Details of Disease

General Information of Disease (ID: DISCAVOZ)

Disease Name	Disseminated intravascular coagulation
Synonyms	intravascular coagulation (DIC), disseminated; disseminated intravascular coagulation (DIC); disseminated intravascular coagulation; diffuse or disseminated intravascular coagulation; defibrination syndrome; consumptive coagulopathy; coagulation (DIC), disseminated intravascular; DIC, disseminated intravascular coagulation; DIC
Disease Class	3B20: Disseminated intravascular coagulation
Definition	A pathological process where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage.
Disease Hierarchy	DISQR7U7: Thrombophilia DISCAVOZ: Disseminated intravascular coagulation
ICD Code	ICD-11 ICD-11: 3B20 ICD-10 ICD-10: D65 ICD-9 ICD-9: 286.6 Expand ICD-11 '3B20 Expand ICD-10 'D65 Expand ICD-9 286.6
Disease Identifiers	MONDO ID MONDO_0001243 MESH ID D004211 UMLS CUI C0012739 MedGen ID 41620 HPO ID HP:0005521 SNOMED CT ID 67406007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Drugs in Phase 2 Trial

Drug Name	Drug ID	Highest Status	Drug Type	REF
Heparin	DM4ZP3W	Phase 2/3 Trial	Small molecular drug	[1]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Thrombomodulin	DMWNXES	Discontinued in Phase 3	NA	[2]
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This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ART-123	DMS2E0J	Preclinical	NA	[3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 13 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
F10	TTCIHJA	Limited	Genetic Variation	[4]
PLD1	TT3T17P	moderate	Biomarker	[5]
SERPINE1	TTTO43N	moderate	Biomarker	[6]
ADAMTS13	TTUREBK	Strong	Altered Expression	[7]
F13A1	TTXI2RA	Strong	Biomarker	[8]
F7	TTF0EGX	Strong	Biomarker	[9]
PLAT	TTXAGYU	Strong	Biomarker	[6]
PROC	TTZUXYS	Strong	Biomarker	[10]
RNF34	TTEWDK1	Strong	Biomarker	[11]
SERPINC1	TT4QPUL	Strong	Biomarker	[12]
SERPIND1	TT8XSKJ	Strong	Biomarker	[13]
TFPI	TT068JH	Strong	Biomarker	[14]
THBD	TTAPV67	Definitive	Biomarker	[15]
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⏷ Show the Full List of 13 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A10	DTJYKDQ	Strong	Biomarker	[16]
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This Disease Is Related to 17 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FCRL6	OTLIXQMQ	Limited	Biomarker	[17]
FGA	OTMIHY80	Limited	Biomarker	[18]
PRH1	OTQZ6HX0	Limited	Altered Expression	[19]
STIL	OT9799VN	Limited	Biomarker	[20]
CEACAM8	OTLL9WWO	moderate	Biomarker	[21]
CLDN10	OT2CVAKY	moderate	Biomarker	[22]
DNAI2	OTHK0PS4	moderate	Biomarker	[23]
IL4I1	OTK54C63	moderate	Genetic Variation	[24]
MASP1	OTWWCNZP	moderate	Biomarker	[25]
BTBD8	OT3A3RD7	Strong	Genetic Variation	[26]
COLEC11	OT4GC46Y	Strong	Altered Expression	[27]
OTOR	OTA62UQB	Strong	Altered Expression	[28]
OXT	OT48M72Z	Strong	Biomarker	[29]
PC	OT6O0V51	Strong	Biomarker	[30]
PROS1	OTXQWNOI	Strong	Biomarker	[31]
RHOF	OTPA3F8Q	Strong	Biomarker	[11]
SH3BP4	OTVIRKW7	Strong	Biomarker	[32]
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⏷ Show the Full List of 17 DOT(s)

