doi: 10.1046/j.1440-1827.2000.01057.x.
34	Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen receptor-negative human breast cancer.Diagn Mol Pathol. 1997 Aug;6(4):209-21. doi: 10.1097/00019606-199708000-00005.
35	Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study.Int J Oncol. 2018 Jan;52(1):67-76. doi: 10.3892/ijo.2017.4204. Epub 2017 Nov 14.
36	New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies.J Photochem Photobiol B. 2018 Jan;178:428-439. doi: 10.1016/j.jphotobiol.2017.11.030. Epub 2017 Nov 22.
37	Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells. Int J Oncol. 2006 Apr;28(4):977-84.
38	Efficacy of cytokine-induced killer cells targeting CD40 and GITR.Oncol Lett. 2019 Feb;17(2):2425-2430. doi: 10.3892/ol.2018.9849. Epub 2018 Dec 18.