References

1	Heparin FDA Label
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002139)
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028974)
4	Fondaparinux cross-reactivity in heparin-induced thrombocytopenia successfully treated with high-dose intravenous immunoglobulin and rivaroxaban.Platelets. 2020;31(1):124-127. doi: 10.1080/09537104.2019.1652263. Epub 2019 Aug 9.
5	Phospholipase D1 regulation of TNF-alpha protects against responses to LPS.Sci Rep. 2018 Jul 3;8(1):10006. doi: 10.1038/s41598-018-28331-y.
6	Disseminated intravascular coagulation in cardiac arrest and resuscitation.J Thromb Haemost. 2019 Aug;17(8):1205-1216. doi: 10.1111/jth.14480. Epub 2019 Jun 5.
7	Von Willebrand factor and ADAMTS13 impact on the outcome of Staphylococcus aureus sepsis.J Thromb Haemost. 2020 Mar;18(3):722-731. doi: 10.1111/jth.14686. Epub 2019 Dec 22.
8	Plasma factor XIII activity in patients with disseminated intravascular coagulation.Yonsei Med J. 2006 Apr 30;47(2):196-200. doi: 10.3349/ymj.2006.47.2.196.
9	Use of recombinant factor VIIa in patients with warfarin-associated intracranial hemorrhage.Neurocrit Care. 2005;2(3):263-7. doi: 10.1385/NCC:2:3:263.
10	Endothelial Dysfunction Is Associated with Mortality and Severity of Coagulopathy in Patients with Sepsis and Disseminated Intravascular Coagulation.Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619852163. doi: 10.1177/1076029619852163.
11	The impact of oral arsenic and all-trans-retinoic acid on coagulopathy in acute promyelocytic leukemia.Leuk Res. 2018 Feb;65:14-19. doi: 10.1016/j.leukres.2017.11.009. Epub 2017 Nov 15.
12	Anticoagulation Therapy Using rh-Thrombomodulin and/or Antithrombin III Agent is Associated With Reduction in in-Hospital Mortality in Septic Disseminated Intravascular Coagulation: A Nationwide Registry Study.Shock. 2019 Jun;51(6):713-717. doi: 10.1097/SHK.0000000000001230.
13	Prothrombin G20210A gene mutation, heparin cofactor II defects, primary (essential) thrombocythemia, and thrombohemorrhagic manifestations.Semin Thromb Hemost. 1999;25(4):375-86. doi: 10.1055/s-2007-994941.
14	Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies.Clin Appl Thromb Hemost. 2018 Dec;24(9_suppl):8S-28S. doi: 10.1177/1076029618806424. Epub 2018 Oct 8.
15	Multicenter clinical experience with recombinant soluble thrombomodulin for disseminated intravascular coagulation associated with severe acute cholecystitis.Thromb Res. 2019 Apr;176:74-78. doi: 10.1016/j.thromres.2018.12.025. Epub 2019 Feb 13.
16	New onset acute promyelocytic Leukemia during pregnancy: report of 2 cases.Cancer Biol Ther. 2019;20(4):397-401. doi: 10.1080/15384047.2018.1529122. Epub 2018 Nov 19.
17	Differential expression of leukocyte receptors in disseminated intravascular coagulation: prognostic value of low protein C receptor expression.Thromb Res. 2014 Nov;134(5):1130-4. doi: 10.1016/j.thromres.2014.08.026. Epub 2014 Sep 6.
18	Down-regulated expression of AQP5 on lung in rat DIC model induced by LPS and its effect on the development of pulmonary edema.Pulm Pharmacol Ther. 2013 Dec;26(6):661-5. doi: 10.1016/j.pupt.2013.03.013. Epub 2013 Mar 26.
19	A novel fibrinogenase from Agkistrodon acutus venom protects against DIC via direct degradation of thrombosis and activation of protein C.Biochem Pharmacol. 2012 Oct 1;84(7):905-13. doi: 10.1016/j.bcp.2012.06.011. Epub 2012 Jun 20.
20	SIL-TAL1 rearrangement is related with poor outcome: a study from a Chinese institution.PLoS One. 2013 Sep 9;8(9):e73865. doi: 10.1371/journal.pone.0073865. eCollection 2013.
21	Evidence of Netosis in Septic Shock-Induced Disseminated Intravascular Coagulation.Shock. 2017 Mar;47(3):313-317. doi: 10.1097/SHK.0000000000000719.
22	Therapeutic hypothermia for moderate and severe hypoxic ischaemic encephalopathy in newborns using low-cost devices - ice packs and phase changing material.Paediatr Int Child Health. 2019 Nov;39(4):234-239. doi: 10.1080/20469047.2018.1500805. Epub 2018 Aug 15.
23	Activation of the coagulation cascade in patients with scrub typhus.Diagn Microbiol Infect Dis. 2017 Sep;89(1):1-6. doi: 10.1016/j.diagmicrobio.2017.06.011. Epub 2017 Jun 19.
24	Comparative proteomes, immunoreactivities and neutralization of procoagulant activities of Calloselasma rhodostoma (Malayan pit viper) venoms from four regions in Southeast Asia.Toxicon. 2019 Nov;169:91-102. doi: 10.1016/j.toxicon.2019.08.004. Epub 2019 Aug 22.
25	Reduced Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 is Associated with Disturbed Coagulation in Septic Shock.Thromb Haemost. 2019 Jun;119(6):952-961. doi: 10.1055/s-0039-1685140. Epub 2019 Apr 15.
26	A multicenter, prospective evaluation of the Chinese Society of Thrombosis and Hemostasis Scoring System for disseminated intravascular coagulation.Thromb Res. 2019 Jan;173:131-140. doi: 10.1016/j.thromres.2018.11.022. Epub 2018 Nov 23.
27	Changes in Mannose-Binding Lectin and Collectin Kidney 1 Levels in Sepsis Patients With and Without Disseminated Intravascular Coagulation.Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029618821189. doi: 10.1177/1076029618821189.
28	Role of Vascular Endothelial Cells in Disseminated Intravascular Coagulation Induced by Seawater Immersion in a Rat Trauma Model.Biomed Res Int. 2017;2017:5147532. doi: 10.1155/2017/5147532. Epub 2017 Jun 28.
29	Labor induction with dinoprostone or oxytocine and postpartum disseminated intravascular coagulation: a hospital-based case-control study.Am J Obstet Gynecol. 2004 Nov;191(5):1637-43. doi: 10.1016/j.ajog.2004.03.021.
30	Biomarkers of disseminated intravascular coagulation in pediatric intensive care unit in Thailand.Int J Lab Hematol. 2019 Feb;41(1):32-38. doi: 10.1111/ijlh.12917. Epub 2018 Sep 12.
31	Skin Necrosis and Purpura Fulminans in Children With and Without Thrombophilia--A Tertiary Center's Experience.Pediatr Hematol Oncol. 2015;32(7):505-10. doi: 10.3109/08880018.2015.1068896. Epub 2015 Oct 5.
32	Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury.Crit Care Clin. 2015 Oct;31(4):661-74. doi: 10.1016/j.ccc.2015.06.004. Epub 2015 Aug 7